Progress on anti-inflammatory natural products

HOU Xiaoli; SUN Mingxue; GAO Huanhuan; XIAO Kai

doi:10.3969/j.issn.1006-0111.2015.01.006

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Volume 33 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2015 > 33(1): 20-27

HOU Xiaoli, SUN Mingxue, GAO Huanhuan, XIAO Kai. Progress on anti-inflammatory natural products[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 20-27. doi: 10.3969/j.issn.1006-0111.2015.01.006

Citation:

HOU Xiaoli, SUN Mingxue, GAO Huanhuan, XIAO Kai. Progress on anti-inflammatory natural products[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 20-27. doi: 10.3969/j.issn.1006-0111.2015.01.006

Progress on anti-inflammatory natural products

doi: 10.3969/j.issn.1006-0111.2015.01.006

Lab of Toxicology and Pharmacology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-03-21
Rev Recd Date: 2013-07-05

Abstract

Inflammation is the defense response of the living tissues possessing vascular system to stimulations of various injury factors,which plays a vital role in the initiation and progression of many major diseases.Drugs used to treat inflammation in the clinical mainly include non-steroidal anti-inflammatory drugs (NSAIDs),steroidal anti-inflammatory drugs (SAIDs) and traditional Chinese medicine.As synthetic anti-inflammatory drugs used in clinical currently have obvious adverse reactions,more and more attention were paid to seek anti-inflammatory drugs from natural medicines.Reviews reported before mainly focus on anti-inflammation mechanism of natural medicine,however,there are few reports on the summary of anti-inflammatory natural products.Active natural products which were reported to possess anti-inflammatory effects in recent years were summarized in order to provide information for further study of anti-inflammatory drugs research.
- natural products,
- anti-inflammatory activities,
- immunity

References

[1]	Ferrero-Miliani L,Nielsen O,Andersen P,et al.Chronic inflammation:importance of NOD2 and NALP3 in interleukin-1β generation[J].Clin Exp Immuno,2007,147(2):227-235.
[2]	姜代勋,陈武,陈益山,等.抗炎中药作用机制新靶点研究——对cAMP-磷酸二酯酶活性的影响[J].中兽医医药杂志,2009,28(1):35-37.
[3]	倪健,董竞成.三种中药药效成分抗支气管哮喘变应性炎症的实验研究[J].中国实验方剂学杂志,2004,10(4):49-51.
[4]	朱江,蔡德海,芮菁.栀子的抗炎镇痛作用研究[J].中草药,2000,31(3):198-200.
[5]	Choi J,Lee KT,Choi MY,et al.Antinociceptive anti-inflammatory effect of monotropein isolated from the root of Morinda officinalis[J].Biol Pharm Bull,2005,28(10):1915-1918.
[6]	王晓玉,魏伟,唐丽琴,等.芍药苷对佐剂性关节炎大鼠腹腔巨噬细胞吞噬功能及其产生细胞因子的影响[J].安徽医科大学学报,2007,42(2):189-192.
