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Volume 36 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(6): 522-528

NI Xiaoxia, LIU Xiaoling, YE Caifa, WANG Qingfen. Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 522-528. doi: 10.3969/j.issn.1006-0111.2018.06.010
Citation: NI Xiaoxia, LIU Xiaoling, YE Caifa, WANG Qingfen. Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 522-528. doi: 10.3969/j.issn.1006-0111.2018.06.010
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Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty

doi: 10.3969/j.issn.1006-0111.2018.06.010

  • The Pharmacy Department, the 175 th Hospital of PLA, the Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, China

  • Received Date: 2018-01-19
  • Rev Recd Date: 2018-09-14
  • Objective To establish a gas chromatography (GC) method to determine the contents of camphor and menthol in compound camphor liniment and to evaluate the uncertainty. Methods Thermo TG-WAXMS (30.0 m×0.25 mm, 0.5 μm) and FID were used with naphtalinas as internal standard. The uncertainty sources of measurement were analyzed and a mathematical model was established to calculate the combined standard uncertainty and the expanded uncertainty. Results A good linear relationship was observed in the concentration range of 8.56-85.6μg/ml for camphor and 11.2-112.0 μg/ml for menthol, the average recoveries were 100.20% and 99.65% with RSD 0.892% and 1.369% (n=9). The expanded uncertainty U95 were 0.630 mg/ml (k=2), 0.656 mg/ml (k=2), The content of camphor was (20.74±0.602) mg/ml and menthol was (20.48±1.336) mg/ml. Conclusion The method is accurate, sensitive. It has good repeatability for controlling the quality of camphor and menthol in compound camphor liniment. The mathematic model of uncertainty can be used to improve the assay accuracy.
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Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty

doi: 10.3969/j.issn.1006-0111.2018.06.010
  • The Pharmacy Department, the 175 th Hospital of PLA, the Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, China
  • Received Date: 2018-01-19
  • Rev Recd Date: 2018-09-14

Abstract: Objective To establish a gas chromatography (GC) method to determine the contents of camphor and menthol in compound camphor liniment and to evaluate the uncertainty. Methods Thermo TG-WAXMS (30.0 m×0.25 mm, 0.5 μm) and FID were used with naphtalinas as internal standard. The uncertainty sources of measurement were analyzed and a mathematical model was established to calculate the combined standard uncertainty and the expanded uncertainty. Results A good linear relationship was observed in the concentration range of 8.56-85.6μg/ml for camphor and 11.2-112.0 μg/ml for menthol, the average recoveries were 100.20% and 99.65% with RSD 0.892% and 1.369% (n=9). The expanded uncertainty U95 were 0.630 mg/ml (k=2), 0.656 mg/ml (k=2), The content of camphor was (20.74±0.602) mg/ml and menthol was (20.48±1.336) mg/ml. Conclusion The method is accurate, sensitive. It has good repeatability for controlling the quality of camphor and menthol in compound camphor liniment. The mathematic model of uncertainty can be used to improve the assay accuracy.

NI Xiaoxia, LIU Xiaoling, YE Caifa, WANG Qingfen. Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 522-528. doi: 10.3969/j.issn.1006-0111.2018.06.010
Citation: NI Xiaoxia, LIU Xiaoling, YE Caifa, WANG Qingfen. Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 522-528. doi: 10.3969/j.issn.1006-0111.2018.06.010
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