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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(2): 135-140,150

HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
Citation: HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
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Formulation optimization for multi-purpose protective cream

doi: 10.3969/j.issn.1006-0111.2019.02.007
  • 1.

    Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China

  • Received Date: 2018-10-29
  • Rev Recd Date: 2019-01-02
  • Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability. Methods The mass fraction of the film former VP/Hexadecene copolymer (Antaron V-216) in the formulation was optimized through the measurement of SPF value,critical wavelength and water resistance.Based on viscosity,centrifugal stability and freeze-thaw stability,the central composite design-response surface method was used to optimize the mass fraction of two emulsifiers and CaCl2 aqueous solution in the cream. Results When the film former Antaron V-216 has a mass fraction of 3%,the SPF value of the cream is significantly increased.When the mass fraction of emulsifier lauryl PEG/PPG-18/18 methicone (DC5200) is 0.76%,the mass fraction of emulsifier cetyl PEG/PPG-10/1 dimethicone (EM180) is 2.32% and the mass fraction of CaCl2 aqueous solution is 44.86%,the cream has suitable viscosity and good stability. Conclusion The optimized formulation has high water resistance and SPF value,suitable viscosity and good stability.
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    [4] BOULWARE D R.A randomized,controlled field trial for the prevention of jellyfish stings witha topical sting inhibitor[J].J Travel Med,2006,13(3):166-171.
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    [13] 常明泉,王刚,汪依林,等.派莎防晒霜体外抗水效能的测定[J].中国药房,2010(33):3109-3110.
    [14] HEINRICH U,TRONNIER H,KOCKOTT D,et al.Comparison of sun protection factors determined by an invivo,and different invitro,methodologies:a study with 58 different commercially available sunscreen products[J].Int J Cosmet Sci,2004,26(2):79-89.
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Formulation optimization for multi-purpose protective cream

doi: 10.3969/j.issn.1006-0111.2019.02.007
  • 1. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China
  • Received Date: 2018-10-29
  • Rev Recd Date: 2019-01-02

Abstract: Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability. Methods The mass fraction of the film former VP/Hexadecene copolymer (Antaron V-216) in the formulation was optimized through the measurement of SPF value,critical wavelength and water resistance.Based on viscosity,centrifugal stability and freeze-thaw stability,the central composite design-response surface method was used to optimize the mass fraction of two emulsifiers and CaCl2 aqueous solution in the cream. Results When the film former Antaron V-216 has a mass fraction of 3%,the SPF value of the cream is significantly increased.When the mass fraction of emulsifier lauryl PEG/PPG-18/18 methicone (DC5200) is 0.76%,the mass fraction of emulsifier cetyl PEG/PPG-10/1 dimethicone (EM180) is 2.32% and the mass fraction of CaCl2 aqueous solution is 44.86%,the cream has suitable viscosity and good stability. Conclusion The optimized formulation has high water resistance and SPF value,suitable viscosity and good stability.

HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
Citation: HAN Ling, FAN Li, ZHANG He, LÜ Lei, ZOU Hao, LU Ying. Formulation optimization for multi-purpose protective cream[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 135-140,150. doi: 10.3969/j.issn.1006-0111.2019.02.007
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