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Volume 16 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1998  >  (6): 322-325

Liu Yuansheng, Sun Huikuan, Qiu Nengyong, Zhang Yanping. The protective effect of indapndde and verapamil in myocardial ischemia and reperfusion injury in rabbit Langendorff heart[J]. Journal of Pharmaceutical Practice and Service, 1998, (6): 322-325.
Citation: Liu Yuansheng, Sun Huikuan, Qiu Nengyong, Zhang Yanping. The protective effect of indapndde and verapamil in myocardial ischemia and reperfusion injury in rabbit Langendorff heart[J]. Journal of Pharmaceutical Practice and Service, 1998, (6): 322-325.
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The protective effect of indapndde and verapamil in myocardial ischemia and reperfusion injury in rabbit Langendorff heart

  • Department of Cardiovascular Medicine, First Affiliated Hospital, Inner Mongolia Medical College, Huhhot 010050

  • The animal medels of isolated myochoial pehschemic reperfusion injury in rabbits using Langendorff apparatus were used to inquire into the protective effect of indapamide and verapamil. Methods: Twenty - one male rabbits were randomly divided into three groups (n=7 in each): control group, verapamil group and indapamide group. Isolated heaxts were reperfused after 40 min of global no - flow ischemia, Reperfusion oulflow fluid were collected at 15 min,30 min 60 min and 300 min after postischemic reperfusion in order to measure SOD and MDA. Coronary flow, coronary resistance and platelet aggregation rate were tested. Results and Conclusion: The protective effect of indapamide and addition,apamil amy include: (1 )antioxide and free - radical scavenging; (2) dilating coroner artery. In addition, indapamide can decrease platelet aggregation rate.
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The protective effect of indapndde and verapamil in myocardial ischemia and reperfusion injury in rabbit Langendorff heart

  • Department of Cardiovascular Medicine, First Affiliated Hospital, Inner Mongolia Medical College, Huhhot 010050

Abstract: The animal medels of isolated myochoial pehschemic reperfusion injury in rabbits using Langendorff apparatus were used to inquire into the protective effect of indapamide and verapamil. Methods: Twenty - one male rabbits were randomly divided into three groups (n=7 in each): control group, verapamil group and indapamide group. Isolated heaxts were reperfused after 40 min of global no - flow ischemia, Reperfusion oulflow fluid were collected at 15 min,30 min 60 min and 300 min after postischemic reperfusion in order to measure SOD and MDA. Coronary flow, coronary resistance and platelet aggregation rate were tested. Results and Conclusion: The protective effect of indapamide and addition,apamil amy include: (1 )antioxide and free - radical scavenging; (2) dilating coroner artery. In addition, indapamide can decrease platelet aggregation rate.

Liu Yuansheng, Sun Huikuan, Qiu Nengyong, Zhang Yanping. The protective effect of indapndde and verapamil in myocardial ischemia and reperfusion injury in rabbit Langendorff heart[J]. Journal of Pharmaceutical Practice and Service, 1998, (6): 322-325.
Citation: Liu Yuansheng, Sun Huikuan, Qiu Nengyong, Zhang Yanping. The protective effect of indapndde and verapamil in myocardial ischemia and reperfusion injury in rabbit Langendorff heart[J]. Journal of Pharmaceutical Practice and Service, 1998, (6): 322-325.
shu

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