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Volume 34 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 83-85,89

BAO Siwei, ZHANG Yuyi, HU Yanming, ZHAI Xiaobo, HE Zhigao. Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 83-85,89. doi: 10.3969/j.issn.1006-0111.2016.01.022
Citation: BAO Siwei, ZHANG Yuyi, HU Yanming, ZHAI Xiaobo, HE Zhigao. Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 83-85,89. doi: 10.3969/j.issn.1006-0111.2016.01.022
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Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime

doi: 10.3969/j.issn.1006-0111.2016.01.022
  • 1.

    Department of Pharmacy, East Hospital of Tongji University, Shanghai 200120, China

  • 2.

    Nursing department, East Hospital of Tongji University, Shanghai 200120, China

  • Received Date: 2014-10-21
  • Rev Recd Date: 2015-03-18
  • Objective The aim of the study is to evaluate clinical efficacy and safety of azatreonam or ceftazidime on treatment of lower respiratory tract infection. Methods Four English databases (MEDLINE、EMBASE、Pubmed、Cochrane library) and three Chinese databases (CNKI、VIP、WANFANG) were searched. Meta-analysis was performed using Review Manager 5.2. Results The Meta-analysis revealed azatreonam was superior to ceftazidime in total efficiency (RR=1.15,95% CI is 1.09-1.21). No significant differences are seen between azatreonam and ceftazidime (RR=1.03,95% CI is 0.98-1.09) on the bacterial eradication rates or the incidence of adverse reactions (RR=0.66,95% CI is 0.39-1.12). Conclusion Azatreonam is more effective than ceftazidime on the treatment of lower respiratory tract infection in the clinical practice.
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    [2] 黄文智,李淑英. 下呼吸道感染病原菌分布及耐药性分析[J]. 中华医院感染学杂志,2008,18(9):1328-1330.
    [3] Jüni P,Altman DG,Egger M.Systematic reviews in health care: Assessing the quality of controlled clinical trials[J].BMJ,2001,323(7303):42-46.
    [4] 唐英春,张扣兴,张月莉,等. 氨曲南治疗60例老年下呼吸道细菌感染的多中心随机对照研究[J]. 中国新药与临床杂志,2004,23(1):13-17.
    [5] 张 进. 氨曲南治疗下呼吸道感染67例疗效观察[J]. 中国医药指南,2012,10(29):453-454.
    [6] 李文芳. 氨曲南治疗下呼吸道感染患者的临床疗效观察[J]. 中国社区医师(医学专业半月刊),2008,10(183):32.
    [7] 范照冬,王金柱,孔祥臣.氨曲南治疗下呼吸道感染疗效分析[J].医药世界,2009,11(7):304-305.
    [8] 孙喜梅. 氨曲南治疗下呼吸道感染疗效分析[J]. 医学信息(中旬刊),2011,24(3):1080.
    [9] 杨 杰. 氨曲南治疗下呼吸道感染临床观察[J]. 亚太传统医药,2010,6(1):83-84.
    [10] 周燕萍.氨曲南治疗肿瘤患者下呼吸道感染的临床疗效观察[J].中国药房,2006,17(3):202-203.
    [11] 杜文平.氨曲南治疗下呼吸道感染临床观察[J].健康大视野,2013,21(3):404-404.
    [12] 徐英男.氨曲南治疗下呼吸道感染临床疗效观察[J].中国中医药咨讯,2010,02(32):49.
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Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime

doi: 10.3969/j.issn.1006-0111.2016.01.022
  • 1. Department of Pharmacy, East Hospital of Tongji University, Shanghai 200120, China
  • 2. Nursing department, East Hospital of Tongji University, Shanghai 200120, China
  • Received Date: 2014-10-21
  • Rev Recd Date: 2015-03-18

Abstract: Objective The aim of the study is to evaluate clinical efficacy and safety of azatreonam or ceftazidime on treatment of lower respiratory tract infection. Methods Four English databases (MEDLINE、EMBASE、Pubmed、Cochrane library) and three Chinese databases (CNKI、VIP、WANFANG) were searched. Meta-analysis was performed using Review Manager 5.2. Results The Meta-analysis revealed azatreonam was superior to ceftazidime in total efficiency (RR=1.15,95% CI is 1.09-1.21). No significant differences are seen between azatreonam and ceftazidime (RR=1.03,95% CI is 0.98-1.09) on the bacterial eradication rates or the incidence of adverse reactions (RR=0.66,95% CI is 0.39-1.12). Conclusion Azatreonam is more effective than ceftazidime on the treatment of lower respiratory tract infection in the clinical practice.

BAO Siwei, ZHANG Yuyi, HU Yanming, ZHAI Xiaobo, HE Zhigao. Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 83-85,89. doi: 10.3969/j.issn.1006-0111.2016.01.022
Citation: BAO Siwei, ZHANG Yuyi, HU Yanming, ZHAI Xiaobo, HE Zhigao. Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 83-85,89. doi: 10.3969/j.issn.1006-0111.2016.01.022
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