Research progress of <i>Cortex Phellodendri</i> in the chemical constituents and their pharmacological effects

LI Jiacheng; WU Lan; CAI Tongkai; CAO Yongbing; JIANG Yuanying

doi:10.3969/j.issn.1006-0111.2018.05.002

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Volume 36 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2018 > 36(5): 389-391,398

LI Jiacheng, WU Lan, CAI Tongkai, CAO Yongbing, JIANG Yuanying. Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 389-391,398. doi: 10.3969/j.issn.1006-0111.2018.05.002

Citation:

LI Jiacheng, WU Lan, CAI Tongkai, CAO Yongbing, JIANG Yuanying. Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 389-391,398. doi: 10.3969/j.issn.1006-0111.2018.05.002

Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects

doi: 10.3969/j.issn.1006-0111.2018.05.002

1.
Shanghai TCM-Integrated Hospital, Shanghai TCM-Integrated Research Institute of pulse tube disease, Shanghai 200082, China
2.
Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2018-04-20
Rev Recd Date: 2018-07-09

Abstract

Cortex phellodendri is a traditional Chinese medicine with the effects of clearing away heat, purging fire and dampness, detoxification and detumescence. Its main chemical constituents are flavonoids and alkaloids, which have many pharmacological effects, such as immunosuppressive, hypoglycemic and lowering blood pressure. In this paper, the chemical composition and pharmacological effects of cypress are reviewed in order to provide the references for further research and development of cypress.
- Cortex Phellodendri,
- chemical component,
- pharmacological effects

References

[1]	朱志明,赖潇潇, 苏慕霞.不同产地黄柏及关黄柏有效成分的含量测定[J].临床医学工程,2011,18(1):106-108.
[2]	闫玉鑫.川黄柏的抗肿瘤化学成分研究[J].云南师范大学学报(自然科学版),2015,35(3):75-78.
[3]	汤欢,向丽,赵莎,等.应用DNA条形码ITS2序列对市售药材黄柏的鉴定研究[J].世界科学技术-中医药现代化,2016,18(2):184-190.
[4]	WANG H,YAN G,ZHANG A,et al.Rapid discovery and global characterization of chemical constituents and rats metabolites of Phellodendri amurensis cortex by ultra-performance liquid chromatography-eleetrospray ionization/quadrupole-time-of-flight mass spectrometry coupled with pattern recognition approach[J].Analyst,2013,138(11):3303-3312.
[5]	WANG H,SUN H,ZHANG A,et al.Rapid identification and comparative analysis of the chemical constituents and metabolites of Phellodendri amurensis cortex and Zhibai Dihuang pill by uhra-performance liquid chromatography with quadrupole TOF-MS[J].J Sep Sci,2013,36(24):3874-3882.
[6]	LEE SH,KWAK SC,KIM DK,et al.Effects of Huang Bai(Phellodendri Cortex)and three other herbs on GnRH and GH levels in GTl-7 and GH3 cells[J].Evid Based Complement Alternat Med,2016,2016:9389028.
[7]	WANG W,ZU Y,FU Y,et al.In vitro antioxidant,antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr.from China[J].Am J Chin Med,2009,37(1):195-203.
[8]	SWANSON GP,JONES WE 3rd,HA CS,et al.Tolerance of Phellodendron amurense bark extract(Nexrutine) in patients with human prostate cancer[J]. Phytother Res,2015,29(1):40-42.
[9]	SUN H,WANG H,ZHANG A,et al.Chemical discrimination of cortex Phellodendri amurensis and cortex Phellodendri chinensis by multivariate analysis approach[J]. Pharmacogn Mag,2016,12(45):41-49.
[10]	藤田穆,和田桂二.黄柏成分(第一报)[J].药学杂志(日),1931,51(6):5061.
[11]	秦民坚,王衡奇.黄皮树树皮的化学成分研究[J].林产化学与工业,2003,23(4):42-46.
[12]	中华本草编委会.中华本草(精选本·上册)[M].上海:上海科学技术出版社,1998:10421.
[13]	张少君,罗时旋, 赵稷,等.关黄柏中总黄酮的提取工艺及抗氧化活性研究[J]. 黑龙江医药科学, 2015,38(3):11-13.
[14]	曾一,回瑞华,侯冬岩.黄柏中黄酮类化合物的提取及其抗氧化性分析[J]. 鞍山师范学院学报,2010, 12(6):60-62.
[15]	王本祥.现代中药药理与临床[M].天津:天津科学技术出版社, 2004:1385.
[16]	李跃辉,胡薏冰,王银,等.不同产区与采收期黄柏中小檗碱与黄柏碱含量对比研究[J].中国医药导报,2014,11(11):91-93.
[17]	陶晓倩,胡玉梅,王俨如,等. 39个中药材提取物对Aβ25-35诱导SH-SY5Y细胞损伤的保护作用筛选研究[J].世界科学技术(中医药现代化),2015,17(1):61-65.
[18]	廉莲,贾天柱.黄柏及其炮制品的抗痛风作用研究[J].安徽农业科学,2011,39(15):8911-8912+8932.
[19]	刘睿,胡家才.黄柏对尿酸性肾病大鼠的影响及机制[J].武汉大学学报(医学版),2011,32(2):180-182.
[20]	王君明,崔瑛,申玲玲,等.中药致药源性肝损伤的氧化应激机制研究进展[J].中国实验方剂学杂志,2011,17(5):247-249.
[21]	王秋红,杨欣,王蒙,等.黄芩与黄柏协同保护黄药子致肝毒性的实验研究[J].中国中药杂志,2016,41(5):898-903.
[22]	宋智琦,林熙然.中药黄柏、茯苓及栀子抗迟发型超敏反应作用的实验研究[J].中国皮肤性病学杂志,1997,11(3):143-144.
[23]	孔令东,杨澄,仇熙,等.黄柏炮制品清除氧自由基和抗脂质过氧化作用[J].中国中药杂志,2001,26(4):245-248.
[24]	毛燕欣,庄洁, 赵志刚.黄柏在皮肤科的临床应用与药理研究[J].中国中医药现代远程教育,2007,5(5):34-37.
[25]	SUN H,WANG H,ZHANG A,et al.Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation[J].OMICS,2015,19(3):186-195.
[26]	WANG W,LI Q,LIU Y,et al.Ionic liquid-aqueous solution ultrasonic-assisted extraction of three kinds of alkaloids from Phellodendron amurense Rupr and optimize conditions use response surface[J].Ultrason Sonochem,2015,24:13-18.
[27]	MOHAN V,AGARWAL R,SINGH RP.A novel alkaloid,evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells[J].Biochem Biophys Res Commun,2016,477(4):1065-1071.
[28]	BRIBI N,ALGIERI F, RODRIGUEZ-NOGALES A,et al.Intestinal anti-inflammatory effects of total alkaloid extract from Fumaria capreolata in the DNBS model of mice colitis and intestinal epithelial CMT93 cells[J].Phytomedicine,2016,23(9):901-913.
[29]	孙晖,李先娜,张颖,等.利用血液代谢组学研究关黄柏生物碱对慢性非细菌性前列腺炎模型大鼠的干预作用[J].世界科学技术(中医药现代化),2016,18(10):1709-1719.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects

