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Volume 33 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(5): 445-447

ZHANG Minxin, HUANG Aiwen, SONG Hongtao. Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
Citation: ZHANG Minxin, HUANG Aiwen, SONG Hongtao. Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
shu

Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC

doi: 10.3969/j.issn.1006-0111.2015.05.017

  • Department of Pharmacy, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China

  • Received Date: 2014-10-13
  • Rev Recd Date: 2015-01-13
  • Objective To establish an HPLC method for determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution. Methods Phenomenex Hydro-RP (250 mm×4.6 mm, 4 μm) was adopted. Acetonitnile (A) and 0.1% phosphonic acid solution (0.1% triethanolamine solution)(B) was used as gradient mobile phase(0-20 min, 3%→10% A)at flow rate was 1.0 ml/min and the program of UV gradient absorbance detection was 210 nm. The sample volume was 20 μl. Results A good linearity was obtained over the concentration range of 0.99-39.6 μg/ml for ephedrine hydrochloride (r=0.999 9) and 1.09-43.6 μg/ml for pseudoephedrine hydrochloride (r=0.999 9). The average recovery of ephedrine hydrochloride was 101.5% with RSD of 1.77% (n=6), and the average recovery of pseudoephedrine hydrochloride was 100.8% with RSD of 1.96% (n=6). Conclusion This method was simple,accurate and quick,which could be used for determination and quality control of Maxing oral solution with good selectivity and repeatability.
  • [1] 中国人民解放军总后勤部. 中国人民解放军医疗机构制剂规范[S]. 北京:人民军医出版社,2002:35-36.
    [2] 李 翔,刘皈阳.HPLC法测定麻杏口服液中苦杏林苷的含量[J].解放军药学学报,2013,29(1):57-59.
    [3] 边向阳,江希连.高效液相色谱法测定麻杏口服液中绿原酸和黄芩苷的含量[J].海峡药学,2010,22(5):75-76.
    [4] 国家药典委员会.中华人民共和国药典2010年版一部[S]. 北京:中国医药科技出版社,2010: 495-496,300-301.
    [5] 王泽民.当代结构药物全集[M].北京:北京科学技术出版社,1993:1620-1621.
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Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC

doi: 10.3969/j.issn.1006-0111.2015.05.017
  • Department of Pharmacy, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou 350025, China
  • Received Date: 2014-10-13
  • Rev Recd Date: 2015-01-13

Abstract: Objective To establish an HPLC method for determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution. Methods Phenomenex Hydro-RP (250 mm×4.6 mm, 4 μm) was adopted. Acetonitnile (A) and 0.1% phosphonic acid solution (0.1% triethanolamine solution)(B) was used as gradient mobile phase(0-20 min, 3%→10% A)at flow rate was 1.0 ml/min and the program of UV gradient absorbance detection was 210 nm. The sample volume was 20 μl. Results A good linearity was obtained over the concentration range of 0.99-39.6 μg/ml for ephedrine hydrochloride (r=0.999 9) and 1.09-43.6 μg/ml for pseudoephedrine hydrochloride (r=0.999 9). The average recovery of ephedrine hydrochloride was 101.5% with RSD of 1.77% (n=6), and the average recovery of pseudoephedrine hydrochloride was 100.8% with RSD of 1.96% (n=6). Conclusion This method was simple,accurate and quick,which could be used for determination and quality control of Maxing oral solution with good selectivity and repeatability.

ZHANG Minxin, HUANG Aiwen, SONG Hongtao. Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
Citation: ZHANG Minxin, HUANG Aiwen, SONG Hongtao. Simultaneous determination of ephedrine hydrochloride and pseudoephedrine hydrochloride in Maxing oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 445-447. doi: 10.3969/j.issn.1006-0111.2015.05.017
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