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Volume 36 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(2): 121-125

SUN Lili, CHEN Zhenyi, QIN Chunxia, HU Xiang, FANG Bangjiang, LI Tiejun. Study on extraction technology of Fuyuan Xingnao granule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 121-125. doi: 10.3969/j.issn.1006-0111.2018.02.006
Citation: SUN Lili, CHEN Zhenyi, QIN Chunxia, HU Xiang, FANG Bangjiang, LI Tiejun. Study on extraction technology of Fuyuan Xingnao granule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 121-125. doi: 10.3969/j.issn.1006-0111.2018.02.006
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Study on extraction technology of Fuyuan Xingnao granule

doi: 10.3969/j.issn.1006-0111.2018.02.006
  • 1.

    Department of Pharmacy, Punan Hospital of Pudong New Area, Shanghai 200125, China

  • 2.

    Longhua Hospital Affliated to Shanghai Traditional Chinese Medicine University, Shanghai 200032, China

  • 3.

    Shanghai Zhongsheng Pharmaceutical Technology Co., Ltd., Shanghai 200125, China

  • Received Date: 2017-02-19
  • Rev Recd Date: 2017-05-19
  • Objective To study the extraction technology and optimize the extraction process of Fuyuan Xingnao granule. Methods The preliminary extraction process was designed by routine extraction method combined with the results of pharmacological activity experiment. The extraction process was optimized with orthogonal test. Results The extract was obtained by ethanol reflux extraction, water decoction extraction or ethanol precipitation followed by filtration and concentration. The optimal process for ethanol reflux extraction was extracting twice with 50% ethanol. The ratio of liquor to dry material was 8:1 for the first time and 6:1 for the second time. The extraction time was 120 minutes for the first time and 80 minutes for the second time. The optimal process for water decoction extraction was extracting twice with 120 minutes and 80 minutes each time. The ratio of liquor to dry material was 10:1 for the first time and 8:1 for the second time. The extraction temperature was100℃. The best ethanol precipitation process was 16 hour extraction with 80% ethanol. The ratio of ethanol to dry material was 2:1. Conclusion The quality of Fuyuan Xingnao granule extract with this optimized extraction process was in line with requirements of Pharmacopoeia of the People's Republic of China 2015, 4 Volumes(0104 granule).
  • [1] 耿贇, 方邦江, 马智慧, 等. 复元醒脑汤治疗急性缺血性中风的临床研究[J]. 中国中医急症,2014,23(11):1970-1972.
    [2] 王耀文,孟宪生,包永睿,等.人参提取工艺的优化及其有效成分与药效学相关性分析[J].中成药,2012,34(11):2240-2242.
    [3] 于栋华,张颖,徐红英,等.水蛭水煎醇沉工艺的正交设计研究[J].中医药信息,2011,28(6):75-76.
    [4] 王帅,包永睿,杨欣欣,等.中药东北天南星生物碱类成分提取纯化工艺研究[J].时珍国医国药,2015,26(10):2343-2345.
    [5] 吕洁,李晓燕,李向军,等.大黄中结合蒽醌的提取工艺研究[J].河北中医药学报,2009,24(4):34-35.
    [6] 瞿林海,郑明,楼宜嘉.三七总皂苷提取工艺研究[J].中药材,2006,29(6):593-595.
    [7] 刘安龙.中药单煎与共煎体会[J].河北中医,2006,28(7):531.
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Study on extraction technology of Fuyuan Xingnao granule

doi: 10.3969/j.issn.1006-0111.2018.02.006
  • 1. Department of Pharmacy, Punan Hospital of Pudong New Area, Shanghai 200125, China
  • 2. Longhua Hospital Affliated to Shanghai Traditional Chinese Medicine University, Shanghai 200032, China
  • 3. Shanghai Zhongsheng Pharmaceutical Technology Co., Ltd., Shanghai 200125, China
  • Received Date: 2017-02-19
  • Rev Recd Date: 2017-05-19

Abstract: Objective To study the extraction technology and optimize the extraction process of Fuyuan Xingnao granule. Methods The preliminary extraction process was designed by routine extraction method combined with the results of pharmacological activity experiment. The extraction process was optimized with orthogonal test. Results The extract was obtained by ethanol reflux extraction, water decoction extraction or ethanol precipitation followed by filtration and concentration. The optimal process for ethanol reflux extraction was extracting twice with 50% ethanol. The ratio of liquor to dry material was 8:1 for the first time and 6:1 for the second time. The extraction time was 120 minutes for the first time and 80 minutes for the second time. The optimal process for water decoction extraction was extracting twice with 120 minutes and 80 minutes each time. The ratio of liquor to dry material was 10:1 for the first time and 8:1 for the second time. The extraction temperature was100℃. The best ethanol precipitation process was 16 hour extraction with 80% ethanol. The ratio of ethanol to dry material was 2:1. Conclusion The quality of Fuyuan Xingnao granule extract with this optimized extraction process was in line with requirements of Pharmacopoeia of the People's Republic of China 2015, 4 Volumes(0104 granule).

SUN Lili, CHEN Zhenyi, QIN Chunxia, HU Xiang, FANG Bangjiang, LI Tiejun. Study on extraction technology of Fuyuan Xingnao granule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 121-125. doi: 10.3969/j.issn.1006-0111.2018.02.006
Citation: SUN Lili, CHEN Zhenyi, QIN Chunxia, HU Xiang, FANG Bangjiang, LI Tiejun. Study on extraction technology of Fuyuan Xingnao granule[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 121-125. doi: 10.3969/j.issn.1006-0111.2018.02.006
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