Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A

CHI Qingqing; WANG Qiang; ZHONG Yanqiang

doi:10.3969/j.issn.1006-0111.2016.02.008

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2016 > 34(2): 124-128

CHI Qingqing, WANG Qiang, ZHONG Yanqiang. Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 124-128. doi: 10.3969/j.issn.1006-0111.2016.02.008

Citation:

CHI Qingqing, WANG Qiang, ZHONG Yanqiang. Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 124-128. doi: 10.3969/j.issn.1006-0111.2016.02.008

Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A

doi: 10.3969/j.issn.1006-0111.2016.02.008

1.
Dalian Medical University, Dalian 116044, China
2.
No.202 Hospital of PLA, Shenyang 110003, China
3.
Second Military Medical University, Shanghai 200433, China

Received Date: 2015-10-28
Rev Recd Date: 2016-01-25

Abstract

Glaucocalyxin A(GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene. It has various pharmacological activities, such as cardiovascular and endothelium cellular protection, anti-blood coagulation, anti-Hepatitis B Virus(HBV), anti-tumor, anti-bacteria, anti-inflammation, hypoxic tolerance, immunomodulation and Ca²⁺ concentration regulation effect, where as its in vivo safety is quite good. As a folk medicine, it is conventionally used to treat hepatitis, gastritis, mastitis, stomachache and arthralgia. It is also used for ischemic and/or hypoxic cardio-cerebrovascular diseases such as coronary heart diseases, stenocardia and chronic cerebral circulation insufficiency in clinic. This review gives a summary of the pharmacological effects, biological mechanism, and toxicity of Glaucocalyxin A.
- Glaucocalyxin A,
- Rabdosia(BI.) Hassk,
- pharmacological activity,
- toxicology

References

[1]	余祖胤.对映贝壳杉烷类二萜化合物抗肿瘤作用及其分子机制研究[D]. 中国人民解放军军事医学科学院,2007.
[2]	张冰月,郎轶咏,王强.蓝萼甲素抗血小板聚集的研究[J].中医药信息,2014,31(6):23-26.
[3]	张雯,宋俊科,杜冠华.缺血再灌注损伤与细胞凋亡信号转导通路[J].中国药学杂志, 2015,50(7):565-569.
[4]	Duan X, Ji BY, Wang XH, et al. Expression of microRNA-1 and microRNA-21 in different protocols of ischemic conditioning in an isolatedrat heart model[J]. Cardiology,2012,122(1):36-43.
[5]	Kang S, Yang YJ, Wu YL, et al. Myocardium and microvessel endothelium, apoptosis at day 7 following reperfused acute myocardial infarction[J]. Microvasc Res, 2010, 79(1):70-79.
[6]	刘明洁,孙旗,王强,等.蓝萼香茶菜总二萜预处理对兔心肌缺血/再灌注时心肌细胞凋亡的影响[J].中国实验方剂学杂志,2013,19(19):229-233.
[7]	李上海,梁伟钧,孙炎华,等.缺血预处理对心肌缺血再灌注诱发凋亡的保护机制[J].国际心血管病杂志,2014,41(1):48-50.
[8]	刘兰娣,叶丽卡,潘东军,等.蓝萼香茶菜对大鼠全心缺血-再灌注时心肌C-fos基因表达的影响[J].中国中药杂志,2003,28(4):358-361.
[9]	谷洁,隋海静,李冬梅,等.内皮素与一氧化氮在2型糖尿病大鼠心肌缺血再灌注损伤中的变化及意义[J].国际免疫学杂志, 2013,36(3):235-238.
[10]	夏龙,褚纯隽,严彪,等.蓝萼甲素对血管内皮细胞的保护作用[J].中医药导报,2014,20(4):22-24.
[11]	海广范,张慧,郭兰青.二萜类化合物药理学作用研究进展[J].新乡医学院学报,2015,32(1):77-80.
[12]	王保强,丁兰,达文燕,等.蓝萼香茶菜叶与茎乙醇提取物的抑菌活性研究[J].安徽农业科学,2010,38(31):17526-17528.
[13]	马占强,王敏,张健,等.蓝萼甲素抗凝血作用研究[J].云南中医学院学报,2011,34(3):26-29.
[14]	朱晓红,张冰月,王莹莹,等.蓝萼香茶菜总二萜对小鼠抗凝血作用[J].中国公共卫生2013,29(1):86-87.
[15]	汤晓蓉.蓝萼甲素对缺氧缺血性脑损伤保护作用的研究[D].苏州大学,2013.
[16]	HasegawaY,Suzuki H,Sozen T,et al.Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats[J].Stroke,2010,41(2):368-374.
[17]	Zhou Y, Lekic T, Fathali N,et al. Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway[J].Stroke, 2010. 41(7):1521-1527.
[18]	刘洪川,项昭保,金永生,等.蓝萼香茶菜化学成分与结构修饰及抗肿瘤和抗乙肝病毒作用研究[C].2013中国药学大会暨第十三届中国药师周论文集,2014.
[19]	王伟超. 核仁蛋白EBP2反馈调控转录因子c-Myc影响rDNA转录、细胞增殖以及肿瘤形成[D].华东师范大学,2015.
[20]	应娜,徐长亮,张健,等.蓝萼甲素对入肝癌细胞HepG2细胞株的作用[J].海峡药学,2012,24(1):235-238.
[21]	李梦姣,顾振纶,董丽霞,等.蓝萼甲素对人肺癌A549细胞的作用及其机制[J].中国药理学通报,2013,29(6):882.
[22]	Gao LW, Zhang J, Yang WH. Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway[J].Toxicol in vitro, 2011,25(1):51-63.
[23]	刘学忠,薛彬,袁燕,等.乐果引起大鼠肝细胞凋亡的机理[J].中国兽医学报,2010,30(1):98-101.
[24]	Xiong XX, Liu JM, Qiu XY, et al. Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways[J]. Acta Pharmacol Sin, 2015, 36(3):362-374.
[25]	杨文华,张健,高立文,等.蓝萼甲素诱导K562细胞毒作用机制的初步研究[J].中国实验方剂学杂志,2011,17(19):181-184.
[26]	黄敬敬,王修珍,蒋小岗,等.蓝萼甲素对宫颈HeLa细胞的作用及其相关机制研究[J].中国药理学通报,2012,28(3):421-424.
[27]	夏维,王修珍,蒋小岗,等.蓝萼甲素对人宫颈鳞癌SiHa细胞株生长抑制作用[J].中国药理学通报,2011,27(7):1035-1036.
[28]	陈子珺,李云森,周吉燕,等.蓝萼甲素对小鼠脾细胞Th1/Th2型5种细胞因子水平的影响[J].中国中药杂志,2006,31(15):1257-1260.
[29]	陈子珺,李云森,周吉燕,等.蓝萼甲素对小鼠脾细胞内游离钙离子浓度的影响[J].中草药,2006,37(6):908-910.
[30]	崔婷婷,赵丽娟,刘岩,等.蓝萼香茶菜的毒理学研究[J].中国医药指南,2010,08(19):246-249.
[31]	沈晓丹,曹莉,董霞,等.蓝萼甲素体外细胞毒活性研究[J].中华中医药学刊,2011,29(6):1334-1335.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A

1. Dalian Medical University, Dalian 116044, China

2. No.202 Hospital of PLA, Shenyang 110003, China

3. Second Military Medical University, Shanghai 200433, China

Received Date: 2015-10-28

Rev Recd Date: 2016-01-25

Key words:

Abstract: Glaucocalyxin A(GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene. It has various pharmacological activities, such as cardiovascular and endothelium cellular protection, anti-blood coagulation, anti-Hepatitis B Virus(HBV), anti-tumor, anti-bacteria, anti-inflammation, hypoxic tolerance, immunomodulation and Ca²⁺ concentration regulation effect, where as its in vivo safety is quite good. As a folk medicine, it is conventionally used to treat hepatitis, gastritis, mastitis, stomachache and arthralgia. It is also used for ischemic and/or hypoxic cardio-cerebrovascular diseases such as coronary heart diseases, stenocardia and chronic cerebral circulation insufficiency in clinic. This review gives a summary of the pharmacological effects, biological mechanism, and toxicity of Glaucocalyxin A.

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Reference (31)

[1]	余祖胤.对映贝壳杉烷类二萜化合物抗肿瘤作用及其分子机制研究[D]. 中国人民解放军军事医学科学院,2007.
[2]	张冰月,郎轶咏,王强.蓝萼甲素抗血小板聚集的研究[J].中医药信息,2014,31(6):23-26.
[3]	张雯,宋俊科,杜冠华.缺血再灌注损伤与细胞凋亡信号转导通路[J].中国药学杂志, 2015,50(7):565-569.
[4]	Duan X, Ji BY, Wang XH, et al. Expression of microRNA-1 and microRNA-21 in different protocols of ischemic conditioning in an isolatedrat heart model[J]. Cardiology,2012,122(1):36-43.
[5]	Kang S, Yang YJ, Wu YL, et al. Myocardium and microvessel endothelium, apoptosis at day 7 following reperfused acute myocardial infarction[J]. Microvasc Res, 2010, 79(1):70-79.
[6]	刘明洁,孙旗,王强,等.蓝萼香茶菜总二萜预处理对兔心肌缺血/再灌注时心肌细胞凋亡的影响[J].中国实验方剂学杂志,2013,19(19):229-233.
[7]	李上海,梁伟钧,孙炎华,等.缺血预处理对心肌缺血再灌注诱发凋亡的保护机制[J].国际心血管病杂志,2014,41(1):48-50.
[8]	刘兰娣,叶丽卡,潘东军,等.蓝萼香茶菜对大鼠全心缺血-再灌注时心肌C-fos基因表达的影响[J].中国中药杂志,2003,28(4):358-361.
[9]	谷洁,隋海静,李冬梅,等.内皮素与一氧化氮在2型糖尿病大鼠心肌缺血再灌注损伤中的变化及意义[J].国际免疫学杂志, 2013,36(3):235-238.
[10]	夏龙,褚纯隽,严彪,等.蓝萼甲素对血管内皮细胞的保护作用[J].中医药导报,2014,20(4):22-24.
[11]	海广范,张慧,郭兰青.二萜类化合物药理学作用研究进展[J].新乡医学院学报,2015,32(1):77-80.
[12]	王保强,丁兰,达文燕,等.蓝萼香茶菜叶与茎乙醇提取物的抑菌活性研究[J].安徽农业科学,2010,38(31):17526-17528.
[13]	马占强,王敏,张健,等.蓝萼甲素抗凝血作用研究[J].云南中医学院学报,2011,34(3):26-29.
[14]	朱晓红,张冰月,王莹莹,等.蓝萼香茶菜总二萜对小鼠抗凝血作用[J].中国公共卫生2013,29(1):86-87.
[15]	汤晓蓉.蓝萼甲素对缺氧缺血性脑损伤保护作用的研究[D].苏州大学,2013.
[16]	HasegawaY,Suzuki H,Sozen T,et al.Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats[J].Stroke,2010,41(2):368-374.
[17]	Zhou Y, Lekic T, Fathali N,et al. Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway[J].Stroke, 2010. 41(7):1521-1527.
[18]	刘洪川,项昭保,金永生,等.蓝萼香茶菜化学成分与结构修饰及抗肿瘤和抗乙肝病毒作用研究[C].2013中国药学大会暨第十三届中国药师周论文集,2014.
[19]	王伟超. 核仁蛋白EBP2反馈调控转录因子c-Myc影响rDNA转录、细胞增殖以及肿瘤形成[D].华东师范大学,2015.
[20]	应娜,徐长亮,张健,等.蓝萼甲素对入肝癌细胞HepG2细胞株的作用[J].海峡药学,2012,24(1):235-238.
[21]	李梦姣,顾振纶,董丽霞,等.蓝萼甲素对人肺癌A549细胞的作用及其机制[J].中国药理学通报,2013,29(6):882.
[22]	Gao LW, Zhang J, Yang WH. Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway[J].Toxicol in vitro, 2011,25(1):51-63.
[23]	刘学忠,薛彬,袁燕,等.乐果引起大鼠肝细胞凋亡的机理[J].中国兽医学报,2010,30(1):98-101.
[24]	Xiong XX, Liu JM, Qiu XY, et al. Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways[J]. Acta Pharmacol Sin, 2015, 36(3):362-374.
[25]	杨文华,张健,高立文,等.蓝萼甲素诱导K562细胞毒作用机制的初步研究[J].中国实验方剂学杂志,2011,17(19):181-184.
[26]	黄敬敬,王修珍,蒋小岗,等.蓝萼甲素对宫颈HeLa细胞的作用及其相关机制研究[J].中国药理学通报,2012,28(3):421-424.
[27]	夏维,王修珍,蒋小岗,等.蓝萼甲素对人宫颈鳞癌SiHa细胞株生长抑制作用[J].中国药理学通报,2011,27(7):1035-1036.
[28]	陈子珺,李云森,周吉燕,等.蓝萼甲素对小鼠脾细胞Th1/Th2型5种细胞因子水平的影响[J].中国中药杂志,2006,31(15):1257-1260.
[29]	陈子珺,李云森,周吉燕,等.蓝萼甲素对小鼠脾细胞内游离钙离子浓度的影响[J].中草药,2006,37(6):908-910.
[30]	崔婷婷,赵丽娟,刘岩,等.蓝萼香茶菜的毒理学研究[J].中国医药指南,2010,08(19):246-249.
[31]	沈晓丹,曹莉,董霞,等.蓝萼甲素体外细胞毒活性研究[J].中华中医药学刊,2011,29(6):1334-1335.

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Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A

doi: 10.3969/j.issn.1006-0111.2016.02.008

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References

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通讯作者: 陈斌, bchen63@163.com

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