ZHANG Limin, CHEN Yufeng, ZHAN Ying, WU Xiaodan, ZHOU Yuhong. Metabonomics study on the antihypertensive mechanism of lactobacillus and bifidobacterium in the spontaneous hypertensive rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 141-145. doi: 10.3969/j.issn.1006-0111.2019.02.008
| Citation:
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ZHANG Limin, CHEN Yufeng, ZHAN Ying, WU Xiaodan, ZHOU Yuhong. Metabonomics study on the antihypertensive mechanism of lactobacillus and bifidobacterium in the spontaneous hypertensive rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 141-145. doi: 10.3969/j.issn.1006-0111.2019.02.008
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Metabonomics study on the antihypertensive mechanism of lactobacillus and bifidobacterium in the spontaneous hypertensive rats
- 1.
Huadong Hospital Affiliated to Fudan University, Shanghai 200050, China
- 2.
General Hospital of Shenyang Military Area Command, Shenyang 110016, China
- 3.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
- Received Date: 2018-08-03
- Rev Recd Date:
2018-11-30
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Abstract
Objective To explore the possible mechanism of synergistic effect of synbiotic preparations by regulating intestinal flora to achieve antihypertensive effect by the metabolomics-related techniques. Methods Fourteen spontaneously hypertensive rats were randomly divided into two groups,7 rats in each of the model group and the treatment group,and another 7 Wistar Kyoto rats were used as the control group.Ileum metabolic profiling among the control group,Spontaneous hypertension model group and symbiotic treatment group were analyzed by ultra-high performance liquid chromatography coupled with tandem quadrupole time of flight mass spectrometry (UHPLC-Q-TOF MS).The potential biomarkers for the treatment of spontaneous hypertension were selected. Results In additional,27 metabolites with significant differences between the control and model group were identified by analysis of metabonomics.Among these metabolites,LysoPE and PC could be significantly re-regulated in the treatment group,compared with the model group. Conclusion Synbiotics could improve the status of spontaneous hypertension by changing the structure of the intestinal microbiota,regulating LysoPE and PC-related signaling pathways.Metabolomics could help to understand the pathogenesis of essential hypertension and the hypotensive mechanism of synbiotics at the molecular level.
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