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Volume 36 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(2): 136-139,146

ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
Citation: ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
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Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion

doi: 10.3969/j.issn.1006-0111.2018.02.009

  • Department of Pharmacy, Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University, Urumqi 830054, China

  • Received Date: 2017-06-30
  • Rev Recd Date: 2017-09-28
  • Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion. Methods The databases of EMBASE, PUBMED, the Cochrane Register of Controlled Trials, CBM, CNKI and WanFang were searched. The Cochrane Revman5.2 software was used for Meta-analysis. Results Two RCTs and eight observational studies were included in the systematic literature search with total of 1 764 patients. 1 037 patients received vancomycin with continuous infusion while 727 patients with intermittent infusion. The Meta-analysis indicated that there was no significant difference in renal toxicity between continuous infusion group and intermittent infusion group(P>0.05). Conclusion Vancomycin continuous infusion cannot effectively reduce the incidence of renal toxicity.
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    [2] Liu C,Bayer A,Cosgrove S E,et al.Clinical practice guidelines by the infectious diseases society of America for the treatment of Methicillin-Resistant Staphylococcus aureus infections in adults and children:executive summary[J].Clin Infect Dis,2011,52(3):285-292.
    [3] 耐甲氧西林金黄色葡萄球菌感染防治专家委员会.耐甲氧西林金黄色葡萄球菌感染防治专家共识[J].中华实验和临床感染病杂志(电子版),2010,4(2):215-223.
    [4] 陈春辉,李光辉.美国感染病学会治疗成人及儿童甲氧西林耐药金黄色葡萄球菌感染临床实践指南[J].中国感染与化疗杂志,2011,11(6):428-435.
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    [7] 黄榜江,肖政,汪成琼,等.我国慢性阻塞性肺病院内真菌感染特征及高危药物因素的Meta分析[J].实用医学杂志,2015,31(1):110-115.
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    [10] 陈耀龙,李晓,梅又文,等.循证医学术语介绍V[J].中国循证医学杂志,2009,9(7):734-739.
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Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion

doi: 10.3969/j.issn.1006-0111.2018.02.009
  • Department of Pharmacy, Traditional Chinese Medical Hospital Affiliated to Xinjiang Medical University, Urumqi 830054, China
  • Received Date: 2017-06-30
  • Rev Recd Date: 2017-09-28

Abstract: Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion. Methods The databases of EMBASE, PUBMED, the Cochrane Register of Controlled Trials, CBM, CNKI and WanFang were searched. The Cochrane Revman5.2 software was used for Meta-analysis. Results Two RCTs and eight observational studies were included in the systematic literature search with total of 1 764 patients. 1 037 patients received vancomycin with continuous infusion while 727 patients with intermittent infusion. The Meta-analysis indicated that there was no significant difference in renal toxicity between continuous infusion group and intermittent infusion group(P>0.05). Conclusion Vancomycin continuous infusion cannot effectively reduce the incidence of renal toxicity.

ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
Citation: ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
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