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Volume 33 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(5): 451-452

LIU Binguo, ZHANG Xinping. Determination of the content of baicalin in Qiguanyan granules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 451-452. doi: 10.3969/j.issn.1006-0111.2015.05.019
Citation: LIU Binguo, ZHANG Xinping. Determination of the content of baicalin in Qiguanyan granules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 451-452. doi: 10.3969/j.issn.1006-0111.2015.05.019
shu

Determination of the content of baicalin in Qiguanyan granules by HPLC

doi: 10.3969/j.issn.1006-0111.2015.05.019

  • No.254 Hospital of PLA, Tianjin 300142, China

  • Received Date: 2014-07-04
  • Rev Recd Date: 2014-11-27
  • Objective To establish a method of HPLC for the determination of baicalin in Qiguanyan granules. Methods HPLC was performed on ZORBAX SB-C18(4.6 mm×150 mm,5 μm) column with mobile phase consisted of methanol-0.1% phosphoric acid (47:53) at ambient temperature.The flow rate was 1.0 ml/min.The detection wavelength was 280 nm. Results Baicalin showed a good linearity in the range of 6.63-210 μg/ml(r=0.999 8,n=6),and the average recovery was 98.16% (RSD=1.89%). Conclusion This methods was simple,accurate,sensitive,reproducible and reliable,which was suitable for the content control of Qiguanyan granules.
  • [1] 国家药典委员会.中华人民共和国药典2010年版二部[S].北京:中国医药科技出版社,2010:282-283.
    [2] 于天杰,张玲昂.HPLC法测定退烧颗粒中黄芩苷的含量[J].中国药师,2010,13(1):143-144.
    [3] 沈雪梅,何 伟,李 勇.RP-HPLC法测定清热和胃颗粒中黄芩苷的含量[J].广东药学院学报,2006,22(3):268-169.
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Determination of the content of baicalin in Qiguanyan granules by HPLC

doi: 10.3969/j.issn.1006-0111.2015.05.019
  • No.254 Hospital of PLA, Tianjin 300142, China
  • Received Date: 2014-07-04
  • Rev Recd Date: 2014-11-27

Abstract: Objective To establish a method of HPLC for the determination of baicalin in Qiguanyan granules. Methods HPLC was performed on ZORBAX SB-C18(4.6 mm×150 mm,5 μm) column with mobile phase consisted of methanol-0.1% phosphoric acid (47:53) at ambient temperature.The flow rate was 1.0 ml/min.The detection wavelength was 280 nm. Results Baicalin showed a good linearity in the range of 6.63-210 μg/ml(r=0.999 8,n=6),and the average recovery was 98.16% (RSD=1.89%). Conclusion This methods was simple,accurate,sensitive,reproducible and reliable,which was suitable for the content control of Qiguanyan granules.

LIU Binguo, ZHANG Xinping. Determination of the content of baicalin in Qiguanyan granules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 451-452. doi: 10.3969/j.issn.1006-0111.2015.05.019
Citation: LIU Binguo, ZHANG Xinping. Determination of the content of baicalin in Qiguanyan granules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 451-452. doi: 10.3969/j.issn.1006-0111.2015.05.019
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