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Volume 19 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2001  >  (3): 157-159

WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
Citation: WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
shu

Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat

  • 1.

    Shanghai TCM University, Shanghai 200032, China

  • 2.

  • 3.

  • Received Date: 2000-12-23
  • OBJECTIVE To investigate the protective mechanism of YOL on ischemia/reperfusion (I/R) myocardium.METHODS48 male SD rats,weighting (260±30)g,were divided into 6 groups.They were normal control,I/R,classical ischemic precondition(C-IPC),sham-operated,Isosorbide dinitrate and YOL.The intracelular calcium concentration of the cardiomyocyte and hemodynamic changes were measured in all groups.RESULTS LVSP、±dp/dt in C-IPC and YOL tread with ischemia 30 min and followed by reperfusion 60 min were obviously higher in I/R(P<0.05)while LVSP、±dp/dt of C-IPC was alsodefinitely high compared with YOL(P<0.05).The intracel ular calcium concentrat ion in C-IPC and YOL were lower in I/R(P<0.05),while[Ca2+]I of YOL was increased in C-IPC (P<0.05).CONCLUSIONS Yix in oral Liquid(YOL)precondit ioning can protect the myocardium from I/R.The possible protective mechanism may be due to decrease calcium overload in cardiomyocyte.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat

  • 1. Shanghai TCM University, Shanghai 200032, China
  • 2. 
  • 3. 
  • Received Date: 2000-12-23

Abstract: OBJECTIVE To investigate the protective mechanism of YOL on ischemia/reperfusion (I/R) myocardium.METHODS48 male SD rats,weighting (260±30)g,were divided into 6 groups.They were normal control,I/R,classical ischemic precondition(C-IPC),sham-operated,Isosorbide dinitrate and YOL.The intracelular calcium concentration of the cardiomyocyte and hemodynamic changes were measured in all groups.RESULTS LVSP、±dp/dt in C-IPC and YOL tread with ischemia 30 min and followed by reperfusion 60 min were obviously higher in I/R(P<0.05)while LVSP、±dp/dt of C-IPC was alsodefinitely high compared with YOL(P<0.05).The intracel ular calcium concentrat ion in C-IPC and YOL were lower in I/R(P<0.05),while[Ca2+]I of YOL was increased in C-IPC (P<0.05).CONCLUSIONS Yix in oral Liquid(YOL)precondit ioning can protect the myocardium from I/R.The possible protective mechanism may be due to decrease calcium overload in cardiomyocyte.

WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
Citation: WEI Hong-chang, WANG Xiu-wei, LU Rong, SHENG Jin-bo, ZHU Xiao-mei, WU Qian, ZHANG Chen. Pharmacological preconditioning of Yixin Oral Liquid (YOL) during myocardium ischemia and reperfusion in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 157-159.
shu

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