Research progress of lncRNA MEG3 in tumorigenesis

DING Jianing; MA Jinyuan; ZHU Quangang

doi:10.3969/j.issn.1006-0111.2019.05.002

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2019 > 37(5): 390-393,421

DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002

Citation:

DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002

Research progress of lncRNA MEG3 in tumorigenesis

doi: 10.3969/j.issn.1006-0111.2019.05.002

1.
Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2.
Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China
3.
Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

Received Date: 2019-04-04
Rev Recd Date: 2019-06-11

Abstract

Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper.
- lncRNA,
- MEG3,
- epigenetic regulation,
- tumor,
- antioncogene

References

[1]	SANCHEZ CALLE A,KAWAMURA Y,YAMAMOTO Y,et al.Emerging roles of long non-coding RNA in cancer[J].Cancer Sci,2018,109(7):2093-2100.
[2]	KUMAR M M,GOYAL R.LncRNA as a therapeutic target for angiogenesis[J].Curr Top Med Chem,2017,17(15):1750-1757.
[3]	WEIDLE U H,BIRZELE F,KOLLMORGEN G,et al.Long non-coding RNAs and their role in metastasis[J].CGP,2017,14(3):143-160.
[4]	PALMIERI G,PALIOGIANNIS P,SINI M C,et al.Long non-coding RNA CASC₂ in human cancer[J].Crit Rev Oncol Hematol,2017,111:31-38.
[5]	BRANNAN C I,DEES E C,INGRAM R S,et al.The product of the H₁₉ gene may function as an RNA[J].Mol Cell Biol,1990,10(1):28-36.
[6]	LI T W,MO X Y,FU L Y,et al.Molecular mechanisms of long noncoding RNAs on gastric cancer[J].Oncotarget,2016,7(8):8601-8612.
[7]	WALLACE C,SMYTH D J,MAISURIA-ARMER M,et al.The imprinted DLK₁-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes[J].Nat Genet,2010,42(1):68-71.
[8]	SALLAM T,SANDHU J,TONTONOZ P.Long noncoding RNA discovery in cardiovascular disease:decoding form to function[J].Circ Res,2018,122(1):155-166.
[9]	FENG L,LIAO Y T,HE J C,et al.Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease[J].BMC Neurol,2018,18(1):4.
[10]	LI H,YU B Q,LI J F,et al.Characterization of differentially expressed genes involved in pathways associated with gastric cancer[J].PLoS One,2015,10(4):e0125013.
[11]	SONG H J,SUN W L,YE G L,et al.Long non——coding RNA expression profile in human gastric cancer and its clinical significances[J].J Transl Med,2013,11:225.
[12]	QIN Y,SUN W,ZHANG H,et al.LncRNA GAS₈-AS₁ inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer[J].Endocrine,2018,59(3):555-564.
[13]	ZHANG L G,ZHOU X K,ZHOU R J,et al.Long non-coding RNA LINC₀₀₆₇₃ promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205[J].Am J Cancer Res,2017,7(12):2536-2544.
[14]	ZHANG X,RICE K,WANG Y Y,et al.Maternally expressed gene 3(MEG3) noncoding ribonucleic acid:isoform structure,expression,and functions[J].Endocrinology,2010,151(3):939-947.