[7]	邓文龙,刘家玉,聂仁吉.脱水穿心莲内酯琥珀酸半酯的药理作用研究Ⅰ.抗炎作用[J].药学学报,1980,15(10):590-597.
[8]	张明发,沈雅琴,朱自平,等.辛温 (热) 合归脾胃经中药药性研究IV.镇痛作用[J].中药药理与临床,1996,12(4):1-4.
[9]	吴晓松,李晓光,肖飞,等.砂仁挥发油中乙酸龙脑酯镇痛抗炎作用的研究[J].中药材,2004,27(6):438-439.
[10]	Jin HZ,Hwang BY,Kim HS,et al.Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production[J].J Nat Prod,2002,65(1):89-91.
[11]	Dufour D,Pichette A,Mshvildadze V,et al.Antioxidant,anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius[J].J Ethnopharmacol,2007,111(1):22-28.
[12]	黄能慧,李诚秀.甘草酸铵的抗炎作用[J].贵阳医学院学报,1995,20(1):26-28.
[13]	Rhule A,Navarro S,Smith JR,et al.Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW 264.7 cells[J].J Ethnophamacol,2006,106(1):121-128.
[14]	Wang C,Schuller Levis GB,Lee EB,et al.Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells[J].Int Immunopharmacol,2004,4(8):1039-1049.
[15]	黄丰,邓华明,朱苗苗,等.阿魏酸对脂多糖诱导的小鼠小胶质细胞炎性反应的抑制作用[J].动物学研究,2011,32(3):311-316.
[16]	Ding M,Ye TX,Zhao GR, et al.Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-α[J].Int Immunopharmacol,2005,5(11):1641-1651.
[17]	Ban HS,Lim SS,Suzuki K,et al.Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production[J].Planta Med,2003,69(5):408-412.
[18]	董培智,朴晋华,高天鉷,等.祖师麻注射液的抗炎作用研究[J].山西医科大学学报,1999,30(S1):5l-53.
[19]	王文俊,姚智.大黄素,丹参素对单核细胞分泌炎性细胞因子的调节[J].中国免疫学杂志,1995,11(6):370-372.
[20]	秦爱萍,张传印,陆丽.左旋紫草素抗炎作用的实验研究[J].现代生物医学进展,2009,9(18):3432-3434.
[21]	胡明亮,樊均明.鱼腥草与肾脏[J].国外医学:泌尿系统分册,2003,23(2):208-210.
[22]	薛宝云,李文,李丽,等.防风色原酮甙类成分的药理活性研究[J].中国实验方剂学杂志,2001,S1:287-290.
[23]	Garg A,Garg S,Zaneveld L,et al.Chemistry and pharmacology of the citrus bioflavonoid hesperidin[J].Phytother Res,2001,15(8):655-669.
[24]	唐宁,李子艳,周咏梅,等.木樨草素抗炎作用机制的初步探讨[J].中国临床药理学与治疗学,2007,12(2):195-199.
[25]	臧宝霞,司南.羟基红花黄色素 A 对血小板活化因子的拮抗作用[J].药学学报,2002,37(9):696-699.
[26]	刘芬,刘洁,陈霞,等.氧化苦参碱的抗炎作用及其机制[J].吉林大学学报:医学版,2006,31(5):728-730.
[27]	范治云,罗红,刘玉兰,等.川芎嗪的抗炎作用与组胺、5-羟色胺的关系[J].中药新药与临床药理,2004,15(2):93-94.
[28]	李晓娟,王培训,刘良,等.青藤碱抗炎抗风湿作用机理研究[J].广州中医药大学学报,2004,21(1):34-36.
[29]	张乐之,何华美,李新芳,等.粉防己碱的抗炎作用与炎症白细胞 cAMP 的关系[J].中国药理学通报,2003,19(7):791-796.
[30]	Choi B, Ahn I,Kim Y,et al.Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte[J].Exp Mol Med,2006,38(6):599-605.
[31]	Taguchi K,Hagiwara Y,Kajiyama K,et al.Pharmacological studies of Houttuyniae herba:the anti-inflammatory effect of quercitrin[J].Yakugaku Zasshi,1993,113(4):327-333.
[32]	刘琳娜,程建峰.乙醇提取新鲜当归油的抗炎镇痛作用[J].中国药房,2002,13(9):526-527.
[33]	Kobayashi Y,Shen J,Li S,et al.Suppressive effects of a plant-origin polyol,dulcitol on collagen-induced arthritis in mice[J].Nihon Yakurigaku Zasshi,1997,110(Supple 1):132-137.
[34]	阮金兰,邹健,蔡亚玲.菝葜的抗炎活性成分研究[J].医药导报,2005,24(8):670-672.

