Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 33 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(4): 313-315,323

ZHAO Na, Gao Feng, Liu Bin, PIAO Xianmei. Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 313-315,323. doi: 10.3969/j.issn.1006-0111.2015.04.006
Citation: ZHAO Na, Gao Feng, Liu Bin, PIAO Xianmei. Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 313-315,323. doi: 10.3969/j.issn.1006-0111.2015.04.006
shu

Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids

doi: 10.3969/j.issn.1006-0111.2015.04.006

  • Department of Pharmacology, School of Pharmacy, Harbin Medicical University, 150081 China

  • Received Date: 2014-04-09
  • Rev Recd Date: 2015-01-09
  • Objective To introduce the major pharmacological effects and research progress of benzyltetrahydroisoquinolines alkaloids. Methods The compounds structure, biological activity, mechanism and clinical applications of benzyltetrahydroisoquinolines were reviewed based on the domestic and foreign research literatures in recent years. Results Benzyltetrahydroisoquinolines alkaloids exhibit many pharmacological activities. Researches and clinic applications on anti-tumor, anti-oxidation, anti-inflammation and anti-pathogen have been developed rapidly. Conclusion Benzyltetrahydroisoquinolines alkaloids have exhibited abundant biological activities. Studying its pharmacological effects can further the understanding of its pharmacological characteristics and application prospects, and provide thoughts and enlightenment for drug development in this field.
  • [1] 吴立军,娄红祥,周 晶.天然药物化学[M].北京:人民卫生出版社,2012:382-386.
    [2] 谌 錾,丁 一,朱丽红.千金藤素的抗肿瘤作用研究进展[J]. 癌症进展,2012,10(1):31-34.
    [3] 马克龙,汪远金,周 会.千金藤碱抑制非小细胞肺癌A549细胞生长和转移以及对血红素加氧酶-1和表皮生长因子受体基因表达的影响[J].安徽中医学院学报,2013,32(2):57-63.
    [4] 吕蒙恩,肖 青,王 琳.汉防己甲素抑制PANC-1细胞增殖作用的机制探讨[J].临床血液学志,2010,23(6):327-332.
    [5] 高建莉,吕圭源,何通川.千金藤素对人结肠癌细胞HCT116裸鼠异体移植肿瘤模型肿瘤增殖的影响及机制初探[J].浙江中医药大学学报,2013,37(9):1055-1072.
    [6] 刘风玲,杨 旭.粉防己碱逆转人卵巢癌耐药细胞SKOV3/DDP耐药的逆转作用及机制[J].山东医药,2011,51(45):37-38.
    [7] 杨 旭,刘风玲.粉防己碱在逆转肿瘤化疗多药耐药性中的作用[J].现代中西医结合杂志,2011,20(15);1942-1944.
    [8] 肖 霞,陈英辉,洪 震.粉防己碱逆转多药耐药的研究进展[J].上海中医药杂志,2011,45(4):78-81.
    [9] 夏 薇,王 宁,王庆端.盐酸千金藤碱逆转MCF -7/A DR细胞多药耐药性的作用及其机制[J].重庆医学, 2011,40(1):14-19.
    [10] 陈志宝,李欣燃,朱 淼,等.白屈菜红碱抗肿瘤机制研究进展[J].江苏农业科学,2013,41(1):9-12.
    [11] 马 方,张 艳,王 宁.盐酸千金藤碱对急性脂肪肝小鼠脂代谢及过氧化的影响[J].中华中医药杂志,2011, 26(6):1429-1432.
    [12] Pinelli A, Trivulzio S, Brenna S, et al. Pretreatment with tetrandrine has protective effects against isoproterenol-induced myocardial infarction in rabbits [J]. In Vivo, 2010, 24 (3): 265-270.
    [13] 王裕勤,曹雪滨,朱元州.粉防己碱调控炎症因子减轻大鼠心肌缺血/再灌注损伤[J].中华老年多器官疾病杂志,2011,10(6):529-535.
    [14] 陈 鹏,弥 曼.左旋四氢巴马汀对局灶性脑缺血再灌注大鼠脑内核转录因子-κB细胞黏附分子-1表达的影响[J].山西医药杂志,2010,39(8):694-697.
    [15] Bae DS,Kim YH,Pan CH,et al. Protopine reduces the inflammatory activity of lipopolysaccharide-stimulatedmurine macrophages [J].BMB Rep,2012, 45(2):108-113.
    [16] 王 晓,郑立运,赵志鸿.盐酸千金藤碱抗乙型肝炎病毒的体外实验研究[J].时珍国医国药,2010,21( 12):3109-3111.
    [17] 王小玲,郁建平,范家佑.血根碱抗水霉菌体外活性研究[J].山地农业生物学报,2012,31(5):450-453.
    [18] 谢东磊,姜子涛,李 荣.荷叶碱的提取分离及其应用[J].中国食品添加剂,2011,5:201-205.
    [19] Wangchuk P, Keller PA, Pyne SG,et al.A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain[J]. J Ethnopharmacol,2013,150(3):953-959.
    [20] Margiotta A, Gray BH. Assessment of recurrent mesenteric ischemia after stenting with a pressure wire[J].Vasc Med, 2014, 19(2): 137-141.
    [21] 胡慧敏.盐酸罂粟碱对任意皮瓣微循环影响的实验研究[J].中国美容医学,2012,21(8): 1321-1323.
    [22] 李 林,刘 康, 刘保林.小檗碱改善胰岛素抵抗机制的研究进展[J].时珍国医国药,2010,21(9):2335-2336.
    [23] 张 红,王开富,谭 政.盐酸小檗碱对AchE抑制作用的实验研究[J].内科急危重症杂志, 2011, 17(2):110-111.
    [24] 刘志霞,韩淑英,李继安.人肝癌细胞胰岛素抵抗模型建立及有效中药成分的筛选[J].中国组织工程研究与临床康复, 2011,15(28):5241-5244.
    [25] 刘艳丽,郝丽莉,李笑然.羟考酮的镇痛及依赖的实验研究进展[J].中国药物滥用防治杂志,2008,14(4):221-222.
    [26] Chen CH, Liao CH, Chang YL,et al.Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines[J].Cancer Lett,2012, 315(1):1-11.
    [27] 侯 平,杨 丽,刘 宁,等.麻黄碱、β-细辛醚和去甲乌药碱对大鼠心肌细胞钙离子浓度和细胞膜钙通道的影响[J].中国医科大学学报,2013, 42(3):201-203.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3703) PDF downloads(624) Cited by()

Related
Proportional views

Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids

doi: 10.3969/j.issn.1006-0111.2015.04.006
  • Department of Pharmacology, School of Pharmacy, Harbin Medicical University, 150081 China
  • Received Date: 2014-04-09
  • Rev Recd Date: 2015-01-09

Abstract: Objective To introduce the major pharmacological effects and research progress of benzyltetrahydroisoquinolines alkaloids. Methods The compounds structure, biological activity, mechanism and clinical applications of benzyltetrahydroisoquinolines were reviewed based on the domestic and foreign research literatures in recent years. Results Benzyltetrahydroisoquinolines alkaloids exhibit many pharmacological activities. Researches and clinic applications on anti-tumor, anti-oxidation, anti-inflammation and anti-pathogen have been developed rapidly. Conclusion Benzyltetrahydroisoquinolines alkaloids have exhibited abundant biological activities. Studying its pharmacological effects can further the understanding of its pharmacological characteristics and application prospects, and provide thoughts and enlightenment for drug development in this field.

ZHAO Na, Gao Feng, Liu Bin, PIAO Xianmei. Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 313-315,323. doi: 10.3969/j.issn.1006-0111.2015.04.006
Citation: ZHAO Na, Gao Feng, Liu Bin, PIAO Xianmei. Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 313-315,323. doi: 10.3969/j.issn.1006-0111.2015.04.006
shu

    HTML

Reference (27)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return