LI Dongdong, WU Yuelin, MIAO Zhenyuan, ZHANG Wannian, HUA Wansen, ZHANG Huojun. Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 125-126,178. doi: 10.3969/j.issn.1006-0111.2015.02.008
| Citation:
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LI Dongdong, WU Yuelin, MIAO Zhenyuan, ZHANG Wannian, HUA Wansen, ZHANG Huojun. Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 125-126,178. doi: 10.3969/j.issn.1006-0111.2015.02.008
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Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan
- 1.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China
- 2.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 3.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 4.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China
- 5.
Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China
- Received Date: 2014-05-01
- Rev Recd Date:
2014-08-25
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Abstract
Objective To study the hemostasis activity of iodine complex with carboxymethyl chitosan. Methods The polymers were prepared with azodiisobutyronitrile as the initiating agent and sodium acrylate, N-vinylpyrrolidone, carboxymethyl chitosan and N,N'-methylene diacrylamide as the raw materials. It was then complexed with iodine to generate iodine complex with carboxymethyl chitosan, and the hemostasis activity was tested at the same time. Results The polymers could absorb water with the value of 103g/g and showed potent hemostasis activity for auricular veins and femoral veins. Conclusion The results showed that hemostatic effect of polymers was better than that of hemostatic sponge and Quikclot.
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