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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(2): 188-192

DENG Dongmei, CHEN Xiaohong, YANG Xue, LI Bin. Literature cluster analysis of adverse drug reactions and adverse drug events in children using aminopyrine[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 188-192. doi: 10.3969/j.issn.1006-0111.2019.02.018
Citation: DENG Dongmei, CHEN Xiaohong, YANG Xue, LI Bin. Literature cluster analysis of adverse drug reactions and adverse drug events in children using aminopyrine[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 188-192. doi: 10.3969/j.issn.1006-0111.2019.02.018
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Literature cluster analysis of adverse drug reactions and adverse drug events in children using aminopyrine

doi: 10.3969/j.issn.1006-0111.2019.02.018
  • 1.

    Department of Pharmacy, Institute of Field Surgery Research, Chongqing 400042, China

  • 2.

    Department of Pharmacy, Chongqing Health Center for Women and Children, Chongqing 400013, China

  • Received Date: 2018-08-30
  • Rev Recd Date: 2018-10-08
  • Objective To systematically evaluate the adverse drug reactions(ADR) and the Adverse drug events(ADE) of children using different aminopyrine in order to know the distribution of ADR and ADE, including the organ distribution, severity distribution, composition and influential factors of ADR and ADE. Methods Literature was retrieved in electronic databases covering CNKI,VIP, WANFANG data,CBM, Embase and PubMed, aminopyrine, analgin, medicine with the components of aminopyrine, and adverse drug reactions, adverse drug events, allergies etc. were taken as free words for comprehensive search. According to the criteria of inclusion and exclusion, the data were selected and collected. The total number and composition ratio of aminopyrine's ADR and ADE were calculated and the differences between the analgin, compound aminopyrine and the components of aminopyrine were analyzed according to different categories (age, drug allergy history, organ system involved, combination therapy, etc.). Results ① A total of 484 Chinese literatures were included, including 555 cases，there were 205 cases of children;② A total of 70 English literatures were included, including 73 cases, there were 34 cases of children;③ The ADR/ADE reported in Chinese and English literatures mainly involving the hematopoietic system, mucocutaneous system, urinary system, circulatory system which led to systemic reactions such as shock. The prognosis varies, with 174 cases recovered(72.80%), 30 cases death (12.55%)and 14 cases (5.86%) of the outcome were bone marrow transplantation, finger and toe amputation, subtotal gastrectomy and other serious adverse reactions. ④ most of the adverse reactions of the dose for the regular dose, but there were also over-dose medical staff caused by adverse events. Conclusion The use of aminopyrine might cause serious damage to children's hematopoietic system and urinary system, with serious adverse reactions and even deaths reported annually. It was suggested that aminopyrine as a potentially lethal drug should be withdrawal quickly.
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    [8] 白淑霞, 李文芳, 李智慧,等.安乃近致暴发性紫癜1例[J].医药导报, 2011,30(7):943.
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Literature cluster analysis of adverse drug reactions and adverse drug events in children using aminopyrine

doi: 10.3969/j.issn.1006-0111.2019.02.018
  • 1. Department of Pharmacy, Institute of Field Surgery Research, Chongqing 400042, China
  • 2. Department of Pharmacy, Chongqing Health Center for Women and Children, Chongqing 400013, China
  • Received Date: 2018-08-30
  • Rev Recd Date: 2018-10-08

Abstract: Objective To systematically evaluate the adverse drug reactions(ADR) and the Adverse drug events(ADE) of children using different aminopyrine in order to know the distribution of ADR and ADE, including the organ distribution, severity distribution, composition and influential factors of ADR and ADE. Methods Literature was retrieved in electronic databases covering CNKI,VIP, WANFANG data,CBM, Embase and PubMed, aminopyrine, analgin, medicine with the components of aminopyrine, and adverse drug reactions, adverse drug events, allergies etc. were taken as free words for comprehensive search. According to the criteria of inclusion and exclusion, the data were selected and collected. The total number and composition ratio of aminopyrine's ADR and ADE were calculated and the differences between the analgin, compound aminopyrine and the components of aminopyrine were analyzed according to different categories (age, drug allergy history, organ system involved, combination therapy, etc.). Results ① A total of 484 Chinese literatures were included, including 555 cases，there were 205 cases of children;② A total of 70 English literatures were included, including 73 cases, there were 34 cases of children;③ The ADR/ADE reported in Chinese and English literatures mainly involving the hematopoietic system, mucocutaneous system, urinary system, circulatory system which led to systemic reactions such as shock. The prognosis varies, with 174 cases recovered(72.80%), 30 cases death (12.55%)and 14 cases (5.86%) of the outcome were bone marrow transplantation, finger and toe amputation, subtotal gastrectomy and other serious adverse reactions. ④ most of the adverse reactions of the dose for the regular dose, but there were also over-dose medical staff caused by adverse events. Conclusion The use of aminopyrine might cause serious damage to children's hematopoietic system and urinary system, with serious adverse reactions and even deaths reported annually. It was suggested that aminopyrine as a potentially lethal drug should be withdrawal quickly.

DENG Dongmei, CHEN Xiaohong, YANG Xue, LI Bin. Literature cluster analysis of adverse drug reactions and adverse drug events in children using aminopyrine[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 188-192. doi: 10.3969/j.issn.1006-0111.2019.02.018
Citation: DENG Dongmei, CHEN Xiaohong, YANG Xue, LI Bin. Literature cluster analysis of adverse drug reactions and adverse drug events in children using aminopyrine[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 188-192. doi: 10.3969/j.issn.1006-0111.2019.02.018
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