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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(5): 453-456

YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
Citation: YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
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One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review

doi: 10.3969/j.issn.1006-0111.2015.05.020

  • Department of Biotherapy, Eastern Hepatobiliary Surgical Hospital, Shanghai 200438, China

  • Received Date: 2015-01-12
  • Rev Recd Date: 2015-04-28
  • In recent years, with a large number of chemotherapy development, the incidence of secondary leukemia increased year by year,an acute myelomonocytic leukemia after chemotherapy and radiotherapy in 1 case of ovarian cancer and breast cancer was reported. The time from first chemotherapy to acute leukemia onset was 37 months. This patient had rapid onset and short survival period. Reports in the literature suggested that alkylating agents, topoisomerase I inhibitors, platinum were all easy to induce secondary leukemia. Hematopoietic stem cell transplantation coud reduce mortality and prolong progression free survival.
  • [1] Smit CG, Meyler L.Acute myeloid leukaemia after treatment with cytostatic agents[J]. Lancet, 1970, 2(7674):671-672.
    [2] Leone G,Voso MT,Sica S, et al, Therapy related leukemias: susceptibility, prevention and treatment[J]. Leuk Lymphoma, 2001,41 (3-4): 255-276.
    [3] 肖志坚,都玉书.继发性白血病的研究现况[J].中华血液学杂志,2001,22(11):613-616.
    [4] Markman M. Chronic myelocytic leukemia as a secondary malignant condition in a patient receiving prolonged chemotherapy for ovarian carcinoma[J]. West J Med,1985,143 (2): 243.
    [5] Atichartakarn V, Punyammalee B, Nitiyanant P. Therapy related acute non-lymphocytic leukemia: report of 4 cases[J].Southeast Asian J Trop Med Public Health,1985, 16(3):421-430.
    [6] 夏忠军.卵巢癌化疗的继发性白血病[J].国际内科学杂志,1991,2(3):22-24.
    [7] Chambers SK, Chopyk RL, Chambers JT, et al, Development of leukemia after doxorubicin and cisplatin treatment for ovarian cancer[J]. Cancer, 1989,64 (12): 2459-2461.
    [8] Yokoyama Y, Futagami M, Fukushi Y, et al, Secondary acute nonlymphocytic leukemia following successful chemotherapy combining cisplatin, doxorubicin and cyclophosphamide for stage IV epithelial ovarian cancer[J]. Arch Gynecol Obstet,2000,263 (4): 206-207.
    [9] Travis LB, Holowaty EJ, Bergfeldt K, et al, Risk of leukemia after platinum-based chemotherapy for ovarian cancer[J]. N Engl J Med, 1999,340 (5): 351-357.
    [10] Yeasmin S, Nakayama K, Ishibashi M, et al, Therapy-related myelodysplasia and acute myeloid leukemia following paclitaxel-and carboplatin-based chemotherapy in an ovarian cancer patient: a case report and literature review[J]. Int J Gynecol Cancer, 2008,18 (6): 1371-1376.
    [11] Ishikawa M, Nakayama K, Rahman MT, et al, Therapy-related myelodysplastic syndrome and acute myeloid leukemia following chemotherapy (paclitaxel and carboplatin) and radiation therapy in ovarian cancer: a case report[J]. Eur J Gynaecol Oncol,2014,35 (4): 443-448.
    [12] Vay A, Kumar S, Seward S, et al, Therapy-related myeloid leukemia after treatment for epithelial ovarian carcinoma: an epidemiological analysis[J]. Gynecol Oncol,2011,123 (3): 456-460.
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One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review

doi: 10.3969/j.issn.1006-0111.2015.05.020
  • Department of Biotherapy, Eastern Hepatobiliary Surgical Hospital, Shanghai 200438, China
  • Received Date: 2015-01-12
  • Rev Recd Date: 2015-04-28

Abstract: In recent years, with a large number of chemotherapy development, the incidence of secondary leukemia increased year by year,an acute myelomonocytic leukemia after chemotherapy and radiotherapy in 1 case of ovarian cancer and breast cancer was reported. The time from first chemotherapy to acute leukemia onset was 37 months. This patient had rapid onset and short survival period. Reports in the literature suggested that alkylating agents, topoisomerase I inhibitors, platinum were all easy to induce secondary leukemia. Hematopoietic stem cell transplantation coud reduce mortality and prolong progression free survival.

YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
Citation: YANG Xijing, ZHOU Fuping, ZHANG Qian, QIAN Qijun. One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 453-456. doi: 10.3969/j.issn.1006-0111.2015.05.020
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