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通讯作者: 陈斌, bchen63@163.com

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Progress on anti-inflammatory natural products

Lab of Toxicology and Pharmacology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-03-21

Rev Recd Date: 2013-07-05

Key words:

Abstract: Inflammation is the defense response of the living tissues possessing vascular system to stimulations of various injury factors,which plays a vital role in the initiation and progression of many major diseases.Drugs used to treat inflammation in the clinical mainly include non-steroidal anti-inflammatory drugs (NSAIDs),steroidal anti-inflammatory drugs (SAIDs) and traditional Chinese medicine.As synthetic anti-inflammatory drugs used in clinical currently have obvious adverse reactions,more and more attention were paid to seek anti-inflammatory drugs from natural medicines.Reviews reported before mainly focus on anti-inflammation mechanism of natural medicine,however,there are few reports on the summary of anti-inflammatory natural products.Active natural products which were reported to possess anti-inflammatory effects in recent years were summarized in order to provide information for further study of anti-inflammatory drugs research.

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Reference (34)

[1]	Ferrero-Miliani L,Nielsen O,Andersen P,et al.Chronic inflammation:importance of NOD2 and NALP3 in interleukin-1β generation[J].Clin Exp Immuno,2007,147(2):227-235.
[2]	姜代勋,陈武,陈益山,等.抗炎中药作用机制新靶点研究——对cAMP-磷酸二酯酶活性的影响[J].中兽医医药杂志,2009,28(1):35-37.
[3]	倪健,董竞成.三种中药药效成分抗支气管哮喘变应性炎症的实验研究[J].中国实验方剂学杂志,2004,10(4):49-51.
[4]	朱江,蔡德海,芮菁.栀子的抗炎镇痛作用研究[J].中草药,2000,31(3):198-200.
[5]	Choi J,Lee KT,Choi MY,et al.Antinociceptive anti-inflammatory effect of monotropein isolated from the root of Morinda officinalis[J].Biol Pharm Bull,2005,28(10):1915-1918.
[6]	王晓玉,魏伟,唐丽琴,等.芍药苷对佐剂性关节炎大鼠腹腔巨噬细胞吞噬功能及其产生细胞因子的影响[J].安徽医科大学学报,2007,42(2):189-192.
[7]	邓文龙,刘家玉,聂仁吉.脱水穿心莲内酯琥珀酸半酯的药理作用研究Ⅰ.抗炎作用[J].药学学报,1980,15(10):590-597.
[8]	张明发,沈雅琴,朱自平,等.辛温 (热) 合归脾胃经中药药性研究IV.镇痛作用[J].中药药理与临床,1996,12(4):1-4.
[9]	吴晓松,李晓光,肖飞,等.砂仁挥发油中乙酸龙脑酯镇痛抗炎作用的研究[J].中药材,2004,27(6):438-439.
[10]	Jin HZ,Hwang BY,Kim HS,et al.Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production[J].J Nat Prod,2002,65(1):89-91.
[11]	Dufour D,Pichette A,Mshvildadze V,et al.Antioxidant,anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius[J].J Ethnopharmacol,2007,111(1):22-28.
[12]	黄能慧,李诚秀.甘草酸铵的抗炎作用[J].贵阳医学院学报,1995,20(1):26-28.
[13]	Rhule A,Navarro S,Smith JR,et al.Panax notoginseng attenuates LPS-induced pro-inflammatory mediators in RAW 264.7 cells[J].J Ethnophamacol,2006,106(1):121-128.
[14]	Wang C,Schuller Levis GB,Lee EB,et al.Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells[J].Int Immunopharmacol,2004,4(8):1039-1049.
[15]	黄丰,邓华明,朱苗苗,等.阿魏酸对脂多糖诱导的小鼠小胶质细胞炎性反应的抑制作用[J].动物学研究,2011,32(3):311-316.
[16]	Ding M,Ye TX,Zhao GR, et al.Aqueous extract of Salvia miltiorrhiza attenuates increased endothelial permeability induced by tumor necrosis factor-α[J].Int Immunopharmacol,2005,5(11):1641-1651.
[17]	Ban HS,Lim SS,Suzuki K,et al.Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production[J].Planta Med,2003,69(5):408-412.
[18]	董培智,朴晋华,高天鉷,等.祖师麻注射液的抗炎作用研究[J].山西医科大学学报,1999,30(S1):5l-53.
[19]	王文俊,姚智.大黄素,丹参素对单核细胞分泌炎性细胞因子的调节[J].中国免疫学杂志,1995,11(6):370-372.
[20]	秦爱萍,张传印,陆丽.左旋紫草素抗炎作用的实验研究[J].现代生物医学进展,2009,9(18):3432-3434.
[21]	胡明亮,樊均明.鱼腥草与肾脏[J].国外医学:泌尿系统分册,2003,23(2):208-210.
[22]	薛宝云,李文,李丽,等.防风色原酮甙类成分的药理活性研究[J].中国实验方剂学杂志,2001,S1:287-290.
[23]	Garg A,Garg S,Zaneveld L,et al.Chemistry and pharmacology of the citrus bioflavonoid hesperidin[J].Phytother Res,2001,15(8):655-669.
[24]	唐宁,李子艳,周咏梅,等.木樨草素抗炎作用机制的初步探讨[J].中国临床药理学与治疗学,2007,12(2):195-199.
[25]	臧宝霞,司南.羟基红花黄色素 A 对血小板活化因子的拮抗作用[J].药学学报,2002,37(9):696-699.
[26]	刘芬,刘洁,陈霞,等.氧化苦参碱的抗炎作用及其机制[J].吉林大学学报:医学版,2006,31(5):728-730.
[27]	范治云,罗红,刘玉兰,等.川芎嗪的抗炎作用与组胺、5-羟色胺的关系[J].中药新药与临床药理,2004,15(2):93-94.
[28]	李晓娟,王培训,刘良,等.青藤碱抗炎抗风湿作用机理研究[J].广州中医药大学学报,2004,21(1):34-36.
[29]	张乐之,何华美,李新芳,等.粉防己碱的抗炎作用与炎症白细胞 cAMP 的关系[J].中国药理学通报,2003,19(7):791-796.
[30]	Choi B, Ahn I,Kim Y,et al.Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte[J].Exp Mol Med,2006,38(6):599-605.
[31]	Taguchi K,Hagiwara Y,Kajiyama K,et al.Pharmacological studies of Houttuyniae herba:the anti-inflammatory effect of quercitrin[J].Yakugaku Zasshi,1993,113(4):327-333.
[32]	刘琳娜,程建峰.乙醇提取新鲜当归油的抗炎镇痛作用[J].中国药房,2002,13(9):526-527.
[33]	Kobayashi Y,Shen J,Li S,et al.Suppressive effects of a plant-origin polyol,dulcitol on collagen-induced arthritis in mice[J].Nihon Yakurigaku Zasshi,1997,110(Supple 1):132-137.
[34]	阮金兰,邹健,蔡亚玲.菝葜的抗炎活性成分研究[J].医药导报,2005,24(8):670-672.

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Progress on anti-inflammatory natural products

doi: 10.3969/j.issn.1006-0111.2015.01.006

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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