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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(4): 324-327

JIN Qingzheng, LI Qin, ZHAO Yin. Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 324-327. doi: 10.3969/j.issn.1006-0111.2015.04.009
Citation: JIN Qingzheng, LI Qin, ZHAO Yin. Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 324-327. doi: 10.3969/j.issn.1006-0111.2015.04.009
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Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice

doi: 10.3969/j.issn.1006-0111.2015.04.009
  • 1.

    ZheJiang Quhua Hospital, Quzhou 324004, China

  • 2.

    Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China

  • Received Date: 2014-09-14
  • Rev Recd Date: 2015-03-26
  • Objective To study the hypoglycemic activity of semen Trichosanthis oil(STO) and the mechanism on diabetic mice. Methods The alloxan-induced diabetic mice were divided into different groups and given different dose of STO by gavage for 4 weeks, the changes of body weight and fasting blood glucose were investigated every week. Blood serum was drawn to determine TC, TG, NO, NOS and insulin. In addition, the effect of STO on glucose tolerance were also investigated in alloxan-induced diabetic mice. Results STO can dose dependently reduce the levels of blood glucose and increase the body weight when it was administrated orally at 5,10,20 ml·kg-1, can increase insulin and lower TC,TG,NO,NOS in blood serum, and also can improve glucose tolerance in alloxan-induced diabetic mice. Conclusion STO may potentiate the hypoglycemic effect,and can improve glucose tolerance. The hypoglycemic activity of STO may be related with increasing insulin and decreasing NO and NOS in blood serum.
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    [2] 张信岳,李 钦,陈爱君,等.活性糖元保降血糖作用实验研究[J].中国临床药理学与治疗学,2008,13(8):847-851.
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    [4] Robertson RP.Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes[J]. J Biol Chem, 2004, 279(41):2351-2354.
    [5] 王 煜,李秀钧,邬云红,等. 二甲双胍对糖脂中毒的大鼠胰岛β细胞胰岛素分泌功能的保护作用[J]. 华西医学,2009,24(4):920-922.
    [6] 黄先菊,王文英,王贵林,等. 蛇葡萄素对2型糖尿病大鼠NO/NOS水平及抗氧化能力的影响[J]. 中国现代应用药学,2008,25(2):95-98.
    [7] 王玉梅,胡燕芬,肖 怀.天然药物中降血糖成分及作用机理的研究进展[J].中国民族民间医药杂志,2008,17(7):15-17.
    [8] 卢 威,秦晓改,王跃虎,等.二氢杨梅素对四氧嘧啶性糖尿病小鼠的降糖作用研究[J].中药药理与临床,2011,27(4):15-17.
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    [11] 乐嘉静,李湛君,徐康森. 海狗油ω-3多不饱和脂肪酸对胰岛素抵抗型糖尿病大鼠的降糖作用研究[J]. 中国临床药理学与治疗学,2005,10(3):321.
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Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice

doi: 10.3969/j.issn.1006-0111.2015.04.009
  • 1. ZheJiang Quhua Hospital, Quzhou 324004, China
  • 2. Institute of Metaria Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
  • Received Date: 2014-09-14
  • Rev Recd Date: 2015-03-26

Abstract: Objective To study the hypoglycemic activity of semen Trichosanthis oil(STO) and the mechanism on diabetic mice. Methods The alloxan-induced diabetic mice were divided into different groups and given different dose of STO by gavage for 4 weeks, the changes of body weight and fasting blood glucose were investigated every week. Blood serum was drawn to determine TC, TG, NO, NOS and insulin. In addition, the effect of STO on glucose tolerance were also investigated in alloxan-induced diabetic mice. Results STO can dose dependently reduce the levels of blood glucose and increase the body weight when it was administrated orally at 5,10,20 ml·kg-1, can increase insulin and lower TC,TG,NO,NOS in blood serum, and also can improve glucose tolerance in alloxan-induced diabetic mice. Conclusion STO may potentiate the hypoglycemic effect,and can improve glucose tolerance. The hypoglycemic activity of STO may be related with increasing insulin and decreasing NO and NOS in blood serum.

JIN Qingzheng, LI Qin, ZHAO Yin. Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 324-327. doi: 10.3969/j.issn.1006-0111.2015.04.009
Citation: JIN Qingzheng, LI Qin, ZHAO Yin. Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 324-327. doi: 10.3969/j.issn.1006-0111.2015.04.009
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