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Volume 34 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(5): 455-458

SUN Huayan, XU Fenghua, LI Jie, BAI Lin, CAI Le. Study of optimization for the cream base of benzhydramine hydroehloride[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 455-458. doi: 10.3969/j.issn.1006-0111.2016.05.019
Citation: SUN Huayan, XU Fenghua, LI Jie, BAI Lin, CAI Le. Study of optimization for the cream base of benzhydramine hydroehloride[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 455-458. doi: 10.3969/j.issn.1006-0111.2016.05.019
shu

Study of optimization for the cream base of benzhydramine hydroehloride

doi: 10.3969/j.issn.1006-0111.2016.05.019
  • 1.

    General Hospital of PLA, Formulation Department, Beijing 100853, China

  • 2.

    General Hospital of PLA, Drug Quality Control Department, Beijing 100853, China

  • Received Date: 2015-09-07
  • Rev Recd Date: 2016-01-15
  • Objective To optimize the cream base of benzhydramine hydroehloride. Methods Five nonionic surfactants as an emulsifier were used to prepare benzhydramine hydroehloride creams. The five sorts of cream were evaluated from the appearance,preliminary stability, accelerated test stability and room temperature stability. Results Benzhydramine hydroehloride cream could be prepared using five nonionic surfactants. On appearance of smoothness, gloss and spread, formula E was best but formula A was worst, while formulas B and D were close and worse than formula E only. In the stability tests, all of creams had no obvious change after the centrifugal experiment and the low temperature experiment. In the high temperature experiment, the formula E was stable, formulas A, B and D showed a little appearance change, and the formula C became layered bleeding. In room temperature, the formula C became bleeding after five days, which happened to the formula A after one month, and formula B after two months. The formulas D and E had no obvious change until six months in room temperature. Conclusion The formulas D and E were stable, which had clinical application value.
  • [1] 中国人民解放军总后勤部卫生部. 中国人民解放军医疗机构制剂规范增补本[S].北京:人民军医出版社,2007:48.
    [2] 中华人民共和国卫生部药政局. 中国医院制剂规范[S].北京:中国医药科技出版社,1995:135-137.
    [3] 阚全程,雷正同.实用制剂注解[M].郑州: 河南医科大学出版社,1999: 346-347.
    [4] 苗 杰,王爱武,王楠楠,等. 不同基质配方对盐酸苯海拉明乳膏质量的影响[J]. 医药导报,2012,31(9):1207-1209.
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Study of optimization for the cream base of benzhydramine hydroehloride

doi: 10.3969/j.issn.1006-0111.2016.05.019
  • 1. General Hospital of PLA, Formulation Department, Beijing 100853, China
  • 2. General Hospital of PLA, Drug Quality Control Department, Beijing 100853, China
  • Received Date: 2015-09-07
  • Rev Recd Date: 2016-01-15

Abstract: Objective To optimize the cream base of benzhydramine hydroehloride. Methods Five nonionic surfactants as an emulsifier were used to prepare benzhydramine hydroehloride creams. The five sorts of cream were evaluated from the appearance,preliminary stability, accelerated test stability and room temperature stability. Results Benzhydramine hydroehloride cream could be prepared using five nonionic surfactants. On appearance of smoothness, gloss and spread, formula E was best but formula A was worst, while formulas B and D were close and worse than formula E only. In the stability tests, all of creams had no obvious change after the centrifugal experiment and the low temperature experiment. In the high temperature experiment, the formula E was stable, formulas A, B and D showed a little appearance change, and the formula C became layered bleeding. In room temperature, the formula C became bleeding after five days, which happened to the formula A after one month, and formula B after two months. The formulas D and E had no obvious change until six months in room temperature. Conclusion The formulas D and E were stable, which had clinical application value.

SUN Huayan, XU Fenghua, LI Jie, BAI Lin, CAI Le. Study of optimization for the cream base of benzhydramine hydroehloride[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 455-458. doi: 10.3969/j.issn.1006-0111.2016.05.019
Citation: SUN Huayan, XU Fenghua, LI Jie, BAI Lin, CAI Le. Study of optimization for the cream base of benzhydramine hydroehloride[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 455-458. doi: 10.3969/j.issn.1006-0111.2016.05.019
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