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Volume 20 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2002  >  (2): 84-86

SHANG Bei-cheng, XU Gui-li, TANG Bing, FANG Li-sha, LIU Jiang, DUAN Hui-qiong, ZHAO Xing-min. The enhancement effect of dipentene in the transdermal absorption of ketoconazole[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 84-86.
Citation: SHANG Bei-cheng, XU Gui-li, TANG Bing, FANG Li-sha, LIU Jiang, DUAN Hui-qiong, ZHAO Xing-min. The enhancement effect of dipentene in the transdermal absorption of ketoconazole[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 84-86.
shu

The enhancement effect of dipentene in the transdermal absorption of ketoconazole

  • 1.

    Kunming General Hospital of Chengdu Military Region, Kunming 650032, China

  • 2.

  • 3.

  • Received Date: 2001-05-14
  • OBJECTIVE To study the enhancing effect of dipentene in the transdermal absorption of ketoconazol. METHODS The diffusion of ketoconazole acrossed excised mouse skin was determined in vitro using the side-by-side diffusion cells,to compare the enhancement effect of dipentene with azone at difference concentrations in the transdermal absorption of ketoconazole.RESULTS The sequence of enhancements at difference concentrations of dipentene are as follows:3%dipentene> 2%dipentene> 3%azone> 1%dipentene.CONCLUSION It was showed that various concentrations of transdermal enhancers could promote absorption of ketoconazole in different degrees and 3% dipentene was the most effective.
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通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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The enhancement effect of dipentene in the transdermal absorption of ketoconazole

  • 1. Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
  • 2. 
  • 3. 
  • Received Date: 2001-05-14

Abstract: OBJECTIVE To study the enhancing effect of dipentene in the transdermal absorption of ketoconazol. METHODS The diffusion of ketoconazole acrossed excised mouse skin was determined in vitro using the side-by-side diffusion cells,to compare the enhancement effect of dipentene with azone at difference concentrations in the transdermal absorption of ketoconazole.RESULTS The sequence of enhancements at difference concentrations of dipentene are as follows:3%dipentene> 2%dipentene> 3%azone> 1%dipentene.CONCLUSION It was showed that various concentrations of transdermal enhancers could promote absorption of ketoconazole in different degrees and 3% dipentene was the most effective.

SHANG Bei-cheng, XU Gui-li, TANG Bing, FANG Li-sha, LIU Jiang, DUAN Hui-qiong, ZHAO Xing-min. The enhancement effect of dipentene in the transdermal absorption of ketoconazole[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 84-86.
Citation: SHANG Bei-cheng, XU Gui-li, TANG Bing, FANG Li-sha, LIU Jiang, DUAN Hui-qiong, ZHAO Xing-min. The enhancement effect of dipentene in the transdermal absorption of ketoconazole[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 84-86.
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