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Volume 18 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2000  >  (5): 331-333

CHEN Qin, WEI Peijiu, GU Peikun, JIN ZhenjunZhou, ZHONG Yuan. Effects of Guan-fu base A on neonatal rat myocytes in cultures with oxygen and glucose deprivation[J]. Journal of Pharmaceutical Practice and Service, 2000, (5): 331-333.
Citation: CHEN Qin, WEI Peijiu, GU Peikun, JIN ZhenjunZhou, ZHONG Yuan. Effects of Guan-fu base A on neonatal rat myocytes in cultures with oxygen and glucose deprivation[J]. Journal of Pharmaceutical Practice and Service, 2000, (5): 331-333.
shu

Effects of Guan-fu base A on neonatal rat myocytes in cultures with oxygen and glucose deprivation

  • Received Date: 2000-08-28
  • OBJECTIVE To investigate the effects of GFA on neonatal rat myocytes in cultures with oxygen and glucose deprivation(CMOGD).METHODS By taking cultured neonatal rat myocytes with oxygen and glucose deprivation as ischemia-mimic condition of body and the Ca2+-antagonist Verapamil as control,the leakage of lactic dehydrogenase(LDH) and the production of malondialdehyde(MDA) were investigated. RESULT GFA 30ug/ml suppessed the lactic dehydrogenase (LDH) leakage and the production of malondialdehyde (MDA) in CMOGD (P<0.05). The effects on LDH and MDA were concentration-dependant. During the experiment GFA was compared with Verapamil, the traditional Ca--antagonist. It was found the GFA had similar function with Verapamil. CONCLUSION GFA has a cytoprotection on CMOGD,Possibaly acts as an antiperoxidant and/or inhibiter of Ca2+ influx.
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Effects of Guan-fu base A on neonatal rat myocytes in cultures with oxygen and glucose deprivation

  • Received Date: 2000-08-28

Abstract: OBJECTIVE To investigate the effects of GFA on neonatal rat myocytes in cultures with oxygen and glucose deprivation(CMOGD).METHODS By taking cultured neonatal rat myocytes with oxygen and glucose deprivation as ischemia-mimic condition of body and the Ca2+-antagonist Verapamil as control,the leakage of lactic dehydrogenase(LDH) and the production of malondialdehyde(MDA) were investigated. RESULT GFA 30ug/ml suppessed the lactic dehydrogenase (LDH) leakage and the production of malondialdehyde (MDA) in CMOGD (P<0.05). The effects on LDH and MDA were concentration-dependant. During the experiment GFA was compared with Verapamil, the traditional Ca--antagonist. It was found the GFA had similar function with Verapamil. CONCLUSION GFA has a cytoprotection on CMOGD,Possibaly acts as an antiperoxidant and/or inhibiter of Ca2+ influx.

CHEN Qin, WEI Peijiu, GU Peikun, JIN ZhenjunZhou, ZHONG Yuan. Effects of Guan-fu base A on neonatal rat myocytes in cultures with oxygen and glucose deprivation[J]. Journal of Pharmaceutical Practice and Service, 2000, (5): 331-333.
Citation: CHEN Qin, WEI Peijiu, GU Peikun, JIN ZhenjunZhou, ZHONG Yuan. Effects of Guan-fu base A on neonatal rat myocytes in cultures with oxygen and glucose deprivation[J]. Journal of Pharmaceutical Practice and Service, 2000, (5): 331-333.
shu

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