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Volume 32 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(5): 360-361,388

HAO Shaojun, LV Hongdi, LI Jun, SU Feng, ZHANG Zhengchen. Effect of Xinnaoning tablet on blood stasis model in rats[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 360-361,388. doi: 10.3969/j.issn.1006-0111.2014.05.012
Citation: HAO Shaojun, LV Hongdi, LI Jun, SU Feng, ZHANG Zhengchen. Effect of Xinnaoning tablet on blood stasis model in rats[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 360-361,388. doi: 10.3969/j.issn.1006-0111.2014.05.012
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Effect of Xinnaoning tablet on blood stasis model in rats

doi: 10.3969/j.issn.1006-0111.2014.05.012

  • No. 371 Central Hospital of PLA, Xinxiang 453000, China

  • Received Date: 2012-08-20
  • Rev Recd Date: 2013-08-30
  • Objective To study the effect of Xinnaoning tablets on blood stasis rat model which was caused to dexamethasone sodium phosphate injection with symptom score, K-value of blood, modified index, electrophoresis index. Methods 60 rats, were divided into 6 groups stochastically, and 1 group for vacuity contrast group, the other 5 groups for blood stasis model, the 5 groups were model group, Naoan tablets group, high dose, medium dose and low dose Xinnaoning tablets groups. Symptom score were evaluated, K-value of blood, Modified index, Electrophoresis index were measured. Results The Model was constructed successfully, model group and administrate groups had significant blood symptoms (P<0.01).The effect of high dose Xinnaoning tablets group to blood stasis rat model which was caused to dexamethasone sodium phosphate injection was best. High dose and medium dose Xinnaoning tablets groups could induce K-value significantly (P<0.01). Xinnaoning tablets groups could improve modified index and electrophoresis index significantly (P<0.01), and the effect of high dose and medium dose Xinnaoning tablets groups to blood stasis rat model which was caused to dexamethasone sodium phosphate injection were better. Conclusion Xinnaoning tablets had good improvement effect on blood stasis.
  • [1] 苗明三,陈元朋,吴巍.姜黄素对大鼠血瘀性脑缺血模型血液流变学及脑匀浆LD、LDH和TchE水平的影响[J].中药药理与临床,2010,26(1):29-31.
    [2] 田金洲,王永炎,徐意,等. 血瘀证动物模型的种类、评价与研究[J].北京中医药大学学报, 2006,29(6):396-400.
    [3] 李仪奎.中药药理实验方法学[M].上海:上海科技出版社,2006.
    [4] 董文心,阮克锋,顾丰华,等.归苓片改善动物学习记忆功能的研究[J].中草药,2006,37(12):1831-1835.
    [5] 鲍蕾蕾,陈海飞,卞俊,等.健步关节胶囊对家兔骨关节病模型相关因子的影响[J].药学实践杂志,2012,30(3):211-212.
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Effect of Xinnaoning tablet on blood stasis model in rats

doi: 10.3969/j.issn.1006-0111.2014.05.012
  • No. 371 Central Hospital of PLA, Xinxiang 453000, China
  • Received Date: 2012-08-20
  • Rev Recd Date: 2013-08-30

Abstract: Objective To study the effect of Xinnaoning tablets on blood stasis rat model which was caused to dexamethasone sodium phosphate injection with symptom score, K-value of blood, modified index, electrophoresis index. Methods 60 rats, were divided into 6 groups stochastically, and 1 group for vacuity contrast group, the other 5 groups for blood stasis model, the 5 groups were model group, Naoan tablets group, high dose, medium dose and low dose Xinnaoning tablets groups. Symptom score were evaluated, K-value of blood, Modified index, Electrophoresis index were measured. Results The Model was constructed successfully, model group and administrate groups had significant blood symptoms (P<0.01).The effect of high dose Xinnaoning tablets group to blood stasis rat model which was caused to dexamethasone sodium phosphate injection was best. High dose and medium dose Xinnaoning tablets groups could induce K-value significantly (P<0.01). Xinnaoning tablets groups could improve modified index and electrophoresis index significantly (P<0.01), and the effect of high dose and medium dose Xinnaoning tablets groups to blood stasis rat model which was caused to dexamethasone sodium phosphate injection were better. Conclusion Xinnaoning tablets had good improvement effect on blood stasis.

HAO Shaojun, LV Hongdi, LI Jun, SU Feng, ZHANG Zhengchen. Effect of Xinnaoning tablet on blood stasis model in rats[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 360-361,388. doi: 10.3969/j.issn.1006-0111.2014.05.012
Citation: HAO Shaojun, LV Hongdi, LI Jun, SU Feng, ZHANG Zhengchen. Effect of Xinnaoning tablet on blood stasis model in rats[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 360-361,388. doi: 10.3969/j.issn.1006-0111.2014.05.012
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