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Volume 16 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1998  >  (5): 294-296

Liu Fang, Chen Ying, Wang Feizhen, Shen Wenzhao. Determination the content of carboplatin injection and stability tast[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 294-296.
Citation: Liu Fang, Chen Ying, Wang Feizhen, Shen Wenzhao. Determination the content of carboplatin injection and stability tast[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 294-296.
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Determination the content of carboplatin injection and stability tast

  • Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, 310013

  • A RP-HPLC method for the quantitative determination of carboplation injection has been developed by using YWG-C18 column, using pure water as mobile phase and deteced at 210nm. The uridine was used as internal standard. Under these condition, the retention of carboplatin and uridine was 6.5 and 10.5 minture,respectively (R > 1 .5). The method is simple,rapid and sensitive. The within-day and between-day precisions were 2. 35% (n = 5) and 3. 56% (n = 5) respectively. The stability test showed the carboplatin injection store at room tempoerature (< 40℃) and store in refrigerator(4℃-10℃)for two years, and kept away from light, the contents of carboplatin injection were not significantly changed.
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Determination the content of carboplatin injection and stability tast

  • Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, 310013

Abstract: A RP-HPLC method for the quantitative determination of carboplation injection has been developed by using YWG-C18 column, using pure water as mobile phase and deteced at 210nm. The uridine was used as internal standard. Under these condition, the retention of carboplatin and uridine was 6.5 and 10.5 minture,respectively (R > 1 .5). The method is simple,rapid and sensitive. The within-day and between-day precisions were 2. 35% (n = 5) and 3. 56% (n = 5) respectively. The stability test showed the carboplatin injection store at room tempoerature (< 40℃) and store in refrigerator(4℃-10℃)for two years, and kept away from light, the contents of carboplatin injection were not significantly changed.

Liu Fang, Chen Ying, Wang Feizhen, Shen Wenzhao. Determination the content of carboplatin injection and stability tast[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 294-296.
Citation: Liu Fang, Chen Ying, Wang Feizhen, Shen Wenzhao. Determination the content of carboplatin injection and stability tast[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 294-296.
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