1. Shanghai TCM-Integrated Hospital, Shanghai TCM-Integrated Research Institute of pulse tube disease, Shanghai 200082, China

2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2018-04-20

Rev Recd Date: 2018-07-09

Key words:

Abstract: Cortex phellodendri is a traditional Chinese medicine with the effects of clearing away heat, purging fire and dampness, detoxification and detumescence. Its main chemical constituents are flavonoids and alkaloids, which have many pharmacological effects, such as immunosuppressive, hypoglycemic and lowering blood pressure. In this paper, the chemical composition and pharmacological effects of cypress are reviewed in order to provide the references for further research and development of cypress.

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Reference (29)

[1]	朱志明,赖潇潇, 苏慕霞.不同产地黄柏及关黄柏有效成分的含量测定[J].临床医学工程,2011,18(1):106-108.
[2]	闫玉鑫.川黄柏的抗肿瘤化学成分研究[J].云南师范大学学报(自然科学版),2015,35(3):75-78.
[3]	汤欢,向丽,赵莎,等.应用DNA条形码ITS2序列对市售药材黄柏的鉴定研究[J].世界科学技术-中医药现代化,2016,18(2):184-190.
[4]	WANG H,YAN G,ZHANG A,et al.Rapid discovery and global characterization of chemical constituents and rats metabolites of Phellodendri amurensis cortex by ultra-performance liquid chromatography-eleetrospray ionization/quadrupole-time-of-flight mass spectrometry coupled with pattern recognition approach[J].Analyst,2013,138(11):3303-3312.
[5]	WANG H,SUN H,ZHANG A,et al.Rapid identification and comparative analysis of the chemical constituents and metabolites of Phellodendri amurensis cortex and Zhibai Dihuang pill by uhra-performance liquid chromatography with quadrupole TOF-MS[J].J Sep Sci,2013,36(24):3874-3882.
[6]	LEE SH,KWAK SC,KIM DK,et al.Effects of Huang Bai(Phellodendri Cortex)and three other herbs on GnRH and GH levels in GTl-7 and GH3 cells[J].Evid Based Complement Alternat Med,2016,2016:9389028.
[7]	WANG W,ZU Y,FU Y,et al.In vitro antioxidant,antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr.from China[J].Am J Chin Med,2009,37(1):195-203.
[8]	SWANSON GP,JONES WE 3rd,HA CS,et al.Tolerance of Phellodendron amurense bark extract(Nexrutine) in patients with human prostate cancer[J]. Phytother Res,2015,29(1):40-42.
[9]	SUN H,WANG H,ZHANG A,et al.Chemical discrimination of cortex Phellodendri amurensis and cortex Phellodendri chinensis by multivariate analysis approach[J]. Pharmacogn Mag,2016,12(45):41-49.
[10]	藤田穆,和田桂二.黄柏成分(第一报)[J].药学杂志(日),1931,51(6):5061.
[11]	秦民坚,王衡奇.黄皮树树皮的化学成分研究[J].林产化学与工业,2003,23(4):42-46.
[12]	中华本草编委会.中华本草(精选本·上册)[M].上海:上海科学技术出版社,1998:10421.
[13]	张少君,罗时旋, 赵稷,等.关黄柏中总黄酮的提取工艺及抗氧化活性研究[J]. 黑龙江医药科学, 2015,38(3):11-13.
[14]	曾一,回瑞华,侯冬岩.黄柏中黄酮类化合物的提取及其抗氧化性分析[J]. 鞍山师范学院学报,2010, 12(6):60-62.
[15]	王本祥.现代中药药理与临床[M].天津:天津科学技术出版社, 2004:1385.
[16]	李跃辉,胡薏冰,王银,等.不同产区与采收期黄柏中小檗碱与黄柏碱含量对比研究[J].中国医药导报,2014,11(11):91-93.
