ZHAO Xuezhu, LIU Yang, WANG Yanping, LIU Fuqiang, ZHANG Qi, LIU Dan, ZHAO Nan, HAN Dan, ZHAO Qinglan. Effect of raw material purity on the degree of substitution of hydrophobically modified Bletilla striata polysaccharide[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 221-225. doi: 10.3969/j.issn.1006-0111.2015.03.008
| Citation:
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ZHAO Xuezhu, LIU Yang, WANG Yanping, LIU Fuqiang, ZHANG Qi, LIU Dan, ZHAO Nan, HAN Dan, ZHAO Qinglan. Effect of raw material purity on the degree of substitution of hydrophobically modified Bletilla striata polysaccharide[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 221-225. doi: 10.3969/j.issn.1006-0111.2015.03.008
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Effect of raw material purity on the degree of substitution of hydrophobically modified Bletilla striata polysaccharide
- 1.
School of Pharmacy, Yanbian University, Yanji 133000, China;No. 208 Hospital of PLA, Changchun 130062, China
- 2.
Changchun Sanatorium for Retired Cadres, Shenyang Millitary Region, Changchun 130000, China
- 3.
No. 208 Hospital of PLA, Changchun 130062, China
- Received Date: 2014-12-29
- Rev Recd Date:
2015-01-20
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Abstract
Objective To improve the degree of substitution of the cholesteryl by purifying cholesteryl succinyl ester(CHS), one of the raw materials. Methods CHS was purified by recrystallization, the pure CHS structure was characterizate by differential scanning calorimetry (DSC) and X ray diffraction (XRD), the free cholesterol content of the pure and crude were determinated by high performance liquid chromatography (HPLC), the degree of substitution of the cholesteryl was determinated before and after the purified by 1H-NMR. Result CHS was purer after recrystallization, with property of crystal, which could significantly improve the degree of substitution of the cholesteryl. Conclusion The method of purification was simple and feasible, which was the basis of improving hydrophobically modified Bletilla striata polysaccharide's degree of substitution of the cholesteryl.
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