Research progress of dexmedetomidine in nerve block

CHEN Qi; LIU Xing; LIU Hongliang

doi:10.3969/j.issn.1006-0111.2018.04.001

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2018 > 36(4): 289-292

CHEN Qi, LIU Xing, LIU Hongliang. Research progress of dexmedetomidine in nerve block[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001

Citation:

CHEN Qi, LIU Xing, LIU Hongliang. Research progress of dexmedetomidine in nerve block[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 289-292. doi: 10.3969/j.issn.1006-0111.2018.04.001

Research progress of dexmedetomidine in nerve block

doi: 10.3969/j.issn.1006-0111.2018.04.001

Chongqing University Affiliated Cancer Hospital/Chongqing Cancer Institue/Chongqing Cancer Hospital, Chongqing 400030, China

Received Date: 2017-06-20
Rev Recd Date: 2018-01-20

Abstract

Dexmedetomidine(Dex) is a specific alpha-2-adrenergic agonist which was widely used in nerve blocks as an adjuvant to local anesthetic(LA) in order to shortening the onset time, prolonging the analgesic effect and reducing the postoperative analgesic consumption.When compared with other adjuvant to LA,Dex was effective in providing better analgesia efficacy with fewer side effects.
- dexmedetomidine,
- nerve block,
- safety,
- mechanism

References

[1]	DON SEBASTIAN, RAVI M, DINESH K. Comparison of dexmedetomidine and clonidine an adjuvant to ropivacaine in supraclavicular brachial plexus nerve blocks[J]. Journal of dental and medical science,2015,14(3):2279-2861.
[2]	GERTLER R, BROWN HC, MITCHELL DH, et al. Dexmedetomidine:a novel sedative-analgesic agent[J]. Proc. (Bayl Univ Med Cent), 2001, 14(1):13-21.
[3]	TALKE P, RICHARDSON CA, SCHEININ M, et al. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine[J]. Anesth Analg,1997; 85(5):1136-1142.
[4]	TAIJI K. Dexmedetomidine hydrochloride (Precedex), a new sedative in intensive care, its pharmacological characteristics and clinical study result[J]. Nippon Yakurigaku Zasshi,2004,124(3):171-179.
[5]	DUKA I, GAVRAS I, JOHNS C,et al. Role of the postsynaptic alpha(2)-adrenergic receptor subtypes in catecholamine-induced vasoconstriction[J]. Gen Pharmacol,2000,34(2):101-106.
[6]	TURAN A,MEMIS D,KAYA G, et al. The prevention of pain from injection of propofol by dexmedetomidine and comparison with lidocaine[J].Can J Anaesth,2005,52(5):548-549.
[7]	AGARWAL S, AGGARWAL R, GUPTA P. Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block[J].Anaesthesiol Clin Pharmacol,2014, 30(1):36-40.
[8]	DAR FA, NAJAR MR, JAN N.Dexmedetomidine Added to Ropivacaine Prolongs Axillary Brachial Plexus Block[J].International Journal of Biomedical and Advance Research,2013, 4(10):719-722.
[9]	ZHANG Y, WANG CS, SHI JH, et al. Perineural administration of dexmedetomidine in combination with ropivacaine prolongs axillary brachial plexus block[J]. Int J Clin Exp Med,2014; 7(3):680-685.
[10]	BHARTI N, SARDANA DK, BALA I. The analgesic efficacy of dexmedetomidine as an adjunct to local anesthetics in supraclavicular brachial plexus block:a randomized controlled trial[J]. Anesth Analg,2015,121(6):1655-1660.
[11]	ABDALLAH FW,BRULL R. Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block:a systematic review and meta-analysis[J]. Br J Anaesth,2013,110(6):915-925.
[12]	RANCOURT MP,ALBERT NT,CÔTÉM,et al. Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine[J]. Anesth Analg,2012,115(4):958-962.