[17]	陶晓倩,胡玉梅,王俨如,等. 39个中药材提取物对Aβ25-35诱导SH-SY5Y细胞损伤的保护作用筛选研究[J].世界科学技术(中医药现代化),2015,17(1):61-65.
[18]	廉莲,贾天柱.黄柏及其炮制品的抗痛风作用研究[J].安徽农业科学,2011,39(15):8911-8912+8932.
[19]	刘睿,胡家才.黄柏对尿酸性肾病大鼠的影响及机制[J].武汉大学学报(医学版),2011,32(2):180-182.
[20]	王君明,崔瑛,申玲玲,等.中药致药源性肝损伤的氧化应激机制研究进展[J].中国实验方剂学杂志,2011,17(5):247-249.
[21]	王秋红,杨欣,王蒙,等.黄芩与黄柏协同保护黄药子致肝毒性的实验研究[J].中国中药杂志,2016,41(5):898-903.
[22]	宋智琦,林熙然.中药黄柏、茯苓及栀子抗迟发型超敏反应作用的实验研究[J].中国皮肤性病学杂志,1997,11(3):143-144.
[23]	孔令东,杨澄,仇熙,等.黄柏炮制品清除氧自由基和抗脂质过氧化作用[J].中国中药杂志,2001,26(4):245-248.
[24]	毛燕欣,庄洁, 赵志刚.黄柏在皮肤科的临床应用与药理研究[J].中国中医药现代远程教育,2007,5(5):34-37.
[25]	SUN H,WANG H,ZHANG A,et al.Berberine ameliorates nonbacterial prostatitis via multi-target metabolic network regulation[J].OMICS,2015,19(3):186-195.
[26]	WANG W,LI Q,LIU Y,et al.Ionic liquid-aqueous solution ultrasonic-assisted extraction of three kinds of alkaloids from Phellodendron amurense Rupr and optimize conditions use response surface[J].Ultrason Sonochem,2015,24:13-18.
[27]	MOHAN V,AGARWAL R,SINGH RP.A novel alkaloid,evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells[J].Biochem Biophys Res Commun,2016,477(4):1065-1071.
[28]	BRIBI N,ALGIERI F, RODRIGUEZ-NOGALES A,et al.Intestinal anti-inflammatory effects of total alkaloid extract from Fumaria capreolata in the DNBS model of mice colitis and intestinal epithelial CMT93 cells[J].Phytomedicine,2016,23(9):901-913.
[29]	孙晖,李先娜,张颖,等.利用血液代谢组学研究关黄柏生物碱对慢性非细菌性前列腺炎模型大鼠的干预作用[J].世界科学技术(中医药现代化),2016,18(10):1709-1719.

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Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects

doi: 10.3969/j.issn.1006-0111.2018.05.002

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通讯作者: 陈斌, bchen63@163.com

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Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects

doi: 10.3969/j.issn.1006-0111.2018.05.002

1. Shanghai TCM-Integrated Hospital, Shanghai TCM-Integrated Research Institute of pulse tube disease, Shanghai 200082, China

2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects

doi: 10.3969/j.issn.1006-0111.2018.05.002

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views

Research progress of Cortex Phellodendri in the chemical constituents and their pharmacological effects

doi: 10.3969/j.issn.1006-0111.2018.05.002

1. Shanghai TCM-Integrated Hospital, Shanghai TCM-Integrated Research Institute of pulse tube disease, Shanghai 200082, China 2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

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1. Shanghai TCM-Integrated Hospital, Shanghai TCM-Integrated Research Institute of pulse tube disease, Shanghai 200082, China

2. Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China