Pharmacodynamic study of total celosins on anti-hyperlipidemia

WU Wendan; LIANG Lin; TANG Ying; NI Hailai; GUO Meili

doi:10.3969/j.issn.1006-0111.2018.06.004

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Objective To study the effect of total saponin (CES) on lipid metabolism in hyperlipidemic animals. Methods Golden hamster and rabbit hyperlipidemia animal models were established for this study.Both hyperlipidemia models were achieved by feeding high fat diet. The blood, hepatic lipid parameters and lipid peroxidation index were detected.Liver pathological changes were recorded. Results CES were orally administered to golden hamster hyperlipidemia model for two weeks at doses of 10-90 mg/kg. TC, TG and LDL-c were significantly reduced both in the serum and liver.In rabbit hyperlipidemia model, CES was orally administered at 6.0-24.0 mg/kg. Serum TC and LDL-c were reduced at day 10.Significant reduction of serum TC, LDL-c levels (P<0.01) and TG content (P<0.05) were observed after 20 and 30 days.This lipid-lowing effect was long lasting and stable. At the meantime, CES can also decrease the liver tissue TC, TG content (P<0.05) and MDA, LPS content (P<0.05). Pathological section showed that fat was significantly accumulated in the liver cell cytoplasm in rabbit model group. The liver cells were damaged. Large area of spotty necrosis was observed. Fat accumulation in the cytoplasm was significantly decreased in CES groups with dose dependent manner. With increased CES dose, liver damage was ameliorated. Conclusion CES can effectively reduce lipids in different animal hyperlipidemia models. This effect may be related to the decrease of the content of MDA and LPS in liver.

Pharmacodynamic study of total celosins on anti-hyperlipidemia

1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Department of Preventive Health Care, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Received Date: 2018-03-29

Rev Recd Date: 2018-06-20

Key words:

Abstract: Objective To study the effect of total saponin (CES) on lipid metabolism in hyperlipidemic animals. Methods Golden hamster and rabbit hyperlipidemia animal models were established for this study.Both hyperlipidemia models were achieved by feeding high fat diet. The blood, hepatic lipid parameters and lipid peroxidation index were detected.Liver pathological changes were recorded. Results CES were orally administered to golden hamster hyperlipidemia model for two weeks at doses of 10-90 mg/kg. TC, TG and LDL-c were significantly reduced both in the serum and liver.In rabbit hyperlipidemia model, CES was orally administered at 6.0-24.0 mg/kg. Serum TC and LDL-c were reduced at day 10.Significant reduction of serum TC, LDL-c levels (P<0.01) and TG content (P<0.05) were observed after 20 and 30 days.This lipid-lowing effect was long lasting and stable. At the meantime, CES can also decrease the liver tissue TC, TG content (P<0.05) and MDA, LPS content (P<0.05). Pathological section showed that fat was significantly accumulated in the liver cell cytoplasm in rabbit model group. The liver cells were damaged. Large area of spotty necrosis was observed. Fat accumulation in the cytoplasm was significantly decreased in CES groups with dose dependent manner. With increased CES dose, liver damage was ameliorated. Conclusion CES can effectively reduce lipids in different animal hyperlipidemia models. This effect may be related to the decrease of the content of MDA and LPS in liver.

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Pharmacodynamic study of total celosins on anti-hyperlipidemia

doi: 10.3969/j.issn.1006-0111.2018.06.004

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