Signaling pathway of acetylcholine receptors in atherosclerosis induced by nicotinic

LIU Dianhua; ZHANG Enhui; LIU Chong; FAN Boshi; CAI Guojun

doi:10.3969/j.issn.1006-0111.2014.02.001

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Objective Atherosclerosis is an inflammatory disease in the vessel wall. Nicotine, a major component of cigarette smoke, is an independent risk factor for cardiovascular diseases including atherosclerosis. Recent studies have shown that nicotine (the addictive component of cigarettes) binds to high affinity cell-surface receptors and accelerates the atherogenic process. These receptors were called nicotinic acetylcholine receptors (nAChR) and expressed ubiquitously in almost all cells existing in the blood vessels. Therefore, the pro-atherogenic effects of nAChR pathway ligands were summarized which would enhance the understanding of the role of nicotine and nAChR in the pathophysiology of atherosclerosis. The signaling pathways underlying nAChR subunits in cells were described that play an important role in atherosclerosis, i.e. VSMCs, endothelial cells, platelets and immune cells. How these pathways converge on the growth and survival of atheromatous plaques were also discussed. Finally, the feasibility of nAChR ligands as therapeutic targets for atherosclerosis was summarized.

Signaling pathway of acetylcholine receptors in atherosclerosis induced by nicotinic

Department of Pharmacology, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-07-28

Rev Recd Date: 2013-10-14

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Abstract: Objective Atherosclerosis is an inflammatory disease in the vessel wall. Nicotine, a major component of cigarette smoke, is an independent risk factor for cardiovascular diseases including atherosclerosis. Recent studies have shown that nicotine (the addictive component of cigarettes) binds to high affinity cell-surface receptors and accelerates the atherogenic process. These receptors were called nicotinic acetylcholine receptors (nAChR) and expressed ubiquitously in almost all cells existing in the blood vessels. Therefore, the pro-atherogenic effects of nAChR pathway ligands were summarized which would enhance the understanding of the role of nicotine and nAChR in the pathophysiology of atherosclerosis. The signaling pathways underlying nAChR subunits in cells were described that play an important role in atherosclerosis, i.e. VSMCs, endothelial cells, platelets and immune cells. How these pathways converge on the growth and survival of atheromatous plaques were also discussed. Finally, the feasibility of nAChR ligands as therapeutic targets for atherosclerosis was summarized.

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Reference (20)

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Signaling pathway of acetylcholine receptors in atherosclerosis induced by nicotinic

doi: 10.3969/j.issn.1006-0111.2014.02.001

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