Stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection

FANG Baoxia; CHEN Fuchao; LI Chunlei; LIU Huimin; ZHU Xuesong

doi:10.3969/j.issn.1006-0111.2014.05.008

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hours at ambient temperature were observed. The concentrations of the two drugs were determined by HPLC. The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min.. Results No significant differences were found in the pH value and appearance of the solution. The contents of tramadol hydrochloride and fentanyl citrate were high than 98% within 72 hours. Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection was stability within 72 hours under room temperature.

Stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection

Department of Pharmacy, Dongfeng Hospital Affiliated to Hubei University of Medicine, Shiyan 442008, China

Received Date: 2013-01-19

Rev Recd Date: 2013-04-10

Key words:

Abstract: Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hours at ambient temperature were observed. The concentrations of the two drugs were determined by HPLC. The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min.. Results No significant differences were found in the pH value and appearance of the solution. The contents of tramadol hydrochloride and fentanyl citrate were high than 98% within 72 hours. Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection was stability within 72 hours under room temperature.

HTML

Reference (11)

[1]	张哲峰,詹华,梁兰萍.新型镇痛药物盐酸曲马多的研究进展[J]. 中国药师, 1999,2(6):290-291.
[2]	宋先荣,艾艳秋. 术后镇痛研究的进展[J]. 医学综述, 2009, 15(5):778-781.
[3]	高星杨,刘卫珍,王明德. 病人自控镇痛(PCA)的临床应用进展[J]. 中国麻醉与镇痛, 2007,9(1):67-71.
[4]	李双凤.王亚平,王丹,等.布托啡诺或曲马多复合芬太尼用于全麻术后镇痛的临床效果比较[J]. 中国现代手术学杂志,2011,15(2):148-152.
[5]	吐尔孙·依敏.曲马多及芬太尼联合用于上腹部术后静脉镇痛的临床观察[J]. 中国社区医生,2012,14(11):29.
[6]	陈立众.曲马多复合芬太尼与芬太尼全麻术后静脉镇痛比较[J]. 江西医药,2010,45 (6):584-586.
[7]	陈业松.曲马多及芬太尼联合用于上腹部术后静脉镇痛的观察[J]. 中国医药导报,2009,6 (22):106-107.
[8]	林春发.曲马多与芬太尼联合用于剖宫产术后镇痛的观察[J]. 海峡药学, 2009, 21(8):107-108.
[9]	徐帆.注射剂配伍稳定性研究方法学分析与评价[J]. 中国医院药学杂志, 2009,26(10):1136-1137.
[10]	于淑俊,汤新强.静脉给药体外配伍稳定性的研究进展[J]. 大连医科大学学报,2010, 32(5):596-599.
[11]	陈富超,方宝霞,丁洁,等. 高效液相色谱法同时测定静脉镇痛液中盐酸吗啡和盐酸曲马多及柠檬酸芬太尼与氯诺昔康的含量[J]. 中国医药, 2011, 6(8):960-961.

Message Board

Stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection

doi: 10.3969/j.issn.1006-0111.2014.05.008

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views