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JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
Citation: JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006

The antitumor effect of snake venom toxins and its application in medical field

doi: 10.3969/j.issn.1006-0111.2015.06.006
  • Received Date: 2013-09-01
  • Rev Recd Date: 2014-03-31
  • Objective To discuss the antitumor effect of snake venom toxins and its application in medical field. Methods To review the research progress of composition, the antitumor effect and mechanism of snake venom toxins. Results It was demonstrated that the snake venom toxins can stop various tumor cells from growing, and have the functions of killing the tumor cells, inducing cell death, and inhibition of angiogenesis. Conclusion It is an important direction in antitumor drug research and development to deeply research the composition and the mechanisms of action of the snake venom toxins.
  • [1] Matsui T, Fujimura Y, Koiti T. Snake venom proteases aiecting hemostasis and thrombosis[J].Biochim Biophys Acta,2000, 1477(1-2):146-156.
    [2] Lauterwein J.Wuthrich K.A possible structural basis for the difierdnt models of action of neurotoxins and carditotoxins from snake venon1[J].FEBS Lett,1978,93(2):181-184.
    [3] Jokhio R,Ansari AF.Cobra snake venom reduces significantly tissue nucleic acid levels in human breast cancer[J].J Pak Med Assoc,2005,55(2):71-73.
    [4] Xie Q,Wan R,Lin X,et al.Effects of snake venom cystatin gene on gene expression profiles in mouse melanoma cell line B16F1[J].Chin Cancer,2008,27(7):716-722.
    [5] da Sliva RJ,da Sliva MG,Vilela LC,et al.Antitumor efect of Bothrops jararaca venom[J].Mediators Inflamm,2002,11(2):99-104.
    [6] Kini RM.Platelet aggregation and exogenous factors from animalsources[J].Curr Drug Targ Cardiovasc Haematol Disord,2004,4(4):301-325.
    [7] de Carvalho DD, Schmitmeier S, Novello JC, et al.Effect of BJcuL (a lectin from the venom of the snake Bothrops jararacussu) on adhesion and growth of tumor and endothelial cells[J].Toxicon, 2001, 39(10): 1471-1476.
    [8] Torii S,Naito M, Tsuruo T. Apoxin I,a novel apoptosis inducingfactor with L-amino acid oxidase activity purified from western diamondback rattlesnake venom[J].Biol Chem,1997,272(14):9539-9542.
    [9] Guo CM, Liu SQ, Yao YW. Past decade study of snake venom L-amino acid oxidase[J].Toxicon, 2012, 60(3) : 302-311.
    [10] Samel M, Vija H, Rönnholm G,et al. Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom[J].Biochim Biophys Acta,2006, 1764(4):707-714.
    [11] Kanzawa N,Shintani S,Ohta K,et al. Achacin induces cell death in HeLa cells through two different mechanisms[J].Arch Biochem Biophys,2004, 422(1): 103-109.
    [12] Alves RM, Antonucci GA, Paiva HH,et al. Evidence of caspase mediatedapoptosis induced by L-amino acid oxidase isolated fromBothrops atrox snake venom[J].Comp Biochem Physiol A,2008,151(4):542-550.
    [13] de Melo Alves Paiva R, de Freitas Figueiredo R, Antonucci GA,et al. Cell cycle arrest evidence, parasiticidal and bactericidal properties induced by L-amino acid oxidase from Bothrops atrox snake venom[J].Bchimie,2011, 93(5): 941-947.
    [14] Zhang L, Wu WT. Isolation and characterization of ACTX-6:a cytotoxic L-amino acid oxidase from Agkistrodonacutus snake venom[J].Nat Prod Res,2008, 22(6): 554-563.
    [15] Chen X, Lv P, Liu J, et al. Apoptosis of human hepatocellular carcinoma cell (HepG2) induced by cardiotoxin III through sphase arrest [J].Toxicol Pathol, 2009,61(4): 307-315.
    [16] Zhang L, Cui L. A cytotoxin isolated from Agkistrodonacutus snake venom induces apoptosis via Fas pathway in A549 cells[J].Toxicol In Vitro, 2007,21(6): 1095-1103.
    [17] Golubkov V, Hawes D, Markland FS. Anti-angiogenic activity ofeontortrostatin,a disintegrin from Agkistrodon contortrix snake venom[J].Angiogenesis,2003,6(3):213-224.
    [18] Yeh CH,Peng HC,Yang RS,et al .Rhodostomin,a snake venom disintegrin,inhibits angiogenesis elicited by basic fibroblast growthfactor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells[J].Mol Pharmacol,2001,59(5):1333-1342.
    [19] Zhang L, Cui L. A cytotoxin isolated from Agkistrodonacutus snake venom induces apoptosis via Fas pathway in A549 cells[J].Toxicol In Vitro, 2007,21(6): 1095-1103.
    [20] El-Refaei MF, Sarkar NH. Snake venom inhibits the growth of mouse mammary tumor cells in vitro and in vivo[J].Toxicon, 2009,54(1): 33-41.
    [21] de Melo Alves Paiva R, de Freitas Figueiredo R, Antonucci GA,et al. Cell cycle arrest evidence, parasiticidal and bactericidal properties induced by L-amino acid oxidase from Bothrops atrox snake venom[J].Bchimie,2011, 93(5): 941-947.
    [22] Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target[J]. Nature,2005,438(7070): 967-974.
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The antitumor effect of snake venom toxins and its application in medical field

doi: 10.3969/j.issn.1006-0111.2015.06.006

Abstract: Objective To discuss the antitumor effect of snake venom toxins and its application in medical field. Methods To review the research progress of composition, the antitumor effect and mechanism of snake venom toxins. Results It was demonstrated that the snake venom toxins can stop various tumor cells from growing, and have the functions of killing the tumor cells, inducing cell death, and inhibition of angiogenesis. Conclusion It is an important direction in antitumor drug research and development to deeply research the composition and the mechanisms of action of the snake venom toxins.

JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
Citation: JIN Xilin, ZHANG Jie, JIANG Hailong, LU Yiming. The antitumor effect of snake venom toxins and its application in medical field[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 502-504,517. doi: 10.3969/j.issn.1006-0111.2015.06.006
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