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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(4): 314-317

MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006
Citation: MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006
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Study on the secondary metabolites of the fungus Chaetomium sp.

doi: 10.3969/j.issn.1006-0111.2019.04.006

  • Hospital 905 of PLA Navy, Shanghai 200052, China

  • Received Date: 2018-11-06
  • Rev Recd Date: 2019-02-25
  • Objective To investigate the secondary metabolites of the marine fungi Chaetomium sp. Methods The EtOAc extract of Chaetomium sp.fermentation was purified by repeated column chromatography on silica gel,Sephadex LH-20,and high-performance liquid chromatography.The isolated compounds were structurally elucidated by spectroscopic analysis and by comparison with literatures previously reported. Results Four nonanolides including botryolides A,B,D,decarestrictine I,together with one sesquiterpene trichothecolone were isolated and structurally elucidated. Conclusion 5 Compounds were reported for the first time from the marine fungi Chaetomium sp.
  • [1] NEWMAN D J,CRAGG G M,SNADER K M.The influence of natural products upon drug discovery[J].Nat Prod Rep,2000,17(3):215-234.
    [2] JENSEN P R,MOORE B S,FENICAL W.The marine actinomycete genus Salinispora:a model organism for secondary metabolite discovery[J].Nat Prod Rep,2015,32(5):738-751.
    [3] FENICAL W,JENSEN P R.Developing a new resource for drug discovery:marine actinomycete bacteria[J].Nat Chem Biol,2006,2(12):666-673.
    [4] HOU X M,XU R F,GU Y C,et al.Biological and chemical diversity of coral-derived microorganisms[J].Curr Med Chem,2015,22(32):3707-3762.
    [5] ZHAO C Y,ZHU H T,ZHU W M.New marine natural products of microbial origin from 2010 to 2013[J].Chin J Org Chem (有机化学),2013,33(6):1195-1234.
    [6] KIRK P M,CANNON P F,DAVID J C,et al.Ainsworth and Bisby's dictionary of the fungi,9th Edition,[M].CABI Publishing,2001.
    [7] FATIMA N,MUKHTAR U,IHSAN UL H,et al.Biologicalevaluation of endophytic fungus Chaetomium sp.NF15 of Justicia adhatoda L.:A potential candidate for drug discovery[J].Jundishapur J Microbiol,2016,9(6):e29978.
    [8] JIAO R H,XU S,LIU J Y,et al.Chaetominine,a cytotoxic alkaloid produced by endophytic Chaetomium sp.IFB-E015[J].Org Lett,2006,8(25):5709-5712.
    [9] SY A A,SWENSON D C,GLOER J B,et al.Botryolides A-E,decarestrictine analogues from a fungicolous Botryotrichum sp.(NRRL 38180)[J].J Nat Prod,2008,71(3):415-419.
    [10] RADHA KRISHNA P,RAO T J.Total synthesis of decarestrictine I and botryolide B via RCM protocol[J].Org Biomol Chem,2010,8(14):3130-3132.
    [11] LOUKACI A,KAYSER O,BINDSEIL K,et al.New trichothecenes isolated from Holarrhena floribunda[J].J Nat Prod,2000,63(1):52-56.
    [12] SUN P,LU S,REE T,et al.Nonanolides ofnatural origin:structure,synthesis,and biological activity[J].Curr Med Chem,2012,19:3417-3455.
    [13] YADAV J S,VENKATESH M,KUMAR A S,et al.Astereoselective total synthesis of decarestrictine I[J].Helv Chim Acta,2014,97(6):830-838.
    [14] PHILIPPS S,MAYER M,G HRT A,et al.[P],EP,0497300A12,1992.
    [15] WU Q,DOHNAL V,KUCA K,et al.Trichothecenes:structure-toxic activity relationships[J],Curr Drug Metab,2013,14(6):641-660.
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Study on the secondary metabolites of the fungus Chaetomium sp.

doi: 10.3969/j.issn.1006-0111.2019.04.006
  • Hospital 905 of PLA Navy, Shanghai 200052, China
  • Received Date: 2018-11-06
  • Rev Recd Date: 2019-02-25

Abstract: Objective To investigate the secondary metabolites of the marine fungi Chaetomium sp. Methods The EtOAc extract of Chaetomium sp.fermentation was purified by repeated column chromatography on silica gel,Sephadex LH-20,and high-performance liquid chromatography.The isolated compounds were structurally elucidated by spectroscopic analysis and by comparison with literatures previously reported. Results Four nonanolides including botryolides A,B,D,decarestrictine I,together with one sesquiterpene trichothecolone were isolated and structurally elucidated. Conclusion 5 Compounds were reported for the first time from the marine fungi Chaetomium sp.

MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006
Citation: MENG Hui, XU Yong. Study on the secondary metabolites of the fungus Chaetomium sp.[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006
shu

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