Anti-arthritis effects of matrine derivative in rats

XIE Fangyuan; WANG Tiantian; XU Weiheng; XIN Bao; ZHOU Xuwei; ZHANG Guoqing

doi:10.3969/j.issn.1006-0111.2019.03.010

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To study the therapeutic effects of matrine derivative M19 on type Ⅱcollagen-induced arthritis (CIA) in rats. Methods Sixty rats were randomly divided into six groups:blank group,model group,indomethacin treatment group,M19 low,medium and high dose groups (2.5,5,10 mg/kg).The paw swelling,arthritis index (AI) and body weight were measured for CIA rats.The histopathological changes of joints and synovial tissue were observed by HE staining.The bone destruction was observed with micro-CT. Results Matrine derivative M19 reduced the paw swelling,increased body weight,inhibited inflammatory cell infiltration,ameliorated synovial tissue and bone destruction in CIA rats. Conclusion Matrine derivative M19 has the certain therapeutic effects on CIA.

Anti-arthritis effects of matrine derivative in rats

1. Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University, Shanghai 200438, China

2. Department of Microbiology and Biochemical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai 200433, China

Received Date: 2018-11-08

Rev Recd Date: 2018-12-19

Key words:

Abstract: Objective To study the therapeutic effects of matrine derivative M19 on type Ⅱcollagen-induced arthritis (CIA) in rats. Methods Sixty rats were randomly divided into six groups:blank group,model group,indomethacin treatment group,M19 low,medium and high dose groups (2.5,5,10 mg/kg).The paw swelling,arthritis index (AI) and body weight were measured for CIA rats.The histopathological changes of joints and synovial tissue were observed by HE staining.The bone destruction was observed with micro-CT. Results Matrine derivative M19 reduced the paw swelling,increased body weight,inhibited inflammatory cell infiltration,ameliorated synovial tissue and bone destruction in CIA rats. Conclusion Matrine derivative M19 has the certain therapeutic effects on CIA.

HTML

Reference (17)

[1]	UHLIG T,MOE R H,KVIEN T K.The burden of disease in rheumatoid arthritis[J].Pharmacoeconomics,2014,32(9):841-851.
[2]	BARTOK B,FIRESTEIN G S.Fibroblast-like synoviocytes:key effector cells in rheumatoid arthritis[J].Immunol Rev,2010,233(1):233-255.
[3]	KIM S C,SOLOMON D H,LIU J,et al. Risk of venous thromboembolism in patients with rheumatoid arthritis:initiating disease-modifying antirheumatic drugs[J].Am J Med,2015,128(5):539.e7-17.
[4]	LIU H M,WANG K J.Therapeutic effect of Captopril on rheumatoid arthritis in rats[J].Asian Pac J Trop Med,2014,7(12):996-999.
[5]	周静,张弦,钱海兵.类风湿性关节炎发病机制的研究进展[J].贵阳中医学院学报,2014,36(5):44-47.
[6]	梁燕,邹豪.类风湿性关节炎药物治疗研究进展[J].海军医学杂志,2014,35(4):332-333.
[7]	LIU N,KAN Q C,ZHANG X J,et al.Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis[J].Exp Mol Pathol,2014,97(3):470-476.
[8]	SUN N,WANG Z W,WU C H,et al.Antiviral activity and underlying molecular mechanisms of matrine against porcine reproductive and respiratory syndrome virus in vitro[J].Res Vet Sci,2014,96(2):323-327.
[9]	WANG Y,ZHANG S,LIU J,et al.Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial-mesenchymal transition[J].Mol Med Rep,2018,18(1):911-919.
[10]	KAN Q C,LV P,ZHANG X J,et al.Matrine protects neuro-axon from CNS inflammation-induced injury[J].Exp Mol Pathol,2015,98(1):124-130.
[11]	HU H,WANG S,ZHANG C,et al.Synthesis and in vitro inhibitory activity of matrine derivatives towards pro-inflammatory cytokines[J].Bioorg Med Chem Lett,2010,20(24):7537-7539.
[12]	XU W H,HU H G,TIAN Y,et al.Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis[J].Hepatology,2014,60(2):648-660.
[13]	XU J,WANG K Q,XU W H,et al.The matrine derivate MASM prolongs survival,attenuates inflammation,and reduces organ injury in murine established lethal sepsis[J].J Infect Dis,2016,214(11):1762-1772.
[14]	LIU Y,QI Y,BAI Z H,et al.A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways[J].Acta Pharmacol Sin,2017,38(1):120-132.
[15]	倪晨旭,齐阳,许维恒,等.苦参碱衍生物M19对于肿瘤细胞转移的抑制作用[J].现代肿瘤医学,2016,24(21):3341-3344.
[16]	CHEN X,ZHI X,CAO L,et al.Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis[J].Cell Death Dis,2017,8(9):e3037.
[17]	XU J,QI Y,XU W H,et al.Matrine derivate MASM suppresses LPS-induced phenotypic and functional maturation of murine bone marrow-derived dendritic cells[J].Int Immunopharmacol,2016,36:59-66.

Message Board

Anti-arthritis effects of matrine derivative in rats

doi: 10.3969/j.issn.1006-0111.2019.03.010

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views