Progress on solid self-microemulsifying drug delivery system for oral administration

ZHAO Jiali; WEN Xu; ZHANG Jing; LIU Jianqing; SONG Hongtao

doi:10.3969/j.issn.1006-0111.2014.04.005

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Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS). Methods Relevant literatures at home and abroad in recent years were consulted and summarized. Results Solid self-microemulsions carrier, solidification technology and controlled release formulations were discussed, in order to provide relevant references for improving the bioavailability of water-insoluble drugs and the SMEDDS technology for drug release characteristics. Conclusion The utilization of the solid self-emulsifying drug delivery system could significantly enhance the oral bioavailability of water-insoluble drugs.As a new formulation, S-SMEDDS presented huge potential.

Progress on solid self-microemulsifying drug delivery system for oral administration

1. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Medicine, Xiamen University, Xiamen 360005, China

2. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Pharmacy, Fujian Medical University, Fuzhou 350108, China

3. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

Received Date: 2013-02-26

Rev Recd Date: 2013-09-02

Key words:

Abstract: Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS). Methods Relevant literatures at home and abroad in recent years were consulted and summarized. Results Solid self-microemulsions carrier, solidification technology and controlled release formulations were discussed, in order to provide relevant references for improving the bioavailability of water-insoluble drugs and the SMEDDS technology for drug release characteristics. Conclusion The utilization of the solid self-emulsifying drug delivery system could significantly enhance the oral bioavailability of water-insoluble drugs.As a new formulation, S-SMEDDS presented huge potential.

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Progress on solid self-microemulsifying drug delivery system for oral administration

doi: 10.3969/j.issn.1006-0111.2014.04.005

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