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Volume 36 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(4): 329-333,354

LIU Xiaoling, CAI Xiaohui, NI Xiaoxia, WANG Qingfen, CHEN Jinshan. Optimization on alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 329-333,354. doi: 10.3969/j.issn.1006-0111.2018.04.009
Citation: LIU Xiaoling, CAI Xiaohui, NI Xiaoxia, WANG Qingfen, CHEN Jinshan. Optimization on alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 329-333,354. doi: 10.3969/j.issn.1006-0111.2018.04.009
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Optimization on alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method

doi: 10.3969/j.issn.1006-0111.2018.04.009

  • The 175 th Hospital of PLA, Zhangzhou 363000, China

  • Received Date: 2017-12-03
  • Rev Recd Date: 2018-05-14
  • Objective To optimize the alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method. Methods With the transfer rates of geniposide and solid removal rate as comprehensive evaluation index, the effects of relative density, alcohol concentration, stirring speed and standing time were investigated by the single factor experiment on the alcohol precipitation process. By analysis of variance, the key factors that could influence the alcohol precipitation process were determined. Then the range of parameters of key factors was further studied and explored by central composite design-response surface method. Results The optimum preparation conditions were as follows:the relative density was 1.07, alcohol concentration was 84%,standing time was 8 h,stirring speed was 1762 r/min. Conclusion The alcohol precipitation process of compound Yinchen mixture could be optimized by the response surface method, which could help to enhance the stability of the process.
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    [2] 曹锦花. 茵陈的化学成分和药理作用研究进展[J]. 沈阳药科大学学报,2013,30(6):489-494.
    [3] 邬博,刘彦晶,连丽. 大黄的药理作用研究进展[J]. 中国中医药现代远程教育,2015,20(13):152-154.
    [4] 杨全军,范明松,孙兆林,等. 栀子化学成分、药理作用及体内过程研究进展[J]. 中国现代中药,2010,9(12):7-12.
    [5] 王恩力,董方,姚景春. 栀子苷药理学和毒理学研究进展[J]. 中国药房,2015,19(26):2730-2733.
    [6] 窦志华,陈智娴,王冬梅,等.茵陈蒿汤醇提与水提部位利胆保肝药效研究[J].中国中医药信息杂志,2012,9(19):40-42.
    [7] 蔡华丹,张慧芹,续畅,等. 茵陈蒿汤水提物和醇提物活性组分的差异及对D-GaLN诱导大鼠急性肝损伤预防作用的比较[J]. 中国实验方剂学杂志,2013,10(19):216-220.
    [8] 窦志华,罗琳,侯金燕,等. 茵陈蒿汤保肝退黄药效部位筛选[J]. 时珍国医国药,2014,25(10):2371-2373.
    [9] 史亚军,王昌利,赵海峰,等. 星点设计-效应面法优选止鼾颗粒成型工艺[J].中成药,2014,9(36):1863-1866.
    [10] 王永香,米慧娟,张传力,等. Box-Behnken响应面法优化热毒宁注射液金银花和青蒿(金青)的醇沉工艺研究[J]. 中草药,5(46):671-678.
    [11] 李喜香,刘效栓,刘维忠,等. 姜石肠炎康颗粒醇沉工艺的星点设计-效应面法优化[J]. 时珍国医国药,2016,8(27):1887-1891.
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Optimization on alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method

doi: 10.3969/j.issn.1006-0111.2018.04.009
  • The 175 th Hospital of PLA, Zhangzhou 363000, China
  • Received Date: 2017-12-03
  • Rev Recd Date: 2018-05-14

Abstract: Objective To optimize the alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method. Methods With the transfer rates of geniposide and solid removal rate as comprehensive evaluation index, the effects of relative density, alcohol concentration, stirring speed and standing time were investigated by the single factor experiment on the alcohol precipitation process. By analysis of variance, the key factors that could influence the alcohol precipitation process were determined. Then the range of parameters of key factors was further studied and explored by central composite design-response surface method. Results The optimum preparation conditions were as follows:the relative density was 1.07, alcohol concentration was 84%,standing time was 8 h,stirring speed was 1762 r/min. Conclusion The alcohol precipitation process of compound Yinchen mixture could be optimized by the response surface method, which could help to enhance the stability of the process.

LIU Xiaoling, CAI Xiaohui, NI Xiaoxia, WANG Qingfen, CHEN Jinshan. Optimization on alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 329-333,354. doi: 10.3969/j.issn.1006-0111.2018.04.009
Citation: LIU Xiaoling, CAI Xiaohui, NI Xiaoxia, WANG Qingfen, CHEN Jinshan. Optimization on alcohol precipitation process of compound Yinchen mixture by central composite design-response surface method[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 329-333,354. doi: 10.3969/j.issn.1006-0111.2018.04.009
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