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Volume 37 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(3): 226-230

CHEN Jing, CHEN Mingzhu, HUANG Yuxiang, CHENG Jing, HUANG Yaping. Effects of total flavonoids from Armeniaca mume on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 226-230. doi: 10.3969/j.issn.1006-0111.2019.03.007
Citation: CHEN Jing, CHEN Mingzhu, HUANG Yuxiang, CHENG Jing, HUANG Yaping. Effects of total flavonoids from Armeniaca mume on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 226-230. doi: 10.3969/j.issn.1006-0111.2019.03.007
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Effects of total flavonoids from Armeniaca mume on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress

doi: 10.3969/j.issn.1006-0111.2019.03.007

  • Department of Pharmacology, Quanzhou Medical College, Quanzhou 362000, China

  • Received Date: 2018-06-28
  • Rev Recd Date: 2019-01-20
  • Objective To explore the possible mechanism of total flavonoids from Armeniaca mume(TFAM) through observing its effects on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress. Methods The SD rats were randomly divided into normal saline group,model group,positive control group (fluoxetine,20 mg/kg),low-dose treatment group (TD-TFAM,80 mg/kg),middle-dose treatment group (TZ-TFAM,160 mg/kg) and high-dose treatment group (TG-TFAM,240 mg/kg),total 6 groups.Except the normal saline group,the rats in all other groups were given chronic unpredictable mild stress (CUMS) for 28 d to build the depression models,and then were randomly assigned.The antidepressant effects were evaluated by index such as growth in weight,sucrose preference and open-field test.Its effects on neuroendocrine were evaluated by contents of noradrenaline (NA),5-hydroxytryptamine (5-HT),adrenocorticotropic hormone (ACTH) and corticosterone (CORT) in the hippocampus and prefrontal cortex through enzyme linked immunosorbent assay (ELISA). Also,the enzymes activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in the serum and striatum were measured to estimate its influences on oxidative stress. Results TFAM significantly increased the weight growth of CUMS rats,promoted the percentage of sugar water preference,reversed open-field test score,increased the contents of 5-HT and NA but reduced the contents of ACTH and CORT in the hippocampus and prefrontal cortex of rats,while the activities of SOD and GSH-Px in serum and striatum were up-regulated. Conclusion The anti-depressant mechanism of TFAM might be related to promoting the secretion of monoamines,regulating the function of hypothalamic-pituitary-adrenal (HPA) axis and removing free radicals in rats.
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Effects of total flavonoids from Armeniaca mume on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress

doi: 10.3969/j.issn.1006-0111.2019.03.007
  • Department of Pharmacology, Quanzhou Medical College, Quanzhou 362000, China
  • Received Date: 2018-06-28
  • Rev Recd Date: 2019-01-20

Abstract: Objective To explore the possible mechanism of total flavonoids from Armeniaca mume(TFAM) through observing its effects on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress. Methods The SD rats were randomly divided into normal saline group,model group,positive control group (fluoxetine,20 mg/kg),low-dose treatment group (TD-TFAM,80 mg/kg),middle-dose treatment group (TZ-TFAM,160 mg/kg) and high-dose treatment group (TG-TFAM,240 mg/kg),total 6 groups.Except the normal saline group,the rats in all other groups were given chronic unpredictable mild stress (CUMS) for 28 d to build the depression models,and then were randomly assigned.The antidepressant effects were evaluated by index such as growth in weight,sucrose preference and open-field test.Its effects on neuroendocrine were evaluated by contents of noradrenaline (NA),5-hydroxytryptamine (5-HT),adrenocorticotropic hormone (ACTH) and corticosterone (CORT) in the hippocampus and prefrontal cortex through enzyme linked immunosorbent assay (ELISA). Also,the enzymes activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in the serum and striatum were measured to estimate its influences on oxidative stress. Results TFAM significantly increased the weight growth of CUMS rats,promoted the percentage of sugar water preference,reversed open-field test score,increased the contents of 5-HT and NA but reduced the contents of ACTH and CORT in the hippocampus and prefrontal cortex of rats,while the activities of SOD and GSH-Px in serum and striatum were up-regulated. Conclusion The anti-depressant mechanism of TFAM might be related to promoting the secretion of monoamines,regulating the function of hypothalamic-pituitary-adrenal (HPA) axis and removing free radicals in rats.

CHEN Jing, CHEN Mingzhu, HUANG Yuxiang, CHENG Jing, HUANG Yaping. Effects of total flavonoids from Armeniaca mume on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 226-230. doi: 10.3969/j.issn.1006-0111.2019.03.007
Citation: CHEN Jing, CHEN Mingzhu, HUANG Yuxiang, CHENG Jing, HUANG Yaping. Effects of total flavonoids from Armeniaca mume on neuroendocrine and oxidative stress of rats with depression induced by chronic mild stress[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 226-230. doi: 10.3969/j.issn.1006-0111.2019.03.007
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