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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(6): 543-546

ZHONG Guixiang, YAN Jia, TANG Qiaoting, SONG Hongtao, ZHOU Xin. Study on quality standard of compound Heishen granules[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 543-546. doi: 10.3969/j.issn.1006-0111.2017.06.015
Citation: ZHONG Guixiang, YAN Jia, TANG Qiaoting, SONG Hongtao, ZHOU Xin. Study on quality standard of compound Heishen granules[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 543-546. doi: 10.3969/j.issn.1006-0111.2017.06.015
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Study on quality standard of compound Heishen granules

doi: 10.3969/j.issn.1006-0111.2017.06.015

  • Fuzhou General Hospital, Fuzhou 350025, China

  • Received Date: 2016-10-24
  • Rev Recd Date: 2017-03-16
  • Objective To establish a quality standard for compound Heishen granules. Methods Scrophulariae Radix and Belamcandae Rhizoma were identified by TLC.HPLC was used to determine the content of cinnamic acid,tectoridin and irisflorentin.The HPLC was performed on a column of Kromasil-C18(150 mm×4.6 mm,5 μm)with a mobile phase of acetonitrile(A)-0.1% hydrochloric acid(B)at a temperature 30℃. The detection wavelength was set at 270 nm and the flow rate at 1 ml/min. Results The TLC method had good specificity without interference from negative control.The calibration curve showed a good linear relationship within the range of 16.22-113.57 μg/ml for cinnamic acid(r=0.999 8),48.19-337.34 μg/ml for tectoridin(r=0.999 8)and 16.40-114.80 μg/ml for irisflorentin(r=0.999 9). The average recoveries were 99.23%,98.82%,99.17%. Conclusion The established method is rapid,accurate and reproducible. It can be used in the quality control of compound Heishen granules.
  • [1] 张传辉,陈小川,傅亚,等.建立并利用一测多评法优化玄参饮片润透工艺的研究[J].中医药现代化,2015,17(1):254-260.
    [2] 卞晓霞,罗跃娥,闫利华,等.一测多评法同步测定玄参药材中两种环烯醚萜类成分的含量[J].天津中医药大学学报,2014,33(2):98-100.
    [3] 赵昕,王沈歌,许志军,等.胃纳欣颗粒的质量标准研究[J].药学实践杂志,2016,34(2):167-170.
    [4] 国家药典委员会.中华人民共和国药典2015年版四部[S].北京:中国医药科技出版社,2015:374-377.
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Study on quality standard of compound Heishen granules

doi: 10.3969/j.issn.1006-0111.2017.06.015
  • Fuzhou General Hospital, Fuzhou 350025, China
  • Received Date: 2016-10-24
  • Rev Recd Date: 2017-03-16

Abstract: Objective To establish a quality standard for compound Heishen granules. Methods Scrophulariae Radix and Belamcandae Rhizoma were identified by TLC.HPLC was used to determine the content of cinnamic acid,tectoridin and irisflorentin.The HPLC was performed on a column of Kromasil-C18(150 mm×4.6 mm,5 μm)with a mobile phase of acetonitrile(A)-0.1% hydrochloric acid(B)at a temperature 30℃. The detection wavelength was set at 270 nm and the flow rate at 1 ml/min. Results The TLC method had good specificity without interference from negative control.The calibration curve showed a good linear relationship within the range of 16.22-113.57 μg/ml for cinnamic acid(r=0.999 8),48.19-337.34 μg/ml for tectoridin(r=0.999 8)and 16.40-114.80 μg/ml for irisflorentin(r=0.999 9). The average recoveries were 99.23%,98.82%,99.17%. Conclusion The established method is rapid,accurate and reproducible. It can be used in the quality control of compound Heishen granules.

ZHONG Guixiang, YAN Jia, TANG Qiaoting, SONG Hongtao, ZHOU Xin. Study on quality standard of compound Heishen granules[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 543-546. doi: 10.3969/j.issn.1006-0111.2017.06.015
Citation: ZHONG Guixiang, YAN Jia, TANG Qiaoting, SONG Hongtao, ZHOU Xin. Study on quality standard of compound Heishen granules[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 543-546. doi: 10.3969/j.issn.1006-0111.2017.06.015
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