Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning

TAN Ning; LI Pengyue; DONG Boyu; ZHAO Mengdi; YANG Liu; LU Yang

doi:10.3969/j.issn.1006-0111.2016.04.016

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To study the rat pulmonary irritant of aerosol inhaled Tanreqing and Reduning injection. Methods Rats were devided into two groups for each medicine (low concentration group and high concentration group), nebulized drug administration for seven days, with the control group irrigated with saline, and were sacrificed. Through bronchoalveolar lavage, excurrent bronchoalveolar lavage fluid (BALF) was used for total protein determination and LDH vitality test to evaluate pulmonary toxicity of two medicines. Results The protein concentrations of two groups in low and high concentrations of Tanreqing and Reduning respectively are (193.78±27.74),(235.33±50.41) μg/ml;(174.02±17.82),(227.27±66.03) μg/ml;LDH vitalities respectively are 1065.21±181.76,1467.33±101.87;307.97±47.56,1377.29±566.48. By t-test, compared with normal saline, there was no significant effect among these five groups on protein concentration, but these two medicine were able to improve LDH activity (P<0.05) which was more obvious in high concentration group. When two medicines were in low concentration, LDH activity was higher in Tanreqing group with statistical significance (P<0.05). Conclusion Aerosol inhaled Tanreqing and Reduning injection in rats have some pulmonary irritation and potential safety hazard in this delivery way.

Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning

School of Chinese material medica, Beijing University of Chinese Medicine, Beijing 100029, China

Received Date: 2015-08-22

Rev Recd Date: 2016-01-03

Key words:

Abstract: Objective To study the rat pulmonary irritant of aerosol inhaled Tanreqing and Reduning injection. Methods Rats were devided into two groups for each medicine (low concentration group and high concentration group), nebulized drug administration for seven days, with the control group irrigated with saline, and were sacrificed. Through bronchoalveolar lavage, excurrent bronchoalveolar lavage fluid (BALF) was used for total protein determination and LDH vitality test to evaluate pulmonary toxicity of two medicines. Results The protein concentrations of two groups in low and high concentrations of Tanreqing and Reduning respectively are (193.78±27.74),(235.33±50.41) μg/ml;(174.02±17.82),(227.27±66.03) μg/ml;LDH vitalities respectively are 1065.21±181.76,1467.33±101.87;307.97±47.56,1377.29±566.48. By t-test, compared with normal saline, there was no significant effect among these five groups on protein concentration, but these two medicine were able to improve LDH activity (P<0.05) which was more obvious in high concentration group. When two medicines were in low concentration, LDH activity was higher in Tanreqing group with statistical significance (P<0.05). Conclusion Aerosol inhaled Tanreqing and Reduning injection in rats have some pulmonary irritation and potential safety hazard in this delivery way.

HTML

Reference (9)

[1]	凌祥,沈雁,孙春萌,等.肺部给药研究近况[J].药学研究,2014,33(12):711-714.
[2]	王淳,刘晓彬,权丽辉,等.中药肺部给药系统应用进展[J].世界科学技术:中医药现代化,2007,9(1):59-64.
[3]	雷卫平,吴英梅,林翠芬.痰热清注射液的临床应用[J].国际医药卫生导报,2005,11(14):110-113.
[4]	张妍,杨毅恒,刘芳,等.痰热清注射液雾化吸入治疗呼吸系统疾病的系统评价[J].中国医院用药评价与分析,2010,10(6):483-487.
[5]	唐韵.喜炎平注射液临床应用近况[J].世界临床药物,2014,35(3):184-188.
[6]	万珍,徐志锋,林俊明,等.喜炎平超声雾化吸入治疗成人急性上呼吸道感染疗效观察[J].新中医,2014,46(6):57-59.
[7]	张华静,郑德瑜.喜炎平注射液联合利巴韦林雾化吸入治疗小儿疱疹性咽峡炎观察[J].中医药临床杂志,2014,26(12):1247-1248.
[8]	王晶,任吉祥,谢雁鸣,等.喜炎平注射液治疗手足口病的系统评价[J].中国中药杂志,2013,38(18):3215-3222.
[9]	耿红,吴明杰.喜炎平雾化吸入后拍背吸痰佐治小儿毛细支气管炎的临床观察[J].临床合理用药杂志,2012,5(6B):70

Message Board

Study on the rat pulmonary irritation of aerosol inhaled Tanreqing and Reduning

doi: 10.3969/j.issn.1006-0111.2016.04.016

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views