[13]	ABDULATIF M, FAWZY M, NASSAR H,et al. The effects of perineural dexmedetomidine on the pharmacodynamic profile of femoral nerve block:a dose-finding randomised, controlled, double-blind study[J]. Anaesthesia,2016;71(10):1177-1185.
[14]	HELAL SM, ESKANDR AM, GABALLAH KM,et al. Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block[J]. Saudi J Anaesth,2016; 10(1):18-24.
[15]	LUNDBLAD M, MARHOFER D, EKSBORG S, et al. Dexmedetomidine as adjunct to ilioinguinal/iliohypogastric nerve blocks for pediatric inguinal hernia repair:an exploratory randomized controlled trial[J]. Paediatr Anaesth,2015, 25(9):897-905.
[16]	ALMARAKBI WA, KAKI AM.Addition of dexmedetomidine to bupivacaine in transversus abdominis plane block potentiates post-operative pain relief among abdominal hysterectomy patients:A prospective randomized controlled trial[J]. Saudi J Anaesth,2014,8(2):161-166.
[17]	KIVIST KT, KALLIO A, NEUVONEN PJ.Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine[J]. Eur J Clin Pharmacol,1994;46(4):345-349.
[18]	BRUMMETT CM, NORAT MA,PALMISANO JM,et al. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat[J].Anesthesiology,2008; 109(3):502-511.
[19]	KONAKCI S,ADANIR T,YILMAZ G,et al. The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route[J]. Eur J Anaesthesiol,2008,25(5):403-409.
[20]	ANDERSEN JH, GREVSTAD U, SIEGEL H,et al. Does dexmedetomidine have a perineural mechanism of action when used as an adjuvant to ropivacaine? A paired, blinded, randomized trial in healthy volunteers[J].Anesthesiology,2017;126(1):66-73.
[21]	HARSHAVARDHANA HS.Efficacy of dexmedetomidine compared to clonidine added to ropivacaine in supraclavicular nerve blocks:A prospective, randomized, double blind study[J]. Int J Med Health Sci,2014,(3);127-133.
[22]	SWAMI SS, KENIYA VM, LADI SD,et al. Comparison of dexmedetomidine and clonidine (a2 agonist drugs) as an adjuvant to local anaesthesia in supraclavicular brachial plexus block:A randomised double-blind prospective study[J]. Indian J Anaesth,2012,56(3):243-249.
[23]	SONG JH,SHIM HY,LEE TJ,et al. Comparison of dexmedetomidine and epinephrine as an adjuvant to 1% mepivacaine in brachial plexus block[J]. Korean J Anesthesiol,2014,66(4):283-289.
[24]	MAHENDRU V,TEWARI A,KATYAL S,et al. A comparison of intrathecal dexmedetomidine,clonidine,and fentanyl as adjuvants to hyperbaric bupivacaine for lower limb surgery:A double blind controlled study[J]. J Anaesthesiol Clin Pharmacol,2013,29(4):496-502.
[25]	STARKE K,WAGNER J,SCHVMANN HJ. Adrenergic neuron blockade by clonidine:comparison with guanethidine and local anesthetics[J]. Arch Int Pharmacodyn Ther,1972,195(2):291-308.
[26]	BRUMMETT CM,HONG EK,JANDA AM,et al. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current[J]. Anesthesiology,2011,115(4):836-843.
[27]	BUTTERWORTH JF 5TH,STRICHARTZ GR. The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers[J]. Anesth Analg,1993,76(2):295-301.
[28]	YOSHITOMI T,KOHJITANI A,MAEDA S,et al. Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor[J]. Anesth Analg,2008,107(1):96-101.
[29]	李金玉,葛东建,祁宾,等. 不同剂量右美托咪定混合罗哌卡因用于臂丛神经阻滞的效果[J]. 中华麻醉学杂志,2013,33(6):711-713.
[30]	MARHOFER P, BRUMMETT CM. Safety and efficiency of dexmedetomidine as adjuvant to local anesthetics[J]. Curr Opin Anaesthesiol,2016;29(5):632-637.

