Pharmaceutical studies on thermos sensitive insulin anal liquid suppository

LIU Dan; ZHAO Wencui; XIAO Qiusheng; WANG Yanping; ZHANG Qi; YANG Wenhui

doi:10.3969/j.issn.1006-0111.2015.05.010

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Objective To study the pharmaceutical quality of the thermos sensitive insulin anal liquid suppository. Methods Orthogonal test method was used, the forming of a gelatum time, gel strength, bio-adhesive force, viscosity, gelation temperature were taken as the evaluation index, the prescription of poloxamer 407 and poloxamer 188, the proportion of chitosan and pH were investigated, in order to determine the best optimized prescription and measure what was the best choice of the gel strength, biological adhesion force, suppository viscosity, gelation temperature for the final prescription of liquid suppository. Result The best combination of the prescription were 15% of poloxamer 407,25% of poloxamer 188 and 0.4% of chitosan with the pH of 5±0.2. Conclusion The test proved to be equitable with the good intensity and bio-adhesive force of the liquid suppository.

Pharmaceutical studies on thermos sensitive insulin anal liquid suppository

1. No.208 Hospital of PLA, Changchun 130000, China

2. School of Pharmacy, Yanbian University, Yanji 133000, China

Received Date: 2014-05-21

Rev Recd Date: 2015-03-20

Key words:

Abstract: Objective To study the pharmaceutical quality of the thermos sensitive insulin anal liquid suppository. Methods Orthogonal test method was used, the forming of a gelatum time, gel strength, bio-adhesive force, viscosity, gelation temperature were taken as the evaluation index, the prescription of poloxamer 407 and poloxamer 188, the proportion of chitosan and pH were investigated, in order to determine the best optimized prescription and measure what was the best choice of the gel strength, biological adhesion force, suppository viscosity, gelation temperature for the final prescription of liquid suppository. Result The best combination of the prescription were 15% of poloxamer 407,25% of poloxamer 188 and 0.4% of chitosan with the pH of 5±0.2. Conclusion The test proved to be equitable with the good intensity and bio-adhesive force of the liquid suppository.

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Pharmaceutical studies on thermos sensitive insulin anal liquid suppository

doi: 10.3969/j.issn.1006-0111.2015.05.010

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