Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 18 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2000  >  (3): 154-156

DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
Citation: DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
shu

Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry

  • Received Date: 1999-11-25
  • OBJECTIVE To provide a useful way of quality control,a first order derivative spectrophotometric method had been developed to determine the content and uniformity of content of fenfuramine hydrochloride tables.METHODS Water was selected for solvent.The first derivative spectrum was obtained by scanning from 280 to 220nm.The distance D of the derivative peak at 265nm and valley at 295nm was used as quantitative basis.The assay was calculated by comparing the peak-valley distance of sample with standard.RESULTS There was a good linear relationship between fenfuramine hydrochloride concentration in the range of 0.05～0.40mg/ml and the peak-valley distance of derivative spectrum with r=0.9999.The average recovery form sample was 100.6%. RSD=0.7%(n=6).CONCLUSIONS The proposed method is simple,accurate and reproducible.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2089) PDF downloads(1129) Cited by()

Related
Proportional views

Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry

  • Received Date: 1999-11-25

Abstract: OBJECTIVE To provide a useful way of quality control,a first order derivative spectrophotometric method had been developed to determine the content and uniformity of content of fenfuramine hydrochloride tables.METHODS Water was selected for solvent.The first derivative spectrum was obtained by scanning from 280 to 220nm.The distance D of the derivative peak at 265nm and valley at 295nm was used as quantitative basis.The assay was calculated by comparing the peak-valley distance of sample with standard.RESULTS There was a good linear relationship between fenfuramine hydrochloride concentration in the range of 0.05～0.40mg/ml and the peak-valley distance of derivative spectrum with r=0.9999.The average recovery form sample was 100.6%. RSD=0.7%(n=6).CONCLUSIONS The proposed method is simple,accurate and reproducible.

DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
Citation: DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return