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通讯作者: 陈斌, bchen63@163.com

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Research progress of dexmedetomidine in nerve block

Chongqing University Affiliated Cancer Hospital/Chongqing Cancer Institue/Chongqing Cancer Hospital, Chongqing 400030, China

Received Date: 2017-06-20

Rev Recd Date: 2018-01-20

Key words:

Abstract: Dexmedetomidine(Dex) is a specific alpha-2-adrenergic agonist which was widely used in nerve blocks as an adjuvant to local anesthetic(LA) in order to shortening the onset time, prolonging the analgesic effect and reducing the postoperative analgesic consumption.When compared with other adjuvant to LA,Dex was effective in providing better analgesia efficacy with fewer side effects.

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Reference (30)

[1]	DON SEBASTIAN, RAVI M, DINESH K. Comparison of dexmedetomidine and clonidine an adjuvant to ropivacaine in supraclavicular brachial plexus nerve blocks[J]. Journal of dental and medical science,2015,14(3):2279-2861.
[2]	GERTLER R, BROWN HC, MITCHELL DH, et al. Dexmedetomidine:a novel sedative-analgesic agent[J]. Proc. (Bayl Univ Med Cent), 2001, 14(1):13-21.
[3]	TALKE P, RICHARDSON CA, SCHEININ M, et al. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine[J]. Anesth Analg,1997; 85(5):1136-1142.
[4]	TAIJI K. Dexmedetomidine hydrochloride (Precedex), a new sedative in intensive care, its pharmacological characteristics and clinical study result[J]. Nippon Yakurigaku Zasshi,2004,124(3):171-179.
[5]	DUKA I, GAVRAS I, JOHNS C,et al. Role of the postsynaptic alpha(2)-adrenergic receptor subtypes in catecholamine-induced vasoconstriction[J]. Gen Pharmacol,2000,34(2):101-106.
[6]	TURAN A,MEMIS D,KAYA G, et al. The prevention of pain from injection of propofol by dexmedetomidine and comparison with lidocaine[J].Can J Anaesth,2005,52(5):548-549.
[7]	AGARWAL S, AGGARWAL R, GUPTA P. Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block[J].Anaesthesiol Clin Pharmacol,2014, 30(1):36-40.
[8]	DAR FA, NAJAR MR, JAN N.Dexmedetomidine Added to Ropivacaine Prolongs Axillary Brachial Plexus Block[J].International Journal of Biomedical and Advance Research,2013, 4(10):719-722.
[9]	ZHANG Y, WANG CS, SHI JH, et al. Perineural administration of dexmedetomidine in combination with ropivacaine prolongs axillary brachial plexus block[J]. Int J Clin Exp Med,2014; 7(3):680-685.
[10]	BHARTI N, SARDANA DK, BALA I. The analgesic efficacy of dexmedetomidine as an adjunct to local anesthetics in supraclavicular brachial plexus block:a randomized controlled trial[J]. Anesth Analg,2015,121(6):1655-1660.
[11]	ABDALLAH FW,BRULL R. Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block:a systematic review and meta-analysis[J]. Br J Anaesth,2013,110(6):915-925.
[12]	RANCOURT MP,ALBERT NT,CÔTÉM,et al. Posterior tibial nerve sensory blockade duration prolonged by adding dexmedetomidine to ropivacaine[J]. Anesth Analg,2012,115(4):958-962.
[13]	ABDULATIF M, FAWZY M, NASSAR H,et al. The effects of perineural dexmedetomidine on the pharmacodynamic profile of femoral nerve block:a dose-finding randomised, controlled, double-blind study[J]. Anaesthesia,2016;71(10):1177-1185.
[14]	HELAL SM, ESKANDR AM, GABALLAH KM,et al. Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block[J]. Saudi J Anaesth,2016; 10(1):18-24.
[15]	LUNDBLAD M, MARHOFER D, EKSBORG S, et al. Dexmedetomidine as adjunct to ilioinguinal/iliohypogastric nerve blocks for pediatric inguinal hernia repair:an exploratory randomized controlled trial[J]. Paediatr Anaesth,2015, 25(9):897-905.
[16]	ALMARAKBI WA, KAKI AM.Addition of dexmedetomidine to bupivacaine in transversus abdominis plane block potentiates post-operative pain relief among abdominal hysterectomy patients:A prospective randomized controlled trial[J]. Saudi J Anaesth,2014,8(2):161-166.
[17]	KIVIST KT, KALLIO A, NEUVONEN PJ.Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine[J]. Eur J Clin Pharmacol,1994;46(4):345-349.
[18]	BRUMMETT CM, NORAT MA,PALMISANO JM,et al. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat[J].Anesthesiology,2008; 109(3):502-511.
[19]	KONAKCI S,ADANIR T,YILMAZ G,et al. The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route[J]. Eur J Anaesthesiol,2008,25(5):403-409.
[20]	ANDERSEN JH, GREVSTAD U, SIEGEL H,et al. Does dexmedetomidine have a perineural mechanism of action when used as an adjuvant to ropivacaine? A paired, blinded, randomized trial in healthy volunteers[J].Anesthesiology,2017;126(1):66-73.
[21]	HARSHAVARDHANA HS.Efficacy of dexmedetomidine compared to clonidine added to ropivacaine in supraclavicular nerve blocks:A prospective, randomized, double blind study[J]. Int J Med Health Sci,2014,(3);127-133.
[22]	SWAMI SS, KENIYA VM, LADI SD,et al. Comparison of dexmedetomidine and clonidine (a2 agonist drugs) as an adjuvant to local anaesthesia in supraclavicular brachial plexus block:A randomised double-blind prospective study[J]. Indian J Anaesth,2012,56(3):243-249.
[23]	SONG JH,SHIM HY,LEE TJ,et al. Comparison of dexmedetomidine and epinephrine as an adjuvant to 1% mepivacaine in brachial plexus block[J]. Korean J Anesthesiol,2014,66(4):283-289.
[24]	MAHENDRU V,TEWARI A,KATYAL S,et al. A comparison of intrathecal dexmedetomidine,clonidine,and fentanyl as adjuvants to hyperbaric bupivacaine for lower limb surgery:A double blind controlled study[J]. J Anaesthesiol Clin Pharmacol,2013,29(4):496-502.
[25]	STARKE K,WAGNER J,SCHVMANN HJ. Adrenergic neuron blockade by clonidine:comparison with guanethidine and local anesthetics[J]. Arch Int Pharmacodyn Ther,1972,195(2):291-308.
[26]	BRUMMETT CM,HONG EK,JANDA AM,et al. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current[J]. Anesthesiology,2011,115(4):836-843.
[27]	BUTTERWORTH JF 5TH,STRICHARTZ GR. The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers[J]. Anesth Analg,1993,76(2):295-301.
[28]	YOSHITOMI T,KOHJITANI A,MAEDA S,et al. Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor[J]. Anesth Analg,2008,107(1):96-101.
[29]	李金玉,葛东建,祁宾,等. 不同剂量右美托咪定混合罗哌卡因用于臂丛神经阻滞的效果[J]. 中华麻醉学杂志,2013,33(6):711-713.
[30]	MARHOFER P, BRUMMETT CM. Safety and efficiency of dexmedetomidine as adjuvant to local anesthetics[J]. Curr Opin Anaesthesiol,2016;29(5):632-637.

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Research progress of dexmedetomidine in nerve block

doi: 10.3969/j.issn.1006-0111.2018.04.001

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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