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Volume 36 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(5): 438-442,452

ZHU Bin, LI Na, CHEN Qing, YANG Jie, YANG Yang. Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 438-442,452. doi: 10.3969/j.issn.1006-0111.2018.05.012
Citation: ZHU Bin, LI Na, CHEN Qing, YANG Jie, YANG Yang. Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 438-442,452. doi: 10.3969/j.issn.1006-0111.2018.05.012
shu

Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer

doi: 10.3969/j.issn.1006-0111.2018.05.012

  • Department of Pharmacy, Huaihai Hospital Affiliated to Xuzhou Medical University/No. 97 Hospital of PLA, Xuzhou, 221004, China

  • Received Date: 2017-12-19
  • Rev Recd Date: 2018-04-02
  • Objective To study the therapeutic effects of Yangwei granules on experimental gastric ulcer. Methods Four animal models of experimental gastric ulcer included water immersion stress and acetic acid induced gastric ulcer in rats, indomethacin and reserpine induced gastric ulcer in mice were used to observe the therapeutical effects of Yangwei granules on experimental gastric ulcer. The animal model of acetic acid induced writhing reaction test in mice was used to observe the analgesia effect. Results Yangwei granules of gavage administration had good protection effect on four animal models of experimental gastric ulcer. It reduced the degree of gastric mucosa damage and the ulcer index, inhibited the ulcer formation and lowered the ulcer incidence. It also had significant analgesic effect with reduced numbers of writhing reaction in mice model induced by acetic acid. Conclusion Yangwei granules had noticeable therapeutic effects for experimental gastric ulcer. It can be used to treat gastric and duodenal peptic ulcers.
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Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer

doi: 10.3969/j.issn.1006-0111.2018.05.012
  • Department of Pharmacy, Huaihai Hospital Affiliated to Xuzhou Medical University/No. 97 Hospital of PLA, Xuzhou, 221004, China
  • Received Date: 2017-12-19
  • Rev Recd Date: 2018-04-02

Abstract: Objective To study the therapeutic effects of Yangwei granules on experimental gastric ulcer. Methods Four animal models of experimental gastric ulcer included water immersion stress and acetic acid induced gastric ulcer in rats, indomethacin and reserpine induced gastric ulcer in mice were used to observe the therapeutical effects of Yangwei granules on experimental gastric ulcer. The animal model of acetic acid induced writhing reaction test in mice was used to observe the analgesia effect. Results Yangwei granules of gavage administration had good protection effect on four animal models of experimental gastric ulcer. It reduced the degree of gastric mucosa damage and the ulcer index, inhibited the ulcer formation and lowered the ulcer incidence. It also had significant analgesic effect with reduced numbers of writhing reaction in mice model induced by acetic acid. Conclusion Yangwei granules had noticeable therapeutic effects for experimental gastric ulcer. It can be used to treat gastric and duodenal peptic ulcers.

ZHU Bin, LI Na, CHEN Qing, YANG Jie, YANG Yang. Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 438-442,452. doi: 10.3969/j.issn.1006-0111.2018.05.012
Citation: ZHU Bin, LI Na, CHEN Qing, YANG Jie, YANG Yang. Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 438-442,452. doi: 10.3969/j.issn.1006-0111.2018.05.012
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