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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(4): 380-384

LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
Citation: LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
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A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy

doi: 10.3969/j.issn.1006-0111.2016.04.025
  • 1.

    Xuzhou Medical College, Xuzhou 221002, China

  • 2.

    The Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China

  • Received Date: 2015-11-16
  • Rev Recd Date: 2016-05-10
  • Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy. Methods Trials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12.0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment. Results Eight randomly controlled trials (n=1144) were included. Pooled Hp eradication rates were 85.91% and 69.21% for patients with and without Bifidobacterium viable triple capsule respectively, with the odds ratio (OR) being 3.07 (95% CI=2.25~4.19, test for overall effect Z=7.08, P<0.01); the occurrences of total adverse reactions were 7.58% and 20.87% respectively, with the summary OR being 0.42 (95% CI=0.29~0.61, test for overall effect Z=4.48, P<0.01). The difference of the two groups was statistically significant. Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treatment and improve adverse reactions during therapy.
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    [10] 钭慧敏. 双歧杆菌三联活菌胶囊联合三联疗法治疗幽门螺杆菌阳性消化性溃疡80例[J]. 中国药业, 2012, 21(23):49-50.
    [11] 檀心广, 米永刚, 杨杨. 培菲康对幽门螺杆菌感染慢性胃炎治疗的价值[J]. 海南医学, 2011, 22(19):25-26.
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    [13] 任珺, 郑京华, 魏虹. 培菲康联合四联疗法治疗难治性幽门螺杆菌感染54例疗效观察[J]. 海军医学杂志, 2013, 34(3):178-180.
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A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy

doi: 10.3969/j.issn.1006-0111.2016.04.025
  • 1. Xuzhou Medical College, Xuzhou 221002, China
  • 2. The Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
  • Received Date: 2015-11-16
  • Rev Recd Date: 2016-05-10

Abstract: Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy. Methods Trials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12.0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment. Results Eight randomly controlled trials (n=1144) were included. Pooled Hp eradication rates were 85.91% and 69.21% for patients with and without Bifidobacterium viable triple capsule respectively, with the odds ratio (OR) being 3.07 (95% CI=2.25~4.19, test for overall effect Z=7.08, P<0.01); the occurrences of total adverse reactions were 7.58% and 20.87% respectively, with the summary OR being 0.42 (95% CI=0.29~0.61, test for overall effect Z=4.48, P<0.01). The difference of the two groups was statistically significant. Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treatment and improve adverse reactions during therapy.

LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
Citation: LIU Liu, FEI Sujuan. A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter pylori eradication during clinical therapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(4): 380-384. doi: 10.3969/j.issn.1006-0111.2016.04.025
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