NIE Li, GE Weihong. Effect of leukotriene receptor antagonist on anti-inflammation and immune function in asthmatic patients[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 562-564,568. doi: 10.3969/j.issn.1006-0111.2017.06.020
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NIE Li, GE Weihong. Effect of leukotriene receptor antagonist on anti-inflammation and immune function in asthmatic patients[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 562-564,568. doi: 10.3969/j.issn.1006-0111.2017.06.020
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Effect of leukotriene receptor antagonist on anti-inflammation and immune function in asthmatic patients
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Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated to Medical College, Nanjing University, Nanjing 210008, China
- Received Date: 2017-06-15
- Rev Recd Date:
2017-10-23
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Abstract
Objective To analyze the effect of leukotriene receptor antagonist on anti-inflammation and immune function in asthmatic patients. Methods 86 cases of asthma patients in our hospital from August to December 2014 were taken as the research objects, they were randomly divided into the observation group with 43 cases and the control group with 43 cases, the control group was treated with conventional therapy plus Seretide, the observation group was given leukotriene receptor antagonist-montelukast based on the control group, two groups were treated for 14 d. The changes of inflammatory factors and immune function, therapeutic effect, adverse reaction were compared between the two groups after treatment. In the observation group after the treatment,the IL-6, TNF-α and CRP were lower than that in the control group, the difference was statistically significant (P<0.05). In the observation group after the treatment, CD4+ and CD4+/CD8+ were higher than that in the control group, CD8+ was lower than that in the control group, the difference was statistically significant (P<0.05). After the treatment in the observation group, the ACT score was higher than that in the control group, the total effective rate was higher than that in the control group, the difference was statistically significant (P<0.05). There was no obvious adverse reaction in the two groups. Conclusion Leukotriene antagonist (montelukast) could play an important role in improving the immune function and anti-inflammation in asthma patients, which might be an important mechanism to improve the therapeutic effect of asthma.
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References
|
[1]
|
Ali Assad N,Sood A.Leptin,adiponectin and pulmonary diseases[J].Biochimie,2012,94(10):2180-2189. |
|
[2]
|
Rubini A.Interleukin-6 and lung inflammation:evidence for a causative role in inducing respiratory system resistance increments[J].Inflamm Allergy Drug Targets,2013,12(5):315-321. |
|
[3]
|
马红梅,刘香莲.孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的作用分析[J].海南医学院学报,2015,21(3):350-352. |
|
[4]
|
林江涛,祝墡珠,王家骥,等.中国支气管哮喘防治指南(基层版)[J].中国实用内科杂志,2013,33(8):615-622. |
|
[5]
|
李爱华.舒利迭联合孟鲁司特钠治疗支气管哮喘的临床研究[J].中国现代医生,2013,51(16):67-68. |
|
[6]
|
邓俊,杨艳,梁宇佳,等.孟鲁司特对哮喘大鼠气道炎症的调控作用及其机制[J].山东医药,2016,56(24):34-36. |
|
[7]
|
姜增凯,贾萍,叶晓歌. 孟鲁司特钠联合沙美特罗替卡松粉吸入剂治疗支气管哮喘的临床疗效及其对炎性因子、肺功能、免疫功能的影响研究[J].实用心脑肺血管病杂志,2016,24(4):49-52. |
|
[8]
|
夏玉平,方圆.孟鲁司特钠联合阿奇霉素对支原体肺炎儿童免疫功能及肺功能的影响[J].海南医学院学报,2016,22(18):2115-2117. |
|
[9]
|
黄艳春,肖强.孟鲁司特钠对哮喘患儿免疫指标及促炎因子的影响[J].现代中西医结合杂志,2014,23(29):3252-3254. |
|
[10]
|
吴红样.孟鲁司特联合舒利迭对哮喘急性发作期患者疗效及免疫功能的影响[J].中国微生态学杂志,2015,27(5):568-570. |
|
[11]
|
孔黎明,孔金阁.舒利迭联合孟鲁司特对咳嗽变异性哮喘患儿的疗效及其对IL13、Ig E的影响[J].医学临床研究,2013,30(12):2353-2355. |
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