Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 34 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 44-47

TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
Citation: TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
shu

Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone

doi: 10.3969/j.issn.1006-0111.2016.01.012
  • 1.

    Xinjiang Medical University, Urumqi 830002, China;Xinjiang Uygur Autonomous Region Institute for Food and Drug Control, Urumqi 830004, China

  • 2.

    Xinjiang Medical University, Urumqi 830002, China

  • Received Date: 2014-12-27
  • Rev Recd Date: 2015-07-21
  • Objective To prepare hot-melt pressure sensitive adhesive (HMPSA) transdermal patches of progesterone and investigate the release characterization in vitro. Methods SIS HMPSA was used as matrix material, modified Franz diffusion cell and excised female rat skin were used as model,the concentration of progesterone was determined by HPLC. The thickness of patch and penetration enhancers was screened out by permeation rate. Results 2% IPM was used to prepare progesterone HMPSA transdermal patch, thickness was 300 μm, the cumulative permeation curve was Q=6.172 1 t-5.457 7 (r=0.998 8). The cumulative releases of the patches in 24 h was 144.17 μg/cm2. The permeation rate was (6.17±0.49) μg/(cm2·h). Conclusion The progesterone HMPSA transdermal patch had good transdermal release in vitro, which would have good clinical application prospect.
  • [1] 吴燕青,辛 虹.孕激素在激素替代疗法中的作用[J].国外医学计划生育分册,2003,23(1):37-40.
    [2] 黄建新,陈超慧.肌肉注射黄体酮局部不良反应的观察及护理[J].当代护士,2007,(1):66-67.
    [3] 靳 阳,李建民.黄体酮透皮吸收研究[J].南开大学学报,1997,30(4):21-25.
    [4] 马建芳,罗华菲,王 浩.睾酮热熔压敏胶透皮贴剂的研制[J]. 中国药学杂志,2012,47(21):1727-1731.
    [5] 俞振伟,应晓英,梁文权.热熔压敏胶中药物释放性能的研究[J].中国药学杂志,2009,44(24):1878-1882.
    [6] 王承潇,汤秀珍,沈平婊,等.热熔压敏胶应用于中药贴剂的研究进展[J].中草药,2010,41(3):496-499.
    [7] 龙利红,黄 群,侯淑贤,等.黄体酮缓释栓的制备及药动学[J].中国医院药学杂志,2006,26(2):156-160.
    [8] 张立雯.血浆和子宫中黄体酮和代谢物的测定及黄体酮膜的局部吸收研究[D].四川:四川大学,2004:6.
    [9] 孔雅慧.黄体酮硅橡胶阴道环(PVR)在家兔的药代动力学及药效学研究[D].上海:复旦大学,2006:7.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3141) PDF downloads(115) Cited by()

Related
Proportional views

Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone

doi: 10.3969/j.issn.1006-0111.2016.01.012
  • 1. Xinjiang Medical University, Urumqi 830002, China;Xinjiang Uygur Autonomous Region Institute for Food and Drug Control, Urumqi 830004, China
  • 2. Xinjiang Medical University, Urumqi 830002, China
  • Received Date: 2014-12-27
  • Rev Recd Date: 2015-07-21

Abstract: Objective To prepare hot-melt pressure sensitive adhesive (HMPSA) transdermal patches of progesterone and investigate the release characterization in vitro. Methods SIS HMPSA was used as matrix material, modified Franz diffusion cell and excised female rat skin were used as model,the concentration of progesterone was determined by HPLC. The thickness of patch and penetration enhancers was screened out by permeation rate. Results 2% IPM was used to prepare progesterone HMPSA transdermal patch, thickness was 300 μm, the cumulative permeation curve was Q=6.172 1 t-5.457 7 (r=0.998 8). The cumulative releases of the patches in 24 h was 144.17 μg/cm2. The permeation rate was (6.17±0.49) μg/(cm2·h). Conclusion The progesterone HMPSA transdermal patch had good transdermal release in vitro, which would have good clinical application prospect.

TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
Citation: TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
shu

    HTML

Reference (9)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return