Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

XIA Shiyan; SHEN Zhuanghong; ZHANG Yingran; ZHANG Peng

doi:10.3969/j.issn.1006-0111.2015.02.022

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Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained-release capsules and citalopram tablets in the treatment of post-stroke depression. Methods 60 patients were randomly divided into venlafaxine group (n=30)and citalomram group(n=30) for 8 weeks treatment. Hamilton rating scale for depression(HAMD) and treatment emergent system scale (TESS) were used to evaluate the efficacy and side effects, respectively. Results After 4-8 weeks of treatment,both scores of HAMD of the two groups decreased significantly(P<0.05),but there was no difference between the two groups(P>0.05). The total scores of HAMD in venlafaxine group were notably lower than citalopram group after 2 weeks(P<0.05). There was no significant difference in side effects between the two groups(P>0.05). Conclusion There was no significant difference in gross curative effect and side effects between two groups; venlafaxine worked faster compared to citalopram.

Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

1. Xiaoshan Mental Health Centre, Xiaoshan Hospital, Hangzhou 311200, China

2. Xiaoshan Hospital of Chinese Traditional Medicine, Hangzhou 311200, China

Received Date: 2013-11-14

Rev Recd Date: 2014-03-31

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Abstract: Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained-release capsules and citalopram tablets in the treatment of post-stroke depression. Methods 60 patients were randomly divided into venlafaxine group (n=30)and citalomram group(n=30) for 8 weeks treatment. Hamilton rating scale for depression(HAMD) and treatment emergent system scale (TESS) were used to evaluate the efficacy and side effects, respectively. Results After 4-8 weeks of treatment,both scores of HAMD of the two groups decreased significantly(P<0.05),but there was no difference between the two groups(P>0.05). The total scores of HAMD in venlafaxine group were notably lower than citalopram group after 2 weeks(P<0.05). There was no significant difference in side effects between the two groups(P>0.05). Conclusion There was no significant difference in gross curative effect and side effects between two groups; venlafaxine worked faster compared to citalopram.

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Reference (10)

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Comparative study of venlafaxine sustained-release capsules and citalopram tablet in the treatment of post-stroke depression

doi: 10.3969/j.issn.1006-0111.2015.02.022

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