ZHANG Guangjun, LIN Ling, CHEN Lina, GAO Baoan, CHEN Jianming. Stability comparison between a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel and docetaxel injection saline dilutions[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 119-121,175. doi: 10.3969/j.issn.1006-0111.2015.02.006
| Citation:
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ZHANG Guangjun, LIN Ling, CHEN Lina, GAO Baoan, CHEN Jianming. Stability comparison between a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel and docetaxel injection saline dilutions[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 119-121,175. doi: 10.3969/j.issn.1006-0111.2015.02.006
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Stability comparison between a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel and docetaxel injection saline dilutions
- 1.
Department of Pharmaceutics, Second Military Medical University, Shanghai 20043, China
- 2.
Tasly pharmaceutical Co., Ltd, Huai'an 223002, China
- 3.
Department of Pharmaceutics, Second Military Medical University, Shanghai 20043, China;Tasly pharmaceutical Co., Ltd, Huai'an 223002, China
- Received Date: 2013-11-26
- Rev Recd Date:
2014-03-16
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Abstract
Objective To establish HPLC method to detect docetaxel and compare the stability of a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel with docetaxel injection saline dilutions. Methods HPLC method was established to detect docetaxel concentration. The stability of a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel and docetaxel saline dilutions were investigated by drug concentration pH value and particle size using membranes filtration method. Results The linear range of docetaxel was 1256 μg/ml, regression equation was Y = 21.199 X + 20.488, r = 0.999 9. The drug concentration pH value and particle size of polyethylene glycol mediated lipid nanoemulsion of docetaxel was stable at room temperature in 24 hours. However the docetaxel injection saline dilutions was discovered drug precipitation in about two hours after preparation and the drug concentration was significant decreased in the filtration of docetaxel injection saline dilutions. Conclusion The novel polyethylene glycol mediated lipid nanoemulsion of docetaxel was a new stable docetaxel formulation and significantly increased the safety in clinical.
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