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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 8-11,47

ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

Circadian rhythms of myocardial ischemia and chronotherapy

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China;Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 2.

    Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 3.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China

  • Received Date: 2014-09-19
  • Rev Recd Date: 2015-04-28
  • The occurrence of the clinical manifestations of myocardial ischemia shows clear circadian rhythmicity, and they are unevenly distributed during the 24 h with higher morbidity during the initial hours of the daily activity span and in the late afternoon or early evening. Such temporal patterns result from circadian rhythms in pathophysiological mechanisms plus cyclic environmental stressors that trigger these clinical events. β-receptor antagonist medications, oral nitrate, and calcium channel blocker have been shown to be influenced by the circadian time of their administration. Here we briefly review the characteristics of circadian rhythmicity in MI, the pathophysiological mechanisms as well as the current chronotherapy,and then discuss the future treatment strategies.
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Circadian rhythms of myocardial ischemia and chronotherapy

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1. Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China;Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China
  • 2. Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China
  • 3. Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China
  • Received Date: 2014-09-19
  • Rev Recd Date: 2015-04-28

Abstract: The occurrence of the clinical manifestations of myocardial ischemia shows clear circadian rhythmicity, and they are unevenly distributed during the 24 h with higher morbidity during the initial hours of the daily activity span and in the late afternoon or early evening. Such temporal patterns result from circadian rhythms in pathophysiological mechanisms plus cyclic environmental stressors that trigger these clinical events. β-receptor antagonist medications, oral nitrate, and calcium channel blocker have been shown to be influenced by the circadian time of their administration. Here we briefly review the characteristics of circadian rhythmicity in MI, the pathophysiological mechanisms as well as the current chronotherapy,and then discuss the future treatment strategies.

ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
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