[15]	MIYOSHI N,WAGATSUMA H,WAKANA S,et al.Identification of an imprinted gene,Meg3/Gtl2 and its human homologue MEG3,first mapped on mouse distal chromosome 12 and human chromosome 14q[J].Genes Cells,2000,5(3):211-220.
[16]	ZHANG X,ZHOU Y L,MEHTA K R,et al.A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells[J].J Clin Endocrinol Metab,2003,88(11):5119-5126.
[17]	ZHAO J,ZHANG X,ZHOU Y L,et al.Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region[J].Int J Biochem Cell Biol,2006,38(10):1808-1820.
[18]	ZHOU Y L,ZHONG Y,WANG Y Y,et al.Activation of p53 by MEG3 non-coding RNA[J].J Biol Chem,2007,282(34):24731-24742.
[19]	KRUER T L,DOUGHERTY S M,REYNOLDS L,et al.Expression of the lncRNA maternally expressed gene 3(MEG3) contributes to the control of lung cancer cell proliferation by the rb pathway[J].PLoS One,2016,11(11):e0166363.
[20]	GORDON F E,NUTT C L,CHEUNSUCHON P,et al.Increased expression of angiogenic genes in the brains of mouse meg3-null embryos[J].Endocrinology,2010,151(6):2443-2452.
[21]	BENETATOS L,VARTHOLOMATOS G,HATZIMICHAEL E.MEG3 imprinted gene contribution in tumorigenesis[J].Int J Cancer,2011,129(4):773-779.
[22]	BOUCKENHEIMER J,ASSOU S,RIQUIER S,et al.Long non-coding RNAs in human early embryonic development and their potential in ART[J].Hum Reprod Update,2016,23(1):19-40.
[23]	CHEUNSUCHON P,ZHOU Y L,ZHANG X,et al.Silencing of the imprinted DLK₁-MEG3 locus in human clinically nonfunctioning pituitary adenomas[J].Am J Pathol,2011,179(4):2120-2130.
[24]	CHUNHAROJRITH P,NAKAYAMA Y,JIANG X B,et al.Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line[J].Mol Cell Endocrinol,2015,416:27-35.
[25]	ZHANG X,GEJMAN R,MAHTA A,et al.Maternally expressed gene 3,an imprinted noncoding RNA gene,is associated with meningioma pathogenesis and progression[J].Cancer Res,2010,70(6):2350-2358.
[26]	BRACONI C,KOGURE T,VALERI N,et al.MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer[J].Oncogene,2011,30(47):4750-4756.
[27]	MODALI S D,PAREKH V I,KEBEBEW E,et al.Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors[J].Mol Endocrinol,2015,29(2):224-237.
[28]	LU K H,LI W,LIU X H,et al.Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression[J].BMC Cancer,2013,13:461.
[29]	RIBARSKA T,BASTIAN K M,KOCH A,et al.Specific changes in the expression of imprinted genes in prostate cancer:implications for cancer progression and epigenetic regulation[J].Asian J Androl,2012,14(3):436-450.
[30]	RIBARSKA T,GOERING W,DROOP J,et al.Deregulation of an imprinted gene network in prostate cancer[J].Epigenetics,2014,9(5):704-717.
[31]	LUO G,WANG M,WU X,et al.Long non-coding RNA MEG3 inhibits cell proliferation and induces apoptosis in prostate cancer[J].Cell Physiol Biochem,2015,37(6):2209-2220.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Research progress of lncRNA MEG3 in tumorigenesis

1. Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

2. Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

3. Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

Received Date: 2019-04-04

Rev Recd Date: 2019-06-11

Key words:

Abstract: Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper.

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Reference (31)

[1]	SANCHEZ CALLE A,KAWAMURA Y,YAMAMOTO Y,et al.Emerging roles of long non-coding RNA in cancer[J].Cancer Sci,2018,109(7):2093-2100.
[2]	KUMAR M M,GOYAL R.LncRNA as a therapeutic target for angiogenesis[J].Curr Top Med Chem,2017,17(15):1750-1757.
[3]	WEIDLE U H,BIRZELE F,KOLLMORGEN G,et al.Long non-coding RNAs and their role in metastasis[J].CGP,2017,14(3):143-160.
[4]	PALMIERI G,PALIOGIANNIS P,SINI M C,et al.Long non-coding RNA CASC₂ in human cancer[J].Crit Rev Oncol Hematol,2017,111:31-38.
[5]	BRANNAN C I,DEES E C,INGRAM R S,et al.The product of the H₁₉ gene may function as an RNA[J].Mol Cell Biol,1990,10(1):28-36.
[6]	LI T W,MO X Y,FU L Y,et al.Molecular mechanisms of long noncoding RNAs on gastric cancer[J].Oncotarget,2016,7(8):8601-8612.
[7]	WALLACE C,SMYTH D J,MAISURIA-ARMER M,et al.The imprinted DLK₁-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes[J].Nat Genet,2010,42(1):68-71.
[8]	SALLAM T,SANDHU J,TONTONOZ P.Long noncoding RNA discovery in cardiovascular disease:decoding form to function[J].Circ Res,2018,122(1):155-166.
[9]	FENG L,LIAO Y T,HE J C,et al.Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease[J].BMC Neurol,2018,18(1):4.
[10]	LI H,YU B Q,LI J F,et al.Characterization of differentially expressed genes involved in pathways associated with gastric cancer[J].PLoS One,2015,10(4):e0125013.
[11]	SONG H J,SUN W L,YE G L,et al.Long non——coding RNA expression profile in human gastric cancer and its clinical significances[J].J Transl Med,2013,11:225.
[12]	QIN Y,SUN W,ZHANG H,et al.LncRNA GAS₈-AS₁ inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer[J].Endocrine,2018,59(3):555-564.
[13]	ZHANG L G,ZHOU X K,ZHOU R J,et al.Long non-coding RNA LINC₀₀₆₇₃ promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205[J].Am J Cancer Res,2017,7(12):2536-2544.
[14]	ZHANG X,RICE K,WANG Y Y,et al.Maternally expressed gene 3(MEG3) noncoding ribonucleic acid:isoform structure,expression,and functions[J].Endocrinology,2010,151(3):939-947.
[15]	MIYOSHI N,WAGATSUMA H,WAKANA S,et al.Identification of an imprinted gene,Meg3/Gtl2 and its human homologue MEG3,first mapped on mouse distal chromosome 12 and human chromosome 14q[J].Genes Cells,2000,5(3):211-220.
[16]	ZHANG X,ZHOU Y L,MEHTA K R,et al.A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells[J].J Clin Endocrinol Metab,2003,88(11):5119-5126.
[17]	ZHAO J,ZHANG X,ZHOU Y L,et al.Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region[J].Int J Biochem Cell Biol,2006,38(10):1808-1820.
[18]	ZHOU Y L,ZHONG Y,WANG Y Y,et al.Activation of p53 by MEG3 non-coding RNA[J].J Biol Chem,2007,282(34):24731-24742.
[19]	KRUER T L,DOUGHERTY S M,REYNOLDS L,et al.Expression of the lncRNA maternally expressed gene 3(MEG3) contributes to the control of lung cancer cell proliferation by the rb pathway[J].PLoS One,2016,11(11):e0166363.
[20]	GORDON F E,NUTT C L,CHEUNSUCHON P,et al.Increased expression of angiogenic genes in the brains of mouse meg3-null embryos[J].Endocrinology,2010,151(6):2443-2452.
[21]	BENETATOS L,VARTHOLOMATOS G,HATZIMICHAEL E.MEG3 imprinted gene contribution in tumorigenesis[J].Int J Cancer,2011,129(4):773-779.
[22]	BOUCKENHEIMER J,ASSOU S,RIQUIER S,et al.Long non-coding RNAs in human early embryonic development and their potential in ART[J].Hum Reprod Update,2016,23(1):19-40.
[23]	CHEUNSUCHON P,ZHOU Y L,ZHANG X,et al.Silencing of the imprinted DLK₁-MEG3 locus in human clinically nonfunctioning pituitary adenomas[J].Am J Pathol,2011,179(4):2120-2130.
[24]	CHUNHAROJRITH P,NAKAYAMA Y,JIANG X B,et al.Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line[J].Mol Cell Endocrinol,2015,416:27-35.
[25]	ZHANG X,GEJMAN R,MAHTA A,et al.Maternally expressed gene 3,an imprinted noncoding RNA gene,is associated with meningioma pathogenesis and progression[J].Cancer Res,2010,70(6):2350-2358.
[26]	BRACONI C,KOGURE T,VALERI N,et al.MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer[J].Oncogene,2011,30(47):4750-4756.
[27]	MODALI S D,PAREKH V I,KEBEBEW E,et al.Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors[J].Mol Endocrinol,2015,29(2):224-237.
[28]	LU K H,LI W,LIU X H,et al.Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression[J].BMC Cancer,2013,13:461.
[29]	RIBARSKA T,BASTIAN K M,KOCH A,et al.Specific changes in the expression of imprinted genes in prostate cancer:implications for cancer progression and epigenetic regulation[J].Asian J Androl,2012,14(3):436-450.
[30]	RIBARSKA T,GOERING W,DROOP J,et al.Deregulation of an imprinted gene network in prostate cancer[J].Epigenetics,2014,9(5):704-717.
[31]	LUO G,WANG M,WU X,et al.Long non-coding RNA MEG3 inhibits cell proliferation and induces apoptosis in prostate cancer[J].Cell Physiol Biochem,2015,37(6):2209-2220.

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Research progress of lncRNA MEG3 in tumorigenesis

doi: 10.3969/j.issn.1006-0111.2019.05.002

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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