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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(1): 55-57

CHANG Mingquan, CHEN Lin, HE Xiuli, CHEN Fang. Determination of dexamethasone acetate in Kelaweiding liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 55-57. doi: 10.3969/j.issn.1006-0111.2015.01.014
Citation: CHANG Mingquan, CHEN Lin, HE Xiuli, CHEN Fang. Determination of dexamethasone acetate in Kelaweiding liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 55-57. doi: 10.3969/j.issn.1006-0111.2015.01.014
shu

Determination of dexamethasone acetate in Kelaweiding liniment by HPLC

doi: 10.3969/j.issn.1006-0111.2015.01.014

  • Taihe Hospital Affiliated to Hubei Medical College, Shiyan 442000, China

  • Received Date: 2014-01-24
  • Rev Recd Date: 2014-05-23
  • Objective To establish the quantitative determination method of dexamethasone acetate in Kelaweiding liniment by HPLC. Methods Column:Diamonsil-C18(150 mm×4.6 mm,5 μm),mobile phase:methanol-water-glacialaceticacid (80:20:0.5),flow rate:1.0 ml/min,UV detection wavelength:240 nm,injection volume :20 μl,column temperature:30℃. Results The standard curve was linear within the range of 2.00-64.00 μg/ml,linear equation was Y=0.405 2X+0.804 2(r=0.999 9).The average recovery was 99.3% with RSD 0.93% (n=9). Conclusion This method was simple,stable and could be used to assay dexamethasone acetate in Kelaweiding liniment.
  • [1] 常明泉,余学英,王正军,等.维地西林涂剂的制备与质量控制[J].儿科药学杂志,2012,18(11):40-42.
    [2] 韩秀梅.HPLC法测定复合维生素B片中维生素B1、B2、B6的含量[J].中国药事,2012,26(8):891-894.
    [3] 国家药典委员会.中华人民共和国药典2010年版二部[S].北京:中国医药科技出版社,2010:316.
    [4] 湖北省食品药品监督管理局.湖北省医疗机构制剂质量汇编(上册)[Z].2009:295-296.
    [5] 国家药典委员会.中华人民共和国药典2010年版二部[S].北京:中国医药科技出版社,2010:1120-1121.
    [6] 陈 红,朱 蓉.复方地塞米松夫西地酸乳膏含量测定[J].中国抗生素杂志,2012,37(12):924-924.
    [7] 黄 波,姜武民,吉祥波.复方醋酸地塞米松乳膏含量测定方法的改进[J].实用药物与临床,2011,14(4):311-312.
    [8] 陈 芳,常明泉,杜士明,等.不同浓度蒽酮-硫酸试液对白及溶胶含量的影响[J].中国药师,2012,15(11):1604-1605.
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Determination of dexamethasone acetate in Kelaweiding liniment by HPLC

doi: 10.3969/j.issn.1006-0111.2015.01.014
  • Taihe Hospital Affiliated to Hubei Medical College, Shiyan 442000, China
  • Received Date: 2014-01-24
  • Rev Recd Date: 2014-05-23

Abstract: Objective To establish the quantitative determination method of dexamethasone acetate in Kelaweiding liniment by HPLC. Methods Column:Diamonsil-C18(150 mm×4.6 mm,5 μm),mobile phase:methanol-water-glacialaceticacid (80:20:0.5),flow rate:1.0 ml/min,UV detection wavelength:240 nm,injection volume :20 μl,column temperature:30℃. Results The standard curve was linear within the range of 2.00-64.00 μg/ml,linear equation was Y=0.405 2X+0.804 2(r=0.999 9).The average recovery was 99.3% with RSD 0.93% (n=9). Conclusion This method was simple,stable and could be used to assay dexamethasone acetate in Kelaweiding liniment.

CHANG Mingquan, CHEN Lin, HE Xiuli, CHEN Fang. Determination of dexamethasone acetate in Kelaweiding liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 55-57. doi: 10.3969/j.issn.1006-0111.2015.01.014
Citation: CHANG Mingquan, CHEN Lin, HE Xiuli, CHEN Fang. Determination of dexamethasone acetate in Kelaweiding liniment by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 55-57. doi: 10.3969/j.issn.1006-0111.2015.01.014
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