Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 34 Issue 2
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(2): 138-141,166

FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
Citation: FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
shu

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

doi: 10.3969/j.issn.1006-0111.2016.02.011

  • No.425 Hospital of PLA, Sanya 572000, China

  • Received Date: 2015-08-11
  • Rev Recd Date: 2016-01-05
  • Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20, and high-performance liquid chromatography(HPLC). Structures were determined by spectroscopic analysis and comparison with reported data. Results Nine compounds were isolated. Their structures were determined as kalihinol E(1), kalihinol A(2), 10-epi-kalihinol X(3), 10-epi-kalihinol I(4), 1H-indole-3-carboxylic acid methyl ester(5), 1H-indole-3-carboxylic acid(6), 3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7), aristolone(8), and 5α, 8α-epidioxy-(22E, 24R)-erost-6, 22-dien-3β-ol(9). Conclusion Compounds 5 to 8 were isolated from the sponge of genus Acanthalla for the first time.
  • [1] 张书军,焦炳华. 世界海洋药物现状与发展趋势[J]. 中国海洋药物,2012,31(2):58-60.
    [2] Chang C W J,Patra A,Baker J A,et al. Kalihinols,multifunctional diterpenoid anntibiotics from marine sponges Acanthella spp[J]. J Am Chem Soc,1987,109(20):6119-6123.
    [3] Clark R J,Stapleton B L,Garson M J. New isocyano and isothiocyanato terpene metabolites from the tropical marine sponge Acanthella cavernosa[J]. Cheminform,2000,56(19):3071-3076.
    [4] Bugni T S,Singh M P,Chen L,et al. Kalihinols from two Acanthella cavernosa sponges:inhibitors of bacterial folate biosynthesis[J]. Tetrahedron,2004,60(33):6981-6988.
    [5] Fusetani N,Yasumuro K,Kawai H,et al. Kalihinene and isokalihinol B,Cytotoxic deterpene isonitriles from the marine sponge Acanthella klethra[J]. Tetrahedron Lett,1990,31(25):3559-3602.
    [6] Alvi K A,Tenenbaum L,Crews P. Anthelmintic polyfunctional nitrogen-containing terpenoids from marine sponges[J]. J Nat Prod,1991,54(1):71-78.
    [7] Miyaoka H,Shimomura M,Kimura H,et al. Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge,Acanthella sp[J]. Tetrahedron,1998,54(44):13467-13474.
    [8] Okino T,Yoshimura E,Hirota H,et al. Antifouling kalihinenes from the marine sponge Acanthella cavernosa[J]. Tetrahedron Lett,1995,36(47):8637-8640.
    [9] Hirota H,Tomono Y,Fusetani N. Terpenoids with antifouling activity against barnacle larvae from the marine sponge Acanthella cavernosa[J]. Tetrahedron,1996,52(7):2359-2368.
    [10] Okino T,Yoshimura E,Hirota H,et al. New antifouling kalihipyrans from the marine sponge Acanthella cavernosa[J]. J Nat Prod,1996,59(11):1081-1083.
    [11] Xu Y,Li N,Jiao WH,et al. Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa[J]. Tetrahedron,2012,68(13):2876-2883.
    [12] Xu Y,Lang JH,Jiao WH,et al. Formamido-diterpenes from the South China Sea Sponge Acanthella cavernosa. Marine drugs,2012,10(12):1445-1458.
    [13] Sun JZ,Chen KS,Yao LG,et al. A new kalihinol diterpene from the Hainan sponge Acanthella sp[J]. Arch Pharm Res,2009,32(11):1581-1584.
    [14] Yan XH,Zhu XZ,Yu JL,et al. 3-Oxo-axisonitrile-3,a new sesquiterpene isocyanide from the Chinese marine sponge Acanthella sp[J]. J Asian Nat Prod Res,2006,8(6):579-584.
    [15] Qiu Y,Deng Z W,Xu M,et al. New A-nor steroids and their antifouling activity from the Chinese marine sponge Acanthella cavernosa[J]. Steriods,2008,73(14):1500-1504.
    [16] 许磊,吴迪,吴立军,等. 辽细辛地上部分化学成分的分离与鉴定(2)[J]. 沈阳药科大学学报,2009,26(12):964-967.
    [17] Wang RP,Lin HW,Song SJ,et al. Monoindole alkaloids from a marine sponge Mycale fibrexilis[J]. Biochem Syst Ecol,2012,43(8):210-213.
    [18] Dillman RL,Cardellina JH. Aromatic secondary metabolites from the sponge Tedania Ignis[J]. J Nat Prod,1991,54(4):1056-1061.
    [19] Harrigan GG,Ahmad A,Baj N,et al. Bioactive and other sesquiterpenoids from Porella cordeana[J]. J Nat Prod,1993,56(6):921-925.
    [20] 王茹萍,吴迪,高慧媛,等. 天女木兰叶中甾类化合物的分离与鉴定[J]. 沈阳药科大学学报,2009,(11):874-877.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(4170) PDF downloads(25) Cited by()

Related
Proportional views

Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa

doi: 10.3969/j.issn.1006-0111.2016.02.011
  • No.425 Hospital of PLA, Sanya 572000, China
  • Received Date: 2015-08-11
  • Rev Recd Date: 2016-01-05

Abstract: Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20, and high-performance liquid chromatography(HPLC). Structures were determined by spectroscopic analysis and comparison with reported data. Results Nine compounds were isolated. Their structures were determined as kalihinol E(1), kalihinol A(2), 10-epi-kalihinol X(3), 10-epi-kalihinol I(4), 1H-indole-3-carboxylic acid methyl ester(5), 1H-indole-3-carboxylic acid(6), 3-buten-2-one,4-(2,3,6-trimethylphenyl)-(3E)(7), aristolone(8), and 5α, 8α-epidioxy-(22E, 24R)-erost-6, 22-dien-3β-ol(9). Conclusion Compounds 5 to 8 were isolated from the sponge of genus Acanthalla for the first time.

FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
Citation: FAN Wei, WANG Xudong, CAI Haimin, SUN Liguang, YANG Ling, NIE Suifeng. Chemical analysis of the South China Sea spine body sponge Acanthella cavernosa[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 138-141,166. doi: 10.3969/j.issn.1006-0111.2016.02.011
shu

    HTML

Reference (20)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return