Pharmacoeconomic evaluation of different dosing regimens of levofloxacin treating the bacterial infections of lower respiratory tract

FENG Shu

doi:10.3969/j.issn.1006-0111.2015.03.024

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Objective To evaluate the pharmacoeconomics of two different dosing regimens of levofloxacin treating the bacterial infections of lower respiratory tract, and provide the basis for selecting the security, effective and economic treatment programs clinically. Methods The 108 patients with bacterial infections of lower respiratory tract were divided into the intravenous group and sequential group randomly, the intravenous group used levofloxacin for the intravenous infusion and the sequential group firstly for the intravenous infusion and then for the oral levofloxacin capsule, and the total treatment course of two groups were 7-14 days, and the days of drug use of the two groups should be same so as to conduct the minimal cost analysis for the above two programs. Results The total cost per one patient of the intravenous group (1 779.80±304.15 yuan) was higher than the sequential group(1 290.85±173.76 yuan) significantly, treatment unit of each group needed cost 34.89 yuan and 14.52 yuan respectively. Compared with the sequential group, the intravenous group needed spend more 264.3 yuan.The recovery rate of the two groups was 72.22% and 62.96% respectively(P>0.05), the total effective rate of the two groups was 90.74% and 88.89% respectively(P>0.05), the clearance rate of bacteria of the two groups was 86.96% and 84.44% respectively(P>0.05), and the incidence of adverse reactions was 9.26% and 7.41% respectively(P>0.05). Conclusion The sequential therapy of levofloxacin was a security, effective and economic treatment program, compared with the continuous infusion, and had a more cost-effective advantages, which should be popularized from the consideration of the pharmacoeconomics level.

Pharmacoeconomic evaluation of different dosing regimens of levofloxacin treating the bacterial infections of lower respiratory tract

Department of Pharmacy, the First Chinese Medicine Hospital of Yiyang, Yiyang 413002, China

Received Date: 2014-04-30

Rev Recd Date: 2014-09-29

Key words:

Abstract: Objective To evaluate the pharmacoeconomics of two different dosing regimens of levofloxacin treating the bacterial infections of lower respiratory tract, and provide the basis for selecting the security, effective and economic treatment programs clinically. Methods The 108 patients with bacterial infections of lower respiratory tract were divided into the intravenous group and sequential group randomly, the intravenous group used levofloxacin for the intravenous infusion and the sequential group firstly for the intravenous infusion and then for the oral levofloxacin capsule, and the total treatment course of two groups were 7-14 days, and the days of drug use of the two groups should be same so as to conduct the minimal cost analysis for the above two programs. Results The total cost per one patient of the intravenous group (1 779.80±304.15 yuan) was higher than the sequential group(1 290.85±173.76 yuan) significantly, treatment unit of each group needed cost 34.89 yuan and 14.52 yuan respectively. Compared with the sequential group, the intravenous group needed spend more 264.3 yuan.The recovery rate of the two groups was 72.22% and 62.96% respectively(P>0.05), the total effective rate of the two groups was 90.74% and 88.89% respectively(P>0.05), the clearance rate of bacteria of the two groups was 86.96% and 84.44% respectively(P>0.05), and the incidence of adverse reactions was 9.26% and 7.41% respectively(P>0.05). Conclusion The sequential therapy of levofloxacin was a security, effective and economic treatment program, compared with the continuous infusion, and had a more cost-effective advantages, which should be popularized from the consideration of the pharmacoeconomics level.

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Reference (21)

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Pharmacoeconomic evaluation of different dosing regimens of levofloxacin treating the bacterial infections of lower respiratory tract

doi: 10.3969/j.issn.1006-0111.2015.03.024

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