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Volume 34 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(2): 116-118,173

BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
Citation: BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
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The high adaptability and metabolism of Candida albicans

doi: 10.3969/j.issn.1006-0111.2016.02.006

  • New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2015-08-23
  • Rev Recd Date: 2015-09-29
  • Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal treatment. The growth and reproduction of C. albicans is accompanied with metabolism process. C. albicans can use a wide range of carbon and nitrogen sources, and it is sensitive to the alteration of nutrition. Recent studies reveal that the environment affects the metabolism of C. albicans, whilst C. albicans regulates its metabolism to adapt to the environment. Therefore, further study on the relationship between metabolism and high adaptability of C. albicans is helpful to discover novel antifungal targets.
  • [1] Guinea J. Global trends in the distribution of Candida species causing candidemia[J]. Clin Microbiol Infect, 2014, 20(Suppl 6):5-10.
    [2] Cottier F, Pavelka N. Complexity and dynamics of host-fungal interactions[J]. Immunol Res, 2012, 53(1-3):127-135.
    [3] Romani L, Zelante T, Palmieri M, et al. The cross-talk between opportunistic fungi and the mammalian host via microbiota's metabolism[J]. Semin Immunopathol, 2015, 37(2):163-171.
    [4] Mallick EM, Bennett RJ. Sensing of the microbial neighborhood by Candida albicans[J]. PLoS Pathog, 2013, 9(10):e1003661.
    [5] Staniszewska M, Bondaryk M, Pilat J, et al. Virulence factors of Candida albicans[J]. Przegl Epidemiol, 2012, 66(4):629-633.
    [6] Zhu W, Filler S G. Interactions of Candida albicans with epithelial cells[J]. Cell Microbiol, 2010, 12(3):273-282.
    [7] Hoyer LL. The ALS gene family of Candida albicans[J]. Trends Microbiol, 2001, 9(4):176-180.
    [8] Sun N, Fonzi W, Chen H, et al. Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants[J]. Antimicrob Agents Chemother, 2013, 57(1):532-542.
    [9] Prasad R, Rawal MK. Efflux pump proteins in antifungal resistance[J]. Front Pharmacol, 2014, 5:202.
    [10] Ene IV, Adya AK, Wehmeier S, et al. Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen[J]. Cell Microbiol, 2012, 14(9):1319-1335.
    [11] Lorenz MC, Fink GR. The glyoxylate cycle is required for fungal virulence[J]. Nature, 2001, 412(6842):83-86.
    [12] Cheah HL, Lim V, Sandai D. Inhibitors of the glyoxylate cycle enzyme ICL1 in Candida albicans for potential use as antifungal agents[J]. PLoS One, 2014, 9(4):e95951.
    [13] Kemsawasd V, Viana T, Ardo Y, et al. Influence of nitrogen sources on growth and fermentation performance of different wine yeast species during alcoholic fermentation[J]. Appl Microbiol Biotechnol, 2015.
    [14] Gagiano M, Bauer F-F, Pretorius IS. The sensing of nutritional status and the relationship to filamentous growth in Saccharomyces cerevisiae[J]. FEMS Yeast Res, 2002, 2(4):433-470.
    [15] Buu LM, Chen YC. Impact of glucose levels on expression of hypha-associated secreted aspartyl proteinases in Candida albicans[J]. J Biomed Sci, 2014, 21:22.
    [16] Han TL, Cannon RD, Villas-B? as S-G. The metabolic basis of Candida albicans morphogenesis and quorum sensing[J]. Fungal Genet Biol, 2011, 48(8):747-763.
    [17] Brown AJ, Brown GD, Netea MG, et al. Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels[J]. Trends Microbiol, 2014, 22(11):614-622.
    [18] Vieira N, Casal M, Johansson B, et al. Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans[J]. Mol Microbiol, 2010, 75(6):1337-1354.
    [19] Kitahara N, Morisaka H, Aoki W, et al. Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation[J]. Amb Express, 2015, 5(1):127.
    [20] Ramirez MA, Lorenz MC. Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes[J]. Eukaryot Cell, 2007, 6(2):280-290.
    [21] Sellam A, van het Hoog M, Tebbji F, et al. Modeling the transcriptional regulatory network that controls the early hypoxic response in Candida albicans[J]. Eukaryot Cell, 2014, 13(5):675-690.
    [22] Dunkel N, Biswas K, Hiller E, et al. Control of morphogenesis, protease secretion and gene expression in Candida albicans by the preferred nitrogen source ammonium[J]. Microbiology, 2014, 160(Pt 8):1599-1608.
    [23] Ramachandra S, Linde J, Brock M, et al. Regulatory networks controlling nitrogen sensing and uptake in Candida albicans[J]. PLoS One, 2014, 9(3):e92734.
    [24] Yan L, Zhang JD, Cao YB, et al. Proteomic analysis reveals a metabolism shift in a laboratory fluconazole-resistant Candida albicans strain[J]. J Proteome Res, 2007, 6(6):2248-2256.
    [25] Xu Y, Sheng F, Zhao J, et al. ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates[J]. Arch Microbiol, 2015.
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The high adaptability and metabolism of Candida albicans

doi: 10.3969/j.issn.1006-0111.2016.02.006
  • New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2015-08-23
  • Rev Recd Date: 2015-09-29

Abstract: Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal treatment. The growth and reproduction of C. albicans is accompanied with metabolism process. C. albicans can use a wide range of carbon and nitrogen sources, and it is sensitive to the alteration of nutrition. Recent studies reveal that the environment affects the metabolism of C. albicans, whilst C. albicans regulates its metabolism to adapt to the environment. Therefore, further study on the relationship between metabolism and high adaptability of C. albicans is helpful to discover novel antifungal targets.

BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
Citation: BI Shuang, HU Dandan, JIANG Yuanying, WANG Yan. The high adaptability and metabolism